ID A0A0B4KEH7_DROME Unreviewed; 2409 AA. AC A0A0B4KEH7; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 02-JUN-2021, entry version 50. DE SubName: Full=CAP, isoform Y {ECO:0000313|EMBL:AGB93393.1}; GN Name=CAP {ECO:0000313|EMBL:AGB93393.1, GN ECO:0000313|FlyBase:FBgn0033504}; GN Synonyms=cap {ECO:0000313|EMBL:AGB93393.1}, CG18409 GN {ECO:0000313|EMBL:AGB93393.1}, CG3451 {ECO:0000313|EMBL:AGB93393.1}, GN DCAP {ECO:0000313|EMBL:AGB93393.1}, Dmel\CG18408 GN {ECO:0000313|EMBL:AGB93393.1}, Rexin {ECO:0000313|EMBL:AGB93393.1}, GN rexin {ECO:0000313|EMBL:AGB93393.1}, Vinexin GN {ECO:0000313|EMBL:AGB93393.1}; GN ORFNames=CG18408 {ECO:0000313|EMBL:AGB93393.1, GN ECO:0000313|FlyBase:FBgn0033504}, Dmel_CG18408 GN {ECO:0000313|EMBL:AGB93393.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AGB93393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AGB93393.1; -; Genomic_DNA. DR RefSeq; NP_001260860.1; NM_001273931.1. DR SMR; A0A0B4KEH7; -. DR DNASU; 36084; -. DR EnsemblMetazoa; FBtr0336696; FBpp0307677; FBgn0033504. DR GeneID; 36084; -. DR CTD; 36084; -. DR FlyBase; FBgn0033504; CAP. DR BioGRID-ORCS; 36084; 0 hits in 3 CRISPR screens. DR ChiTaRS; CAP; fly. DR GenomeRNAi; 36084; -. DR Proteomes; UP000000803; Chromosome 2R. DR ExpressionAtlas; A0A0B4KEH7; baseline and differential. DR GO; GO:0016203; P:muscle attachment; IMP:FlyBase. DR GO; GO:0050954; P:sensory perception of mechanical stimulus; IMP:FlyBase. DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR Pfam; PF00018; SH3_1; 1. DR Pfam; PF14604; SH3_9; 2. DR SMART; SM00326; SH3; 3. DR SUPFAM; SSF50044; SSF50044; 3. DR PROSITE; PS50002; SH3; 3. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}. FT DOMAIN 2152..2211 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 2221..2280 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 2350..2409 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT REGION 1..276 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 288..330 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 354..376 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 493..527 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 558..600 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 675..918 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1066..1159 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1188..1318 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1385..1405 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1540..1589 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1711..1741 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1768..1876 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2013..2050 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1364..1384 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1598..1622 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 2077..2097 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 17..36 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..83 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 84..100 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 110..134 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 180..275 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 290..330 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 359..376 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 503..518 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 558..584 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 585..600 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 693..711 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 712..735 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 747..766 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 775..798 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 800..818 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 819..855 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 856..895 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1068..1082 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1091..1106 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1129..1159 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1191..1209 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1258..1291 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1719..1735 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1777..1797 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1819..1835 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1854..1876 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2034..2050 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2409 AA; 271531 MW; 02B32C2FEAAE0954 CRC64; MPNNRNRNRN RNRNKRNRNQ NQNQNPSQNQ NENHQQQAEG AEDREEQQDF QTQIAVAQSS SFVDDNGNSG SVSNGPTENS EEVTNTLEKT EKKEEIFEQP ATVIQKEADS DAEMGAKNSK HRKEKSDKQA SNGKSEEQVR PPPTIIRRPP GSPRQAKVIV HRIVREEDTA NGKAQSPEPP KAVESKEQHM EVEDSKKEKP EAQQEIETKE ERENEPSPKE LPESSHLSED AQQKHVEVEE NQQVYDEVDY SKDETTDNNP QQEQHDSKEP EQYVLQLEKA MEFVENAHQQ HVAAVQSYQK QRDTEQNAQQ QEQNEAQHLQ ESTKAHQQNI AVPQILVDPK KREEGLAQQL HHDVKEEPIL NNAQQQNDDT APKSPKEVTI KVQFQTEDPY SQQPPPQKPT SKVIIHQIHV ETTDEEQNAK PTFEEVSSTT GSLAGTLSPP PRYLVESPKN VSSGQFSNFS RNVQIQEMEL NSDFSSGEFN SLQSPLVCEV DSESEGSVVL GPERSPSDQQ VPSSSRVEQH EQVRQKRAQY RNALESHFMP QLLNPRYLDS ILEENEWRNS TASSGGSDQT GIRTPKLNET FPRSQLDFSR RHKRREEAPS PLKLETKLLE ESTDLESCTR LQSALSPQSE DAELVYLSSS ASSSVSDLME LELEQAAALA ERALVDLDTD ASRLIARPDD EMSSTSTTTA DRSETEAETE TETEREGEQS RESTPVNANP TLASSQSSLL SAATPTPTPT PTPADREQLA KDTNVSGGST VSFGAASPLA ATREEFVRNM DKVRELIEMT RREQEQGELP RSPSPPPVPP PPASVPPYSP ESSSFHLASL QLKRQESNDS HCSDSTTHSQ CTAINLASPP PPPTAQPPTP PLRQKPAPPP VPQPVSPPAP PTPQSEPELS VADSVANANA DVDADADTDT EAIKKLRLLC TEQLASMPYG EQVLEELASV AQNISDQSQN KMPYPMPQLP HIKELQLNAN ESKSSSAWLG LPTQSDPKLL VCLSPGQRDL VNNQTQPDDL LDAHQKFVER RGYHELSKAQ VLEQDHQQQQ SEMLKTAAMM RELRKSLSPP APPVPPPPVP VKSAETAAKA TAHENAKRDD ASEQKQKIAA CESSSLENKP RRAADLGAQQ SAEQRQSSST TTSSHKATTE TMSSDTAKFP TLDSMESELA RMFPQHKGDI FEEQRKRFSN IEFPSHQPVS QTKRYSNIET SSYESKKRME NGQVVYDVST SSHEKKEQGD PPKDQPVPPV PPPPIMSATK LNGNTFIDGD VAPKNSQPSR ESGSGSGNGT YEEFRQRAKA AADAFGEQRE QQNGLDQDRV FKDFDRLSQQ MHAELQSTRE KREKSASMYD LSGFTRPASG HPRLDELQQR RHAHMQELER EIERSAKSRQ ERMSSVPRQM EATPPRTHEI PIELEPRSRR AESLCNLNEP PPRPHTTVGH YNHPVVQDDW SRYANDLGYS ENIARPFARE VEICYQRQNQ RTPHCIRAPR LSASTNDLSS SSQYSYDTFN AYGGRRTHAP MLNQAQQQQR PHYGSCYSMI ERDPNPRYIS TTSRRGVSPA PPPVATPQQQ QVPPPAYDRQ QRRSSLPREL HEQQLKYILS KEEELKFEVE RLQQERRRLM EEMQRAPVLP APQRRESYRP AAKLPTLSED EVFRQQMAEE WMNKVAEREE RRQHKIIRIS KIEDEHDHSA VDKATISDEF LDRVKERRHK LSMPADSDWE SGAESQPQPA AQSQPESDVE APPVRILEGQ AEANLRQLPR HLREFAKFST SEQLPDGAQM ERHEEQERRE EATDNAHSSA TKKTSIVKTY KVSRLPPSVQ AFERSSSNSE LQRPFVRRQL SDASRPAYRP NEVTRPSYKS NGYVSEPEPN YDSDYSTVRY RTQNPHRVQS VSSAVNVRNL NQDEKLYGTM PNPIKSAQNS YKNQPGRIEN YTTGHSSVSE KEKKEWWDEV MDIFNGNLEQ SKLSPLYTEG NLSRALAKES GYTSDSNLVF RKKEVPVSSP LSPVEQKQAY KSLQAGGEPP LLGFRKPAPE KPRDLDPNAP PIPPQPPVKG LSSYDFPYST DTVDGSDVNI HFKTPIRHEQ RQNLSEEELA IRQAEHMQKL YHEERRRKYL QELQDMNSRR HTDNFTPSQK SPIALNRYDD FPTDVTLKSL VGPKTVARAL FNFQGQTSKE LSFRKGDTIY IRRQIDANWY EGEHNAMIGL LPASYVEIVS RDGARTPSKR PSEGQARAKY NFQAQSGIEL SLNKGELVTL TRRVDGNWFE GKIANRKGIF PCSYVEVLTD IGAEDIAART TTVITSQSTT NLRPNLDVLR TNINNEFNTL TQNGAQPPNG ILKETRTLHK TDALHVDTSS EPLAYRALYK YRPQNSDELE LLEGDVVHVL EKCDDGWFVG TSQRTGCFGT FPGNYVERA //