ID A0A0B4K7S0_DROME Unreviewed; 2773 AA. AC A0A0B4K7S0; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 10-APR-2019, entry version 40. DE SubName: Full=Fat facets, isoform D {ECO:0000313|EMBL:AFH06704.1}; DE SubName: Full=Fat facets, isoform G {ECO:0000313|EMBL:AFH06707.1}; DE SubName: Full=Fat facets, isoform H {ECO:0000313|EMBL:AHN57626.1}; GN Name=faf {ECO:0000313|EMBL:AFH06704.1, GN ECO:0000313|FlyBase:FBgn0005632}; GN Synonyms=BcDNA.LD22582 {ECO:0000313|EMBL:AFH06704.1}, BcDNA:LD22582 GN {ECO:0000313|EMBL:AFH06704.1}, Dmel\CG1945 GN {ECO:0000313|EMBL:AFH06704.1}, Faf {ECO:0000313|EMBL:AFH06704.1}, Fat GN {ECO:0000313|EMBL:AFH06704.1}, P55824 {ECO:0000313|EMBL:AFH06704.1}, GN USPX {ECO:0000313|EMBL:AFH06704.1}; GN ORFNames=CG1945 {ECO:0000313|EMBL:AFH06704.1, GN ECO:0000313|FlyBase:FBgn0005632}, Dmel_CG1945 GN {ECO:0000313|EMBL:AFH06704.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AFH06704.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AFH06704.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AFH06704.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AFH06704.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=10.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:AFH06704.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=10.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:AFH06704.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the peptidase C19 family. CC {ECO:0000256|SAAS:SAAS01045498}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AFH06704.1; -; Genomic_DNA. DR EMBL; AE014297; AFH06707.1; -; Genomic_DNA. DR EMBL; AE014297; AHN57626.1; -; Genomic_DNA. DR RefSeq; NP_001247387.1; NM_001260458.1. DR RefSeq; NP_001247390.1; NM_001260461.1. DR RefSeq; NP_001287627.1; NM_001300698.1. DR UniGene; Dm.3133; -. DR SMR; A0A0B4K7S0; -. DR EnsemblMetazoa; FBtr0307547; FBpp0300199; FBgn0005632. DR EnsemblMetazoa; FBtr0307550; FBpp0300202; FBgn0005632. DR EnsemblMetazoa; FBtr0339188; FBpp0308326; FBgn0005632. DR GeneID; 43749; -. DR CTD; 43749; -. DR FlyBase; FBgn0005632; faf. DR eggNOG; KOG1866; Eukaryota. DR eggNOG; COG5077; LUCA. DR GeneTree; ENSGT00940000168609; -. DR OrthoDB; 625455at2759; -. DR ChiTaRS; faf; fly. DR GenomeRNAi; 43749; -. DR Proteomes; UP000000803; Chromosome 3R. DR ExpressionAtlas; A0A0B4K7S0; baseline and differential. DR GO; GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; IEA:InterPro. DR GO; GO:0016579; P:protein deubiquitination; IEA:InterPro. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR038765; Papain_like_cys_pep_sf. DR InterPro; IPR001394; Peptidase_C19_UCH. DR InterPro; IPR018200; USP_CS. DR InterPro; IPR028889; USP_dom. DR Pfam; PF00443; UCH; 1. DR SUPFAM; SSF48371; SSF48371; 1. DR SUPFAM; SSF54001; SSF54001; 1. DR PROSITE; PS00972; USP_1; 1. DR PROSITE; PS00973; USP_2; 1. DR PROSITE; PS50235; USP_3; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 1668 2062 USP. {ECO:0000259|PROSITE:PS50235}. SQ SEQUENCE 2773 AA; 310598 MW; 0E1B5EB7D56C77BE CRC64; MTFDTRRHTT GQPGSTAPSS SSSTTSTTTT TTSPAQSAGS GSGIGTGTGT VANSSLPGGG SGSLDGNQDQ QPATDSQSSD DVAASLSANS VDSTITIVPP EKLISSFPTT KLRSLTQKIS NPRWVVPVLP EQELEVLLNA AIELTQAGVD HDCEPCVEFY RNGLSTSFAK ILTDEAVNSW KNNIHHCILV SCGKLLHLIA IHMQRDNPYL LDLLAIVFDP ENKFNTFNAG RQPECFAAPD YIWGQLDSNK MYARPPPEPK NARGWLVDLI NRFGQLGGFD NLLERFNIGL ELLKRNQNKC TGKNISVEGR VENGAQDNRL TLALIHSLLR PFGQCYELLM PATIAKYFMP TWNVVLDLLD SFTDEELKRE VKPEGRNDYI NGIVKSARLL ASRLTGQEEL IRDLEMFRLK MILRLLQVSS FNGKMNALNE INKVLSSVAY FSHRSQPLPH CMPEDEMDWL TADRMAQWIK SSDVLGVVLK DSLHQPQYVE KLEKIIRFLI KEQALTLDDL DAVWRAQAGK HEAIVKNVHD LLAKLAWDFT PEQLDHLFEA FQASMTTANK RQRERLLELI RRLAEDDKNG VMAQKVLKLF WTLAHSQEVP PEVLDQALGA HVKILDYSCS QERDAQKTIW LDKCVDELKS GDGWVLPALR LIRDICCLYD TTTNHAQRTQ TSTNRQQVIE RLQNDYSLVI LVTNSLTAYM EKVRQMVTDS PGLDATRILI DGRFPHHVQI AERLEFLKFL LKDGQLWLCA DQAKQIWHCL AVNAVFPADR EECFRWFGKL MGEEPDLDPG INKDFFENNI LQLDPHLLTE SGIKCFERFF KAVNSKEDKL KAIHRGYMLD NEDLIGKDYL WRVITTGGEE IASKAIDLLK EVSTALGPRL QENIAEFHEM FIGECCSRLR THYGNIVILG KTQLQEELDA PDQSDNTNDE SKDSKMRFIE AEKMCRILKV LQEYVKECDR SFSGDRVHLP LSRVTRGKNT ILYIRFQNPG RSIDDMEIVT HSNETMAAFK RNLLKRIKGT STANIKVDLF YANDEMIGVS DEINPLYQYT IRDKMNLTAK LTPVGTGLAS SPDSSSDSST GSPPRPCPDM QRVESESTLP GVIISQNYQY TEFFLKLYQL GSDLEHGRLR DSAKVLLHLL PCDRQTIRQL KIMCKVPKAA VTVAVTGDKI AKDEEEKLYP TEQAGIEDEE EHCTPEQMFL HPTPAQVLYN LSVLHGLLIP ALDPLGESAL LVQSAWMHSG CAHFVLELLT KNNFLPSADM HTKRASFQCV LRLAKLFLYI VGSVLSRVGD EPMICDLDNG SRSQVDILKQ NFSTMPSSSQ GTLRAISAKL AVILAREMLS ASPEGDRCRT LFSSTLQWSC PDISTIKAVV QLAWASSCGN LQALGNSSGD FEDEVIVPDG QDFSMCKEAL EVLTISFILN PSANEALTSD PNWPKFITSI VLKNPLRHVR QVASEQLFLA STYCAGDRRP FVYMVNLLVG ALKTLVPQYE STCAEFFSVL CRTLSYGCIY NWPLQISEGL LGDEIKWLQR IRENVHATGD TQVHEELLEG HLCLAKELMF FLGADSKAQL NELIHELIDD FLFTASREFL HLRRHGSLRQ DTVPPPVCRS PHTIAAACDL LIALCQLCVP NMKLLTNTLI DFVCTDTDPL REWDYLPPVG ARPTKGFCGL KNAGATCYMN SVLQQLYMVP AVRVGILRAH GAATTDGEDF SGDSDLTGGG LGSALFSGPA SALVSLPSSS STIEDGLHDV RKNYHVVILK HVQAIFAHLG HSALQYYVPR GLWTHFKLLG EPVNLREQQD AVEFFMSLLE SLDEGLKALG QPQLMNATLG GSFSDQKICQ ECPHRYSKEE PFSVFSVDIR NHSSLTESLE QYVKGELLEG ADAYHCDKCD KKVVTVKRVC VKKLPPVLAI QLKRFEYDYE RVCAIKFNDY FEFPRILDME PYTVSGLAKL EGEVVEVGDN CQTNVETTKY ELTGIVVHSG QASGGHYFSY ILSKNPANGK CQWYKFDDGE VTECKMHEDE EMKAECFGGE YMGETYDNNL KRMQYRRQKR WWNAYMLFYT RCDQTPVQYE PSVEQLSLAE SRNMVLPLPK PIERSVRHQN IRFLHSRSIF SVEFFNFIKK LVSCNLLSAR SNKITPAAEE LSLLGVQLAS QFLFHTGFRT KKSLRGPVME WYDALSHHIR SSALVRKWFA NHALLSPPSR LGEYILMAPS PDVRTVFVKL VVFFCHFAIN DEPLTGYDGA NLCEQVLISV LRLLKSEAAD YGKHLPHYFS LFSMYVGLGT REKQQLLRLN VPLQFIQVAL DDGPGPAIKY QYPEFSKLHQ VVSHLIRCSD VSEKCQSSNQ NARPLSNPFK DPNVAHEELT PLSTECMDLL FNRTGYIKKV IEDTNVGDEG LKLLQYCSWE NPHFSRAVLT ELLWQCGFAY CHDMRHHTDL LLNILLIDDS WQHHRIHNAL NGVAEEREGL LETIQRAKTH YQKRAYQIIK CLTQLFHKSP IALQMLHTNS NITRHWSIAV EWLQGELDRQ RGIGCQYNSY SWSPPAQSND NTNGYMLERS QSAKNTWSMA FELCPDEDEN NEPNLETNMD ENKSEPVAQP GGVLEGSTGG TEQLPENKTP TTSSPSTAAW PARGDSNAIP RLSRQLFGAY TSTGSGSTSG GSAPTSALTT TAGSGANSET ESSAQETTGE TTINGLTNSL DQMEITAKKK CRRVIIKKLV ESKDEEDATT ATTAATTEVT TSPATAIATA ATLEPAGMSE LTTMVEKNLI ISQENPQAKS SLQ //