ID A0A0C4VV45_9REOV Unreviewed; 483 AA. AC A0A0C4VV45; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 23-MAY-2018, entry version 5. DE RecName: Full=Non-structural protein 1 {ECO:0000256|RuleBase:RU361227}; DE Short=NSP1 {ECO:0000256|RuleBase:RU361227}; DE AltName: Full=NCVP2 {ECO:0000256|RuleBase:RU361227}; DE AltName: Full=Non-structural RNA-binding protein 53 {ECO:0000256|RuleBase:RU361227}; DE Flags: Fragment; OS Human rotavirus A. OC Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus; OC Rotavirus A. OX NCBI_TaxID=10941 {ECO:0000313|EMBL:AJA72669.1}; RN [1] {ECO:0000313|EMBL:AJA72669.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RVA/Human-wt/BRA/SE20323/2011/G3P8 RC {ECO:0000313|EMBL:AJA72669.1}; RA Gomez M.M., Costa-Carvalho F.A., da Silva M.F.M., Rose Tl., RA Leite J.P.G.; RT "Infections with group A rotavirus genotypes G3P[8] and G9P[8] in RT Brazil 2001-2011: phylogenetic analyses and epidemiological aspects."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays a role in the inhibition of host innate immunity CC by inducing the degradation of key host factors required to CC activate interferon production such as IRF3, IRF5 or IRF7. CC Associates with components of cullin RING ligases (CRLs) including CC CUL1 or CUL3, which are essential multisubunit ubiquitination CC complexes, to modulate their activities. CC {ECO:0000256|RuleBase:RU361227}. CC -!- SUBUNIT: Interacts (via C-terminus) with host IRF3; this CC interaction leads to IRF3 degradation. Interacts with host IRF7; CC this interaction leads to IRF7 degradation. CC {ECO:0000256|RuleBase:RU361227}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton CC {ECO:0000256|RuleBase:RU361227}. CC -!- DOMAIN: The integrity of the zinc-binding domain in NSP1 is CC important for degradation of host IRF3. CC {ECO:0000256|RuleBase:RU361227}. CC -!- SIMILARITY: Belongs to the rotavirus NSP1 family. CC {ECO:0000256|RuleBase:RU361227}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ454631; AJA72669.1; -; Genomic_RNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0039548; P:suppression by virus of host IRF3 activity; IEA:UniProtKB-KW. DR GO; GO:0039557; P:suppression by virus of host IRF7 activity; IEA:UniProtKB-KW. DR GO; GO:0039644; P:suppression by virus of host NF-kappaB transcription factor activity; IEA:UniProtKB-KW. DR HAMAP; MF_04088; ROTA_NSP1; 1. DR InterPro; IPR002148; Rotavirus_NSP1. DR Pfam; PF00981; Rota_NS53; 1. PE 3: Inferred from homology; KW Host cytoplasm {ECO:0000256|RuleBase:RU361227}; KW Host cytoskeleton {ECO:0000256|RuleBase:RU361227}; KW Host-virus interaction {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host IRF3 by virus {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host IRF7 by virus {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host RLR pathway by virus KW {ECO:0000256|RuleBase:RU361227}; KW Interferon antiviral system evasion {ECO:0000256|RuleBase:RU361227}; KW Metal-binding {ECO:0000256|RuleBase:RU361227}; KW RNA-binding {ECO:0000256|RuleBase:RU361227}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU361227}. FT NON_TER 1 1 {ECO:0000313|EMBL:AJA72669.1}. SQ SEQUENCE 483 AA; 57242 MW; 7E267C3688A50092 CRC64; FKDACYYYKR INKLNHAVLK LGVNDTWRPS PPTKYKGWCL DCCQHTDLTY CRGCTMYHVC QWCSQYDRCF LDNQPHLLRM RTFKNEVTKN DLFNLIDMYN ILFPINQRIV DKFISSTRQH KCRNECMTQW YNHLLMPITL QSLSIELDGD VYYVFGYYDS MRDVNQTPFS FTNLIDMYDK LLLDNVNFNR MSFLPVALQQ EYALRYFSKS RFISEKRKCI SDLHFSTNVI ENLHNPSFKI QITRNCSELS SDWNGACKLI KDMNNYFNVL KTSHIEFYSI STRCRMFTQY KLKIASKHIK PNYVTSNHRT SATEVHNCKW CSINNGYTVW NDFRIKKIYD NIFNFLRALV KSNSNIGHCS SQEKIYEHVK NVLDVCNDEK WKMAVAEIFN CLEPVELDTA KYVLFNHEVN WDVINLLVQS VGKVPQILTL NDIIIIMKSI IYEWFDIRYM RNTPMTTFTV DKLRQLCTGV KTIVYDSGIS DIE //