ID A0A0C4DGR5_HUMAN Unreviewed; 512 AA. AC A0A0C4DGR5; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 16-MAR-2016, entry version 12. DE SubName: Full=Zinc finger protein 496 {ECO:0000313|Ensembl:ENSP00000473324}; DE Flags: Fragment; GN Name=ZNF496 {ECO:0000313|Ensembl:ENSP00000473324}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000473324, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000473324, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., RA Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000213|PubMed:18220336} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18220336; DOI=10.1021/pr0705441; RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.; RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for RT efficient phosphoproteomic analysis."; RL J. Proteome Res. 7:1346-1351(2008). RN [3] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [4] {ECO:0000313|Ensembl:ENSP00000473324} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2015) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSP00000473324}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC104335; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR UniGene; Hs.654803; -. DR Ensembl; ENST00000461277; ENSP00000473324; ENSG00000162714. DR HGNC; HGNC:23713; ZNF496. DR GeneTree; ENSGT00820000127022; -. DR Proteomes; UP000005640; Chromosome 1. DR ExpressionAtlas; A0A0C4DGR5; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR Gene3D; 3.30.160.60; -; 5. DR InterPro; IPR027775; C2H2_Znf_fam. DR InterPro; IPR001909; KRAB. DR InterPro; IPR027767; Zfp496. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR015880; Znf_C2H2-like. DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd. DR PANTHER; PTHR10032; PTHR10032; 2. DR PANTHER; PTHR10032:SF212; PTHR10032:SF212; 2. DR Pfam; PF01352; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 5. DR SUPFAM; SSF109640; SSF109640; 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Metal-binding {ECO:0000256|SAAS:SAAS00516022}; KW Nucleus {ECO:0000256|SAAS:SAAS00417074}; KW Proteomics identification {ECO:0000213|EPD:A0A0C4DGR5, KW ECO:0000213|MaxQB:A0A0C4DGR5, ECO:0000213|PeptideAtlas:A0A0C4DGR5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00516025}; KW Zinc {ECO:0000256|SAAS:SAAS00516021}; KW Zinc-finger {ECO:0000256|SAAS:SAAS00516023}. FT DOMAIN 146 216 KRAB. {ECO:0000259|PROSITE:PS50805}. FT DOMAIN 331 359 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT DOMAIN 360 387 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT DOMAIN 388 415 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT DOMAIN 447 475 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT DOMAIN 478 505 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000473324}. SQ SEQUENCE 512 AA; 58121 MW; BBDC6FEF08D66A11 CRC64; QAVAAVEALE REPGRPWQWL KHCEDPVVID DGDSPLDQEQ EQLPVEPHSD LAKNQDAQPI TLAQCLGLPS RPPSQLSGDP VLQDAFLLQE ENVRDTQQVT TLQLPPRIFQ FNNHRSNGYI LEMLGSGGKK AQIISVLSQI YVSRVSPFKD MILCFSEEDW SLLDPAQTGF YGEFIIGEDY GVSMPPNDLA AQPDLSQGEE NEPRVPELQD LQGKEVPQVS YLDSPSLQPF QVEERRKREE LQVPEFQACP QTVVPQNTYP AGGNPRSLEN SLDEEVTIEI VLSSSGDEDS QHGPYCTEEL GSPTEKQRSL PASHRSSTEA GGEVQTSKKS YVCPNCGKIF RWRVNFIRHL RSRREQEKPH ECSVCGELFS DSEDLDGHLE SHEAQKPYRC GACGKSFRLN SHLLSHRRIH LQPDRLQPVE KREQAASEDA DKGPKEPLEN GKAKLSFQCC ECGKAFQRHD HLARHRSHFH LKDKARPFQC RYCVKSFTQN YDLLRHERLH MKRRSKQALN SY //