ID A0A0C4ZQW2_9TELE Unreviewed; 173 AA. AC A0A0C4ZQW2; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 12-AUG-2020, entry version 20. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430}; GN Name=ND6 {ECO:0000313|EMBL:AJJ48735.1}; OS Cyprinus carpio 'Furong' x Carassius auratus red var. OG Mitochondrion {ECO:0000313|EMBL:AJJ48735.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Cyprinidae intergeneric hybrids. OX NCBI_TaxID=1610701 {ECO:0000313|EMBL:AJJ48735.1}; RN [1] {ECO:0000313|EMBL:AJJ48735.1} RP NUCLEOTIDE SEQUENCE. RA Peng H.Z., Xiao T.Y.; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AJJ48735.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25648921; RA Peng H., Liu Q., Xiao T.; RT "Inheritance of the complete mitochondrial genomes Cyprinus capio RT furong(female symbol) x Cyprinus carpio var.singguonensis(male symbol)."; RL Mitochondrial DNA 1-2:0-0(2015). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|RuleBase:RU004430}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|RuleBase:RU004430}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|ARBA:ARBA00004225, ECO:0000256|RuleBase:RU004430}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004225, CC ECO:0000256|RuleBase:RU004430}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000256|RuleBase:RU004430}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP210473; AJJ48735.1; -; Genomic_DNA. DR RefSeq; YP_009122676.1; NC_026543.1. DR GeneID; 23630071; -. DR CTD; 4541; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004430}; KW Membrane {ECO:0000256|RuleBase:RU004430}; KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:AJJ48735.1}; KW NAD {ECO:0000256|RuleBase:RU004430}; KW Respiratory chain {ECO:0000256|RuleBase:RU004430}; KW Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|RuleBase:RU004430}; KW Transmembrane {ECO:0000256|RuleBase:RU004430}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004430}; KW Transport {ECO:0000256|RuleBase:RU004430}; KW Ubiquinone {ECO:0000256|RuleBase:RU004430}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..173 FT /note="NADH-ubiquinone oxidoreductase chain 6" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002182152" FT TRANSMEM 51..75 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 87..110 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 130..159 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" SQ SEQUENCE 173 AA; 18053 MW; 88E9BA5CA1EA56A2 CRC64; MTYFMFLLLM ALVVGLVAVA SNPTPYFAAL GLVVAAGVGC GVLVGHGGSF LSLVLFLIYL GGMLVVFAYS AALAAEPFPE AWGIRSVLGY VLVYLLGVGL VAGIFWGGWY EGSWVVVDGL KEFSVLRGDI SGVAVMYSSG GGILVICAWV VLLTLLVVLE LTRGLSRGAL RAV //