ID A0A0C4VV45_9REOV Unreviewed; 483 AA. AC A0A0C4VV45; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 22-JUL-2015, entry version 3. DE RecName: Full=Non-structural protein 1 {ECO:0000256|RuleBase:RU361227}; DE Short=NSP1 {ECO:0000256|RuleBase:RU361227}; DE AltName: Full=NCVP2 {ECO:0000256|RuleBase:RU361227}; DE AltName: Full=Non-structural RNA-binding protein 53 {ECO:0000256|RuleBase:RU361227}; DE Flags: Fragment; OS Human rotavirus A. OC Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus; OC Rotavirus A. OX NCBI_TaxID=10941 {ECO:0000313|EMBL:AJA72669.1}; RN [1] {ECO:0000313|EMBL:AJA72669.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RVA/Human-wt/BRA/SE20323/2011/G3P8 RC {ECO:0000313|EMBL:AJA72669.1}; RA Gomez M.M., Costa-Carvalho F.A., da Silva M.F.M., Rose Tl., RA Leite J.P.G.; RT "Infections with group A rotavirus genotypes G3P[8] and G9P[8] in RT Brazil 2001-2011: phylogenetic analyses and epidemiological aspects."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Seems to induce the proteasome-dependent degradation of CC IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon CC response and establishment of the antiviral state. Binds and CC targets IRF3 early post-infection and suppresses IRF3 nuclear CC translocation. {ECO:0000256|RuleBase:RU361227}. CC -!- SUBUNIT: Interacts (via C-terminus) with host IRF3; this CC interaction leads to IRF3 degradation. Interacts with host IRF7; CC this interaction leads to IRF7 degradation. CC {ECO:0000256|RuleBase:RU361227}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytoskeleton CC {ECO:0000256|RuleBase:RU361227}. CC -!- DOMAIN: The zinc-finger domain is important, but not sufficient CC for binding and degrading IRF3. It is sometimes described as a CC RING zinc-finger, but it is atypical and it is unclear whether it CC is related with ubiquitin ligase activity. CC {ECO:0000256|RuleBase:RU361227}. CC -!- SIMILARITY: Belongs to the rotavirus A NSP1 family. CC {ECO:0000256|RuleBase:RU361227}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ454631; AJA72669.1; -; Genomic_RNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0039548; P:suppression by virus of host IRF3 activity; IEA:UniProtKB-KW. DR GO; GO:0039557; P:suppression by virus of host IRF7 activity; IEA:UniProtKB-KW. DR GO; GO:0039644; P:suppression by virus of host NF-kappaB transcription factor activity; IEA:UniProtKB-KW. DR InterPro; IPR002148; Rotavirus_NSP1. DR Pfam; PF00981; Rota_NS53; 1. PE 3: Inferred from homology; KW Host cytoplasm {ECO:0000256|RuleBase:RU361227}; KW Host cytoskeleton {ECO:0000256|RuleBase:RU361227}; KW Host-virus interaction {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host IRF3 by virus {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host IRF7 by virus {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host NF-kappa-B by virus KW {ECO:0000256|RuleBase:RU361227}; KW Inhibition of host RLR pathway by virus KW {ECO:0000256|RuleBase:RU361227}; KW Interferon antiviral system evasion {ECO:0000256|RuleBase:RU361227}; KW Metal-binding {ECO:0000256|RuleBase:RU361227}; KW RNA-binding {ECO:0000256|RuleBase:RU361227}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU361227}; KW Zinc {ECO:0000256|RuleBase:RU361227}; KW Zinc-finger {ECO:0000256|RuleBase:RU361227}. FT NON_TER 1 1 {ECO:0000313|EMBL:AJA72669.1}. SQ SEQUENCE 483 AA; 57242 MW; 7E267C3688A50092 CRC64; FKDACYYYKR INKLNHAVLK LGVNDTWRPS PPTKYKGWCL DCCQHTDLTY CRGCTMYHVC QWCSQYDRCF LDNQPHLLRM RTFKNEVTKN DLFNLIDMYN ILFPINQRIV DKFISSTRQH KCRNECMTQW YNHLLMPITL QSLSIELDGD VYYVFGYYDS MRDVNQTPFS FTNLIDMYDK LLLDNVNFNR MSFLPVALQQ EYALRYFSKS RFISEKRKCI SDLHFSTNVI ENLHNPSFKI QITRNCSELS SDWNGACKLI KDMNNYFNVL KTSHIEFYSI STRCRMFTQY KLKIASKHIK PNYVTSNHRT SATEVHNCKW CSINNGYTVW NDFRIKKIYD NIFNFLRALV KSNSNIGHCS SQEKIYEHVK NVLDVCNDEK WKMAVAEIFN CLEPVELDTA KYVLFNHEVN WDVINLLVQS VGKVPQILTL NDIIIIMKSI IYEWFDIRYM RNTPMTTFTV DKLRQLCTGV KTIVYDSGIS DIE //