ID A0A0B7NX27_HUMAN Unreviewed; 366 AA. AC A0A0B7NX27; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 05-JUN-2019, entry version 25. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CEP25304.1}; GN Name=HLA-C {ECO:0000313|EMBL:CEP25304.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CEP25304.1}; RN [1] {ECO:0000313|EMBL:CEP25304.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28547825; DOI=10.1111/tan.13057; RA Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., RA Dahl A., Winkler S., Lange V., Bohme I., Schmidt A.H.; RT "Dual redundant sequencing strategy: Full-length gene characterisation RT of 1056 novel and confirmatory HLA alleles."; RL HLA 90:79-87(2017). CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LN811477; CEP25304.1; -; Genomic_DNA. DR PeptideAtlas; A0A0B7NX27; -. DR ChiTaRS; HLA-C; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00292284}; KW Immunity {ECO:0000256|SAAS:SAAS00292276}; KW Membrane {ECO:0000256|SAAS:SAAS00291594, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00291591}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00298758, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00292275, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002135727. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 297 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT REGION 337 366 Disordered. {ECO:0000256|MobiDB-lite: FT A0A0B7NX27}. FT COMPBIAS 340 359 Polar. {ECO:0000256|MobiDB-lite: FT A0A0B7NX27}. SQ SEQUENCE 366 AA; 41003 MW; FBD67BBBEB016553 CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEARSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYREGLCVE WLRRYLKNGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA //