ID A0A0B4LF37_DROME Unreviewed; 1306 AA. AC A0A0B4LF37; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 27-MAR-2024, entry version 53. DE SubName: Full=No mechanoreceptor potential A, isoform F {ECO:0000313|EMBL:AHN56110.1}; GN Name=nompA {ECO:0000313|EMBL:AHN56110.1, GN ECO:0000313|FlyBase:FBgn0016047}; GN Synonyms=Dmel\CG13207 {ECO:0000313|EMBL:AHN56110.1}, nomp GN {ECO:0000313|EMBL:AHN56110.1}, Nomp-A {ECO:0000313|EMBL:AHN56110.1}, GN NOMPA {ECO:0000313|EMBL:AHN56110.1}, NompA GN {ECO:0000313|EMBL:AHN56110.1}, y {ECO:0000313|EMBL:AHN56110.1}; GN ORFNames=CG13207 {ECO:0000313|EMBL:AHN56110.1, GN ECO:0000313|FlyBase:FBgn0016047}, Dmel_CG13207 GN {ECO:0000313|EMBL:AHN56110.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AHN56110.1; -; Genomic_DNA. DR RefSeq; NP_001286312.1; NM_001299383.1. DR DNASU; 45587; -. DR EnsemblMetazoa; FBtr0339483; FBpp0308565; FBgn0016047. DR GeneID; 45587; -. DR KEGG; dme:Dmel_CG13207; -. DR AGR; FB:FBgn0016047; -. DR CTD; 45587; -. DR FlyBase; FBgn0016047; nompA. DR VEuPathDB; VectorBase:FBgn0016047; -. DR OrthoDB; 2872850at2759; -. DR BioGRID-ORCS; 45587; 0 hits in 1 CRISPR screen. DR GenomeRNAi; 45587; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0016047; Expressed in embryonic labial sensory complex (Drosophila) and 7 other cell types or tissues. DR ExpressionAtlas; A0A0B4LF37; baseline and differential. DR GO; GO:0031012; C:extracellular matrix; IDA:FlyBase. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase. DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:FlyBase. DR GO; GO:0050954; P:sensory perception of mechanical stimulus; IMP:FlyBase. DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase. DR CDD; cd01099; PAN_AP_HGF; 4. DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4. DR InterPro; IPR003609; Pan_app. DR InterPro; IPR001507; ZP_dom. DR PANTHER; PTHR47327:SF13; APPLE DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR47327; FI18240P1-RELATED; 1. DR Pfam; PF00024; PAN_1; 4. DR SMART; SM00473; PAN_AP; 4. DR SMART; SM00241; ZP; 1. DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 4. DR PROSITE; PS50948; PAN; 5. DR PROSITE; PS51034; ZP_2; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..25 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 26..1306 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002107554" FT TRANSMEM 1125..1150 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 29..138 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 148..232 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 239..323 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 347..426 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 660..761 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 774..1016 FT /note="ZP" FT /evidence="ECO:0000259|PROSITE:PS51034" FT REGION 436..628 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 715..737 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 516..531 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 565..589 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1306 AA; 146116 MW; A4DCBAD56204361E CRC64; MRPRKGIHVL LTTLVVSLSL SKINGQTTCK NGLGRVLYER LPNQQLQGYD DDVVRDTAPP FRVLEKCQDL CLRDRSGSNN LVRTCTSFDF QPGSRITSFG GNSEYEESLC YLTSEQAGPE GIGSLMLVPN SVHFNEICLT SSRPERECPS RRYVFERHPR KKLKLPISDI KEITAANRSD CEDKCLNEFS FVCRSANFDS TMRSCTLSRF TRRTHPELME DDPNSDYLEN TCLNAERRCD GLAVFVKEEN KRLGGPFEVD IFNNMTLEEC QTMCLRAEKY FCRSVEFDDQ SKQCILSEED SISQKDDISI SSSPTHHFYD LVCLDNQRAN DYPDNSVTSH LFSSGRRPDT AFQRYRNSRL GGEFHSEITG RSLSECLDEC LRQTSFQCRS AVYSDRFRTC RLSRYNQKDG MRIIYDADYD YYENLMLNVV GGGADGDGGG HGGSSDGKRP GDQSGSNWRQ PNKHDDRYGS GGSSVGGGSH GGTGSGGSRL PPGEGVDYGR PYDRYPDIAG NEYDRNPYGG DRDRDRYPPD RYGSRYPTGG DGIGYNRPYD RFPDDYGLER PPPPFYDYDY EERYGDRYGP YDREYDGPPG RRPPSGGPYG RYDSPFNRPY GGNGLDDRPL PLPGLGLSHP PTPYGGGGAG HVGVGVGVNS GPPRPPITRC EESDNFKQIA ARHKMRRHFV RRALIVPSLI QCERECIESR DFVCRSFNYR DSAASGYEDR DRDRDRDSPN CELSDRDSRE LDIHDPGTFD ASNYDFYERS IGRSDGECMD VTQTCNEEGM EFTIRTPEGF LGRIYTYGFY DRCFFRGNGG TVNVLRLSGP QGYPDCGTQR YGDTLTNIVV VQFSDNVQTS RDKRYNLTCI FRGPGEAVVS SGYIGAGSGS PIPIEYLPAE NTLSSKVRLS ILYQGRPTTT IAVGDPLTFR LEAQDGYNHV TDIFATNVVA RDPYSGRSIQ LIDRFGCPVD PFVFPELDKL RDGDTLEARF NAFKIPESNF LVFEATVRSC REGCQPAYCP GPAGRQEPSF GRRRRSLNTT EIPEPEALAL EGSSQLEAST LDEVTVVNST TVSATLGQVP LNETQLGEKT KETEEPEQVR EMIEVFETRE EIEKESYPRK LVAPVETVCM TPAEYHGLIT AIILLMILLF SITLVAGLGY RRYWKSISKN RLVDRHSPIH SLGHSHSSIR THERFTEIGH MPNLNGGGGG AAAGTGGGAN QSASNRASNA FRTNMSMFGG SLHKTFATGN LARMCQLPVI NPMRSTNQSS HQFEDPSEPI YTDPSLFERS RQVADHSVTH PQNEFPTTVR NYRCEV //