ID A0A0B5KI09_9HIV1 Unreviewed; 204 AA. AC A0A0B5KI09; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 22-NOV-2017, entry version 11. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS00118351}; GN Name=nef {ECO:0000313|EMBL:AJG38385.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AJG38385.1, ECO:0000313|Proteomes:UP000130432}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AJG38385.1, ECO:0000313|Proteomes:UP000130432} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=R463FPL_d248_C18 {ECO:0000313|EMBL:AJG38385.1}; RX PubMed=25569444; RA Yue L., Pfafferott K.J., Baalwa J., Conrod K., Dong C.C., Chui C., RA Rong R., Claiborne D.T., Prince J.L., Tang J., Ribeiro R.M., RA Cormier E., Hahn B.H., Perelson A.S., Shaw G.M., Karita E., RA Gilmour J., Goepfert P., Derdeyn C.A., Allen S.A., Borrow P., RA Hunter E.; RT "Transmitted Virus Fitness and Host T Cell Responses Collectively RT Define Divergent Infection Outcomes in Two HIV-1 Recipients."; RL PLoS Pathog. 11:E1004565-E1004565(2015). CC -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00536203}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00536205}; Lipid-anchor CC {ECO:0000256|SAAS:SAAS00536205}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS00536205}. CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344, CC ECO:0000256|SAAS:SAAS00536190}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP223754; AJG38385.1; -; Genomic_RNA. DR Proteomes; UP000130432; Genome. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor. DR InterPro; IPR027481; HIV-1_Nef_core_sf. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000130432}; KW Host cell membrane {ECO:0000256|SAAS:SAAS00004523}; KW Host membrane {ECO:0000256|SAAS:SAAS00118235}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00004502}; KW Lipoprotein {ECO:0000256|RuleBase:RU000344}; KW Membrane {ECO:0000256|SAAS:SAAS00004519}; KW Myristate {ECO:0000256|RuleBase:RU000344}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. SQ SEQUENCE 204 AA; 23341 MW; 53A504C129A84AC0 CRC64; MGGKWSKRSI VGWPEVRERI RRTPPAATGV GAVSQDLDKH GAITSTNINH PSCVWLEAQE EGEVGFPVRP QVPLRPMTYK AALDLSHFLK EKGGLDGLIY SRKRQEILDL WVYNTQGFFP DWQNYTPGPG PRFPLTFGWC FKLVPVDPEE VEKATEGEDN SLLHPLCQHG MDDEEGETLR WRFDSYLAFK HIARETHPEF YKDC //