ID A0A0B4K885_DROME Unreviewed; 389 AA. AC A0A0B4K885; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 27-MAR-2024, entry version 61. DE SubName: Full=Kenny, isoform B {ECO:0000313|EMBL:AFH08256.1}; GN Name=key {ECO:0000313|EMBL:AFH08256.1, GN ECO:0000313|FlyBase:FBgn0041205}; GN Synonyms=dIKK {ECO:0000313|EMBL:AFH08256.1}, dIKK-gamma GN {ECO:0000313|EMBL:AFH08256.1}, dIKKgamma GN {ECO:0000313|EMBL:AFH08256.1}, Dmel\CG16910 GN {ECO:0000313|EMBL:AFH08256.1}, DmIKK-gamma GN {ECO:0000313|EMBL:AFH08256.1}, DmIKKgamma GN {ECO:0000313|EMBL:AFH08256.1}, Dmikkgamma GN {ECO:0000313|EMBL:AFH08256.1}, dmIKKgamma GN {ECO:0000313|EMBL:AFH08256.1}, IKK {ECO:0000313|EMBL:AFH08256.1}, GN IKK-gamma {ECO:0000313|EMBL:AFH08256.1}, IKK[[gamma]] GN {ECO:0000313|EMBL:AFH08256.1}, IKKG {ECO:0000313|EMBL:AFH08256.1}, GN IKKg {ECO:0000313|EMBL:AFH08256.1}, IKKgamma GN {ECO:0000313|EMBL:AFH08256.1}, Ikkgammabeta GN {ECO:0000313|EMBL:AFH08256.1}, Kenny {ECO:0000313|EMBL:AFH08256.1}, GN KEY {ECO:0000313|EMBL:AFH08256.1}, Key {ECO:0000313|EMBL:AFH08256.1}; GN ORFNames=CG16910 {ECO:0000313|EMBL:AFH08256.1, GN ECO:0000313|FlyBase:FBgn0041205}, Dmel_CG16910 GN {ECO:0000313|EMBL:AFH08256.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AFH08256.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AFH08256.1; -; Genomic_DNA. DR RefSeq; NP_001246503.1; NM_001259574.2. DR AlphaFoldDB; A0A0B4K885; -. DR SMR; A0A0B4K885; -. DR EnsemblMetazoa; FBtr0305672; FBpp0296952; FBgn0041205. DR GeneID; 37967; -. DR AGR; FB:FBgn0041205; -. DR CTD; 37967; -. DR FlyBase; FBgn0041205; key. DR VEuPathDB; VectorBase:FBgn0041205; -. DR OMA; VAMRKNF; -. DR OrthoDB; 5406882at2759; -. DR PhylomeDB; A0A0B4K885; -. DR BioGRID-ORCS; 37967; 0 hits in 3 CRISPR screens. DR ChiTaRS; key; fly. DR GenomeRNAi; 37967; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0041205; Expressed in embryonic/larval hemocyte (Drosophila) and 22 other cell types or tissues. DR ExpressionAtlas; A0A0B4K885; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd09803; UBAN; 1. DR Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1. DR InterPro; IPR032419; CC2-LZ_dom. DR InterPro; IPR034735; NEMO_ZF. DR PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1. DR PANTHER; PTHR31553:SF1; NF-KAPPA-B ESSENTIAL MODULATOR; 1. DR Pfam; PF16516; CC2-LZ; 1. DR PROSITE; PS51801; ZF_CCHC_NOA; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0B4K885}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU01142}. FT DOMAIN 357..387 FT /note="CCHC NOA-type" FT /evidence="ECO:0000259|PROSITE:PS51801" FT REGION 324..360 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 160..259 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 295..322 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 324..339 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 389 AA; 44134 MW; 6D3FB7875B950F0C CRC64; MSDEESFVIL GSSPCSSLMP DSSLRSDVCG NAQEAKETVA STSTQPPTVN CIPVSITASQ QQHKSLDSGS SQQQSLATSF IMGEIQSDVL KNSVYSQFPS LCSLQGSAEE VVKLQNMMTE YLALKSTLDK VNQTMLNYHN LTQQWRQEAA DREHQYKEHV KECQAQIAIL RVENQELKRD LETKIEQIEG VHTIRLKEQD ELRKSVSEKQ SLIDNMRVEI DKLKQLNHSF EFVPEYATES KSQELIKKMQ LDINELKARD IQKQEVIKGL QIQNDIYRRD FEMERADREK NAGEKDQYLM DLRSLQRRNQ ELIEALAESH KASKACSTAS PLSSSRSNLR EEQRPVRILD PTGASSRTSD TTLRCPICSK SFNALSVLQS HVNDCLDKN //