ID A0A0B4K719_DROME Unreviewed; 5134 AA. AC A0A0B4K719; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 02-DEC-2020, entry version 47. DE SubName: Full=Ryanodine receptor, isoform I {ECO:0000313|EMBL:AFH07966.1}; GN Name=RyR {ECO:0000313|EMBL:AFH07966.1, GN ECO:0000313|FlyBase:FBgn0011286}; GN Synonyms=D-RyR {ECO:0000313|EMBL:AFH07966.1}, Dmel\CG10844 GN {ECO:0000313|EMBL:AFH07966.1}, DmRyR {ECO:0000313|EMBL:AFH07966.1}, GN DRR {ECO:0000313|EMBL:AFH07966.1}, DRY {ECO:0000313|EMBL:AFH07966.1}, GN dry {ECO:0000313|EMBL:AFH07966.1}, dRyR {ECO:0000313|EMBL:AFH07966.1}, GN dRyr {ECO:0000313|EMBL:AFH07966.1}, dya {ECO:0000313|EMBL:AFH07966.1}, GN l(2)k00424 {ECO:0000313|EMBL:AFH07966.1}, l(2)k04913 GN {ECO:0000313|EMBL:AFH07966.1}, Rya-44F {ECO:0000313|EMBL:AFH07966.1}, GN Rya-r4 {ECO:0000313|EMBL:AFH07966.1}, Rya-R44F GN {ECO:0000313|EMBL:AFH07966.1}, Rya-r44F {ECO:0000313|EMBL:AFH07966.1}, GN rya-r44F {ECO:0000313|EMBL:AFH07966.1}, Rya-r76CD GN {ECO:0000313|EMBL:AFH07966.1}, RYR {ECO:0000313|EMBL:AFH07966.1}, Ryr GN {ECO:0000313|EMBL:AFH07966.1}, ryr {ECO:0000313|EMBL:AFH07966.1}, RyRs GN {ECO:0000313|EMBL:AFH07966.1}; GN ORFNames=CG10844 {ECO:0000313|EMBL:AFH07966.1, GN ECO:0000313|FlyBase:FBgn0011286}, Dmel_CG10844 GN {ECO:0000313|EMBL:AFH07966.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AFH07966.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane CC protein {ECO:0000256|ARBA:ARBA00004326}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AFH07966.1; -; Genomic_DNA. DR RefSeq; NP_001246211.1; NM_001259282.2. DR EnsemblMetazoa; FBtr0304572; FBpp0293114; FBgn0011286. DR GeneID; 49090; -. DR CTD; 49090; -. DR FlyBase; FBgn0011286; RyR. DR GeneTree; ENSGT00940000168850; -. DR PhylomeDB; A0A0B4K719; -. DR BioGRID-ORCS; 49090; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 49090; -. DR Proteomes; UP000000803; Chromosome 2R. DR ExpressionAtlas; A0A0B4K719; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro. DR CDD; cd12877; SPRY1_RyR; 1. DR CDD; cd12878; SPRY2_RyR; 1. DR CDD; cd12879; SPRY3_RyR; 1. DR Gene3D; 2.60.120.920; -; 3. DR InterPro; IPR001870; B30.2/SPRY. DR InterPro; IPR043136; B30.2/SPRY_sf. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR014821; Ins145_P3_rcpt. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR036300; MIR_dom_sf. DR InterPro; IPR016093; MIR_motif. DR InterPro; IPR013662; RIH_assoc-dom. DR InterPro; IPR000699; RIH_dom. DR InterPro; IPR013333; Ryan_recept. DR InterPro; IPR003032; Ryanodine_rcpt. DR InterPro; IPR009460; Ryanrecept_TM4-6. DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf. DR InterPro; IPR035761; SPRY1_RyR. DR InterPro; IPR035764; SPRY2_RyR. DR InterPro; IPR035762; SPRY3_RyR. DR InterPro; IPR003877; SPRY_dom. DR Pfam; PF08709; Ins145_P3_rec; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF02815; MIR; 1. DR Pfam; PF08454; RIH_assoc; 1. DR Pfam; PF06459; RR_TM4-6; 1. DR Pfam; PF01365; RYDR_ITPR; 2. DR Pfam; PF02026; RyR; 4. DR Pfam; PF00622; SPRY; 3. DR PRINTS; PR00795; RYANODINER. DR SMART; SM00472; MIR; 4. DR SMART; SM00449; SPRY; 3. DR SUPFAM; SSF100909; SSF100909; 1. DR SUPFAM; SSF47473; SSF47473; 1. DR SUPFAM; SSF49899; SSF49899; 2. DR SUPFAM; SSF82109; SSF82109; 2. DR PROSITE; PS50188; B302_SPRY; 3. DR PROSITE; PS50919; MIR; 5. