ID A0A0B5KPZ3_9HIV1 Unreviewed; 192 AA. AC A0A0B5KPZ3; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 18-JUL-2018, entry version 17. DE RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341}; GN Name=vif {ECO:0000313|EMBL:AJG38616.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AJG38616.1, ECO:0000313|Proteomes:UP000101665}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AJG38616.1, ECO:0000313|Proteomes:UP000101665} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=R463MPL_I32 {ECO:0000313|EMBL:AJG38616.1}; RX PubMed=25569444; RA Yue L., Pfafferott K.J., Baalwa J., Conrod K., Dong C.C., Chui C., RA Rong R., Claiborne D.T., Prince J.L., Tang J., Ribeiro R.M., RA Cormier E., Hahn B.H., Perelson A.S., Shaw G.M., Karita E., RA Gilmour J., Goepfert P., Derdeyn C.A., Allen S.A., Borrow P., RA Hunter E.; RT "Transmitted Virus Fitness and Host T Cell Responses Collectively RT Define Divergent Infection Outcomes in Two HIV-1 Recipients."; RL PLoS Pathog. 11:E1004565-E1004565(2015). CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}; CC Peripheral membrane protein {ECO:0000256|RuleBase:RU003341, CC ECO:0000256|SAAS:SAAS01059686}; Cytoplasmic side CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}. CC Host cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059682}. CC Note=In the cytoplasm, seems to colocalize with intermediate CC filament vimentin. A fraction is associated with the cytoplasmic CC side of cellular membranes, presumably via the interaction with CC Pr55Gag precursor. {ECO:0000256|RuleBase:RU003341}. CC -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein CC family. {ECO:0000256|RuleBase:RU003341, CC ECO:0000256|SAAS:SAAS01059764}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP223781; AJG38616.1; -; Genomic_RNA. DR Proteomes; UP000101665; Genome. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0019058; P:viral life cycle; IEA:InterPro. DR HAMAP; MF_04081; HIV_VIF; 1. DR InterPro; IPR000475; Viral_infect. DR Pfam; PF00559; Vif; 1. DR PRINTS; PR00349; VIRIONINFFCT. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000101665}; KW Host cell membrane {ECO:0000256|SAAS:SAAS01059755}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS01059745}; KW Host membrane {ECO:0000256|SAAS:SAAS01059757}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01059733}; KW Membrane {ECO:0000256|SAAS:SAAS01059748}; KW Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01059744}; KW Virion {ECO:0000256|SAAS:SAAS01059762}. SQ SEQUENCE 192 AA; 22769 MW; 1B52F005D0341A48 CRC64; MENRWQVMIV WQVDRMRIRT WNSLVKYHMY RSKKAKRWFY RHHYESNHPK VSSEVHIPLG EARLVVRTYW GLHTGERDWQ LGHGVSIEWR LRRYNTQIDP ELADQLIHLH YFACFSESAI RKAILGQVVS PSCEYQAGHN KVGSLQYLAL KALVTPTREK PPLPSVRKLT EDRWNKPQKT RGHRGSHTMN GC //