ID A0A0C4DGR5_HUMAN Unreviewed; 512 AA. AC A0A0C4DGR5; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 14-DEC-2022, entry version 55. DE SubName: Full=Zinc finger protein 496 {ECO:0000313|Ensembl:ENSP00000473324.1}; DE Flags: Fragment; GN Name=ZNF496 {ECO:0000313|Ensembl:ENSP00000473324.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000473324.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000473324.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0007829|PubMed:18220336} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18220336; DOI=10.1021/pr0705441; RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.; RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient RT phosphoproteomic analysis."; RL J. Proteome Res. 7:1346-1351(2008). RN [3] {ECO:0007829|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [4] {ECO:0007829|PubMed:28112733} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). RN [5] {ECO:0000313|Ensembl:ENSP00000473324.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC104335; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; A0A0C4DGR5; -. DR SMR; A0A0C4DGR5; -. DR PeptideAtlas; A0A0C4DGR5; -. DR Antibodypedia; 20839; 162 antibodies from 26 providers. DR Ensembl; ENST00000461277.2; ENSP00000473324.1; ENSG00000162714.13. DR HGNC; HGNC:23713; ZNF496. DR VEuPathDB; HostDB:ENSG00000162714; -. DR GeneTree; ENSGT00940000161967; -. DR ChiTaRS; ZNF496; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000162714; Expressed in sural nerve and 167 other tissues. DR ExpressionAtlas; A0A0C4DGR5; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd07765; KRAB_A-box; 1. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR027767; Zfp496. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR23226:SF180; ZINC FINGER PROTEIN 496; 1. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 2. DR SMART; SM00355; ZnF_C2H2; 5. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Proteomics identification {ECO:0007829|MaxQB:A0A0C4DGR5, KW ECO:0007829|PeptideAtlas:A0A0C4DGR5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00042}. FT DOMAIN 146..216 FT /note="KRAB" FT /evidence="ECO:0000259|PROSITE:PS50805" FT DOMAIN 331..359 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 360..387 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 388..415 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 447..475 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 478..505 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT REGION 185..207 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 283..324 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 413..438 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 302..324 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000473324.1" SQ SEQUENCE 512 AA; 58121 MW; BBDC6FEF08D66A11 CRC64; QAVAAVEALE REPGRPWQWL KHCEDPVVID DGDSPLDQEQ EQLPVEPHSD LAKNQDAQPI TLAQCLGLPS RPPSQLSGDP VLQDAFLLQE ENVRDTQQVT TLQLPPRIFQ FNNHRSNGYI LEMLGSGGKK AQIISVLSQI YVSRVSPFKD MILCFSEEDW SLLDPAQTGF YGEFIIGEDY GVSMPPNDLA AQPDLSQGEE NEPRVPELQD LQGKEVPQVS YLDSPSLQPF QVEERRKREE LQVPEFQACP QTVVPQNTYP AGGNPRSLEN SLDEEVTIEI VLSSSGDEDS QHGPYCTEEL GSPTEKQRSL PASHRSSTEA GGEVQTSKKS YVCPNCGKIF RWRVNFIRHL RSRREQEKPH ECSVCGELFS DSEDLDGHLE SHEAQKPYRC GACGKSFRLN SHLLSHRRIH LQPDRLQPVE KREQAASEDA DKGPKEPLEN GKAKLSFQCC ECGKAFQRHD HLARHRSHFH LKDKARPFQC RYCVKSFTQN YDLLRHERLH MKRRSKQALN SY //