ID   A0A0B5CM78_OSCCA        Unreviewed;       585 AA.
AC   A0A0B5CM78;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   19-JAN-2022, entry version 23.
DE   SubName: Full=Frizzled B {ECO:0000313|EMBL:AJE25509.1};
OS   Oscarella carmela (Sponge).
OC   Eukaryota; Metazoa; Porifera; Homoscleromorpha; Homosclerophorida;
OC   Oscarellidae; Oscarella.
OX   NCBI_TaxID=386100 {ECO:0000313|EMBL:AJE25509.1};
RN   [1] {ECO:0000313|EMBL:AJE25509.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25801223; DOI=10.1111/ede.12115;
RA   Schenkelaars Q., Fierro-Constain L., Renard E., Hill A.L., Borchiellini C.;
RT   "Insights into Frizzled evolution and new perspectives.";
RL   Evol. Dev. 17:160-169(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC       {ECO:0000256|ARBA:ARBA00008077}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR   EMBL; KM365034; AJE25509.1; -; mRNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.2000.10; -; 1.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR000539; Frizzled/Smoothened_TM.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like.
DR   PANTHER; PTHR11309; PTHR11309; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   Pfam; PF01392; Fz; 1.
DR   PRINTS; PR00489; FRIZZLED.
DR   SMART; SM00063; FRI; 1.
DR   SMART; SM01330; Frizzled; 1.
DR   SUPFAM; SSF63501; SSF63501; 1.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00090};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..585
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002100867"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        533..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..162
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   DOMAIN          249..561
FT                   /note="G_PROTEIN_RECEP_F2_4"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   DISULFID        36..97
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        44..90
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ   SEQUENCE   585 AA;  65354 MW;  F2C98CCD6C339CAC CRC64;
     MLLPALLFAA LAALFNSPVR VEAVDAVPDW VRRANCYEMN VDTCAGIGYN TTLLPNRFGH
     RTLPEAALEI STYVPLIQFK CSPELRFMAC ATFLPICTTD PVTNAKRTLP PCRQMCQRVQ
     TGCEPVVKRW LRGVAWPAAL SCDELPDEMD SLEDGTPPCF DNATQYAIDI PGGPDSGFNT
     TYPPLLPAEE GTEVTVNNSQ LLAKRDSCYR YMSGRKTEGF LCINCNYDEQ AKPGESAGYY
     FKQEDIAFAN YWVGIWAVLC FLSTLFTCLT FLIDRDRFHY PERPIIYLAV CYCVFSLGFI
     ARLFAGDERI ACDQTHGILI KADANHAGCT AIFMVLYFSM MAASVWWVVL TVTWFLAAGM
     KWSNEAIESL ALYYHLVAWI VPLIMTIVAL ILQKIDADEL TRVCFVGAQD VNAMAGFVVA
     PLALFLVVGT IFIIAGFAAL FRIREVIKSD RSRSGKLEKL MIRIGVFSVL YTVPATIVIG
     CYFYEYFARN LWSVHTAPQW NQLGDSSNKT FTFNGDVPST CPQDDSCTQA LPAVFYIKFL
     MSLIVGVTSG VWIWSSKTLA TWNSFISKSC SRLNRGKDRR NETTV
//