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Calcium channel {ECO:0000256|ARBA:ARBA00022673}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0B4K719}; KW Receptor {ECO:0000313|EMBL:AFH07966.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 4466..4486 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 4657..4675 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 4740..4762 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 4929..4951 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 5005..5028 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 94..148 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 155..200 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 210..264 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 270..328 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 336..394 FT /note="MIR" FT /evidence="ECO:0000259|PROSITE:PS50919" FT DOMAIN 577..803 FT /note="B30.2/SPRY" FT /evidence="ECO:0000259|PROSITE:PS50188" FT DOMAIN 1032..1217 FT /note="B30.2/SPRY" FT /evidence="ECO:0000259|PROSITE:PS50188" FT DOMAIN 1452..1673 FT /note="B30.2/SPRY" FT /evidence="ECO:0000259|PROSITE:PS50188" FT REGION 1416..1453 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1477..1511 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2286..2306 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3594..3615 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3808..3830 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3863..3893 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4550..4576 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4611..4630 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4697..4721 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 460..480 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1421..1453 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3808..3824 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 5134 AA; 581413 MW; 240F77DCF56EF7D3 CRC64; MAEAEGGSEQ DDVSFLRTED MVTLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHHNS DMYLACLSTS SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE NEQSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG QNIVIYEGGV VMAQARSLWR LELARTKWTG GFINWYHPMR IRHITTGRYL GVNDSNELIL VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH CETSLWLSYK SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK TARVIRKCSS LFTQFITALE TLQSNRRHSI FFQKVNLNEM VMCLEDLINY FSQPEDDMEH EEKQNRFRAL RNRQDLFQEE GVLNLILEAI DKINIITSQG FLASFLAGDE TGQSWDLIST YLYQLLAAII KGNHTNCAQF ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASIRP NIFVGRVDGS SMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTSGYVPYPG GGKKWGGNGV GDDLYSFGFD GAFLWTGGRK TLVVDALPEE PFIRKGDVIG VAIDLSVPII TFTFNGVKVR GSFRDFNLDG MFFPVMSCSS KLSCRFLFGG DHGRLKFAPP MGFSALVQCL MPQQILSLDP CFYFGNLAKN VLAGPWLIED DTAFVPKPVD TTGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR DDYHRIHPCL THFEKLPAAE KRYDNQLAVQ TLKTIISLGY YITMDKPPAR IRPVRLPNEI FMQGNGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR ERIQQGWTYG LNEDSENHRS PHLVPYAKVD EAIKKANRDT ASETVRTLLV YGYVLDPPTG EGTEALLAEA QRLKFAGFRT YRVERNYAVT SGKWYFEFEV LTSGPMRVGW ARADCYPGAM LGSEDTSWAF DGHNEEKVYG GVSESFGKQC GPGDIVGVFL DLADHTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC TLGVGQKARL IYGQDVDSLK FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ PIFENTEEMP DCRIDVTRIP GGADTPPHLK ISHNTFETME KANWEFLRLS LPVTCMGEFI SEQEKARRWD EIKNRQYRLM REAEIAAQMQ VQTQAAHMDH MLKGGFNMND IKGLTRNFDE HADAEADHMM RGPNRPPRKG SLTRNITFET DMSAALDEMQ RSTSVLDMNG LGEEMDDKKK RGRSPFKFFS KKSRDQSREK MGARTLDTSL ERRNTVAHGR NVVNQQMTTR APTLRLNNAE IPPSPVPQGP KQLSGSNLGQ QPVETSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG WVTTQYHLHS REFNKNKVRR GSVYIEDDYE MAIERIDRQS CYVVRADELF NEVTQDASGK GASQGMFVGC FVDTATGIIR FTCEGKDTSH RWMMEPDTKL FPAIFVEATS KEILQIELGR TPTTLPLSAA VLPTSDKHIN PQSPPRLKVQ CLRPHQWARV PNTALQVHAL KLSDVRGWSM LCEDPVSMLA LHIPEEDRCI DILELIEMDK LLSFHAHSLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI RSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYITPL GAELKELYSD EEMQHSLRSL VTESVRPQLR MTEITPPVIA TSSMPSVSSE PIPDIDQLYS PKFPLEVVRQ FVMEALKDAV EINQVHNRDP IGWTNENLFL PLIKLTDRLL LVGVLTDEDV QRLLVMIDPE TWDQAFEREG KDEHRKGLLT MKMAEGAKLQ MCYLLHHLYD TQLRHRVESI IAFSHDFVGD LQTDQLRRYI EIKQSDLPSA VAAKKTKEFR CPPREQMNQI LCFKNLEPDD QDNCTCGLEL RGRLGDFHDS LMQKVSLNAL QEPDGVEGTA IEEVKTGPIT KIYNFINTVK ELEEGPKEVE EPEKKTPEEV FRKVLIKTIV SWAEESQIEN PKLVREMFSL LLRQYDTVGE LVRALEKTYV INTRARDDVA EMWVGLSQIR ALLPVQMSQE EEELMRKRLW KLVNNATFFQ HPDLIRILRV HENVMAVMMN TLGRRAQAQS DAPTQSEVAE GAPSKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD FLLDNANILL ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE LVEKGYPDLG WDPVEGERYL DFLRYCVWVN GESVEENANL VIRLLIRRPE CLGPALRGEG EGLFRAIVEA NRMSERISDR CKMQDEAEGT IAGLNFTHPL PEGEEDEDYI DTGAAILNFY CTLVDLLGRC APDASVIEQG KNESLRARAI LRSLVPLEDL QGVLSLKFTL SQTAPGEEKP KSDMPSGLLP NNKQSIVLFL ERVYGIEAQD LFYRLLEDAF LPDLRTATIL DKSDGSESDM ALAMNRYIGN SILPLLIKHS KFYNEAENYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF LVALTSQMQP AMLLKLLRKL TVDVSKLSEY TTVALRLLTL HFDRCAKYYG STQGQGSYGA SSDEEKRLTM LLFSNIFDSL SNMDYDPELF GKALPCLIAI GCALPPDYSL SKNTDEDYYG RQMGAPDQPQ YMPNPIDTNN VHLDNDLNSL VQKFSEHYHD AWASRRLEGG WTYGDIRSDN DRKHPRLKPY NMLSEYERER YRDPVRECLK GLLAIGWTVE HSEVEVALNH RGSTRRQSKP QINEFQNEGS PFNYNPHPVD MSNLTLSREM QNMAERLAEN SHDIWAKKKN EELNGCGGVI HPQLVPYDLL TDKEKKKDRE RSQEFLKYMQ YQGYKLHKPS KGGAVEEGGA TQAAVELRFS YSLLEKLIQY LDRATINMKL LKPSTTFSRR SSFKTATRDI KFFSKVVLPL MEKYFSTHRN YFIAIATATN NIGAASLKEK EMVASIFCKL AALLRNRLSA FGPDVRITVR CLQVLVKGID ARTLTKNCPE FIRTSMLTFF NQTSDDLGNT ILNLQDGKYS HLRGTHLKTS TSLGYVNQVV LPVLTAMFDH LAACDYGSDL LLDEIQVASY KILAALYHLG TDGTLTHDRK YLKTEIERHR PALGSCLGAY SSCFPVAFLE PHLNKHNQYS LLNRIADHSL EAQDIMVKME SCMPNLETIL AEVDQFVESD KTYNDAPHII DVILPLLCAY LPFWWSQGPD NVSPTSGNHV TMVTADHMNP LLRNVLKMIK KNIGNDNAPW MTRIAAYTQQ IIINTSEELL KDPFLPLAER VKKRTENMLH KEDSMRGFIK SATDDTSQVE TQLQEDWNLL VRDIYSFYPL LIKYVDLQRN HWLKDNIPEA EELYNHVAEI FNIWSKSQYF LKEEQNFISA NEIDNMALIM PTATRRSAIS EGAPAVGGKV KKKKKNRDKK RDKDKEVQAS LMVACLKRLL PVGLNLFAGR EQELVQHCKD RYLKKMPEYD VIEFARNQLT LPDKLDPSDE MSWQHYLYSK LGKTEEPVDE QALEKANVNS NEKGKDKTQE TVDRIVAMAK VLFGLHMAAS SKNRSKRWGS KISVARRQAV ISSLRAKHLY RMSRHRACNI FARSYYEQWL QEENVGQEVM VEDLTQTFED SEKSKKEGEE TDSKPDPLTQ LVTTFCRGAM TERSGALQED LLYMSYAQIA AKSTGKEEEE GGDEEGGEGG EEGEGTSIHE QEMEKQKLLF HQARLSNRGV AEMVLLHISA SKGIPSEMVM TTLNLGIAIL RGGNIDIQMG MLNHLKEKKD VGFFTSIAGL MNSCSVLDLD AFERNTKAEE YIPSAGAGLG VGSEGAAGEK NMHDAEFTCA LFRFIQLTCE GHNLEWQNYL RTQAGNTTTV NVVICTVDYL LRLQESIMDF YWHYSSKEII DPAGKANFFK AIEVASQVFN TLTEVIQGPC TLNQQALAHS RLWDAVGGFL FLFSHMQDKL SKHSSQVDLL KELLNLQKDM ITMMLSMLEG NVVNGTIGKQ MVDTLVESAS NVELILKYFD MFLKLADLIE SPSFHEVDMK NEGWVTPKDF REKMEQSKNY TPEEMDFLLA CCERNHEGKI DYRAFVEHFH EPSKEIGