ID A0A0C4ZQW2_9TELE Unreviewed; 173 AA. AC A0A0C4ZQW2; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 13-FEB-2019, entry version 15. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430}; GN Name=ND6 {ECO:0000313|EMBL:AJJ48735.1}; OS Cyprinus carpio 'Furong' x Carassius auratus red var. OG Mitochondrion {ECO:0000313|EMBL:AJJ48735.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Cyprinidae hybrid sp.. OX NCBI_TaxID=1610701 {ECO:0000313|EMBL:AJJ48735.1}; RN [1] {ECO:0000313|EMBL:AJJ48735.1} RP NUCLEOTIDE SEQUENCE. RA Peng H.Z., Xiao T.Y.; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AJJ48735.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25648921; RA Peng H., Liu Q., Xiao T.; RT "Inheritance of the complete mitochondrial genomes Cyprinus capio RT furong(female symbol) x Cyprinus carpio var.singguonensis(male RT symbol)."; RL Mitochondrial DNA 1-2:0-0(2015). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU004430}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU004430}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU004430}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000256|RuleBase:RU004430, ECO:0000256|SAAS:SAAS00585382}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP210473; AJJ48735.1; -; Genomic_DNA. DR RefSeq; YP_009122676.1; NC_026543.1. DR GeneID; 23630071; -. DR CTD; 4541; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004430}; KW Membrane {ECO:0000256|RuleBase:RU004430, KW ECO:0000256|SAAS:SAAS00477717}; KW Mitochondrion {ECO:0000256|RuleBase:RU004430, KW ECO:0000313|EMBL:AJJ48735.1}; KW NAD {ECO:0000256|RuleBase:RU004430, ECO:0000256|SAAS:SAAS00119311}; KW Respiratory chain {ECO:0000256|RuleBase:RU004430}; KW Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|RuleBase:RU004430, KW ECO:0000256|SAAS:SAAS01134433}; KW Transmembrane {ECO:0000256|RuleBase:RU004430, KW ECO:0000256|SAAS:SAAS00119307}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004430, KW ECO:0000256|SAAS:SAAS00119309}; KW Transport {ECO:0000256|RuleBase:RU004430}; KW Ubiquinone {ECO:0000256|RuleBase:RU004430}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 173 NADH-ubiquinone oxidoreductase chain 6. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002182152. FT TRANSMEM 51 75 Helical. {ECO:0000256|RuleBase:RU004430}. FT TRANSMEM 87 110 Helical. {ECO:0000256|RuleBase:RU004430}. FT TRANSMEM 130 159 Helical. {ECO:0000256|RuleBase:RU004430}. SQ SEQUENCE 173 AA; 18053 MW; 88E9BA5CA1EA56A2 CRC64; MTYFMFLLLM ALVVGLVAVA SNPTPYFAAL GLVVAAGVGC GVLVGHGGSF LSLVLFLIYL GGMLVVFAYS AALAAEPFPE AWGIRSVLGY VLVYLLGVGL VAGIFWGGWY EGSWVVVDGL KEFSVLRGDI SGVAVMYSSG GGILVICAWV VLLTLLVVLE LTRGLSRGAL RAV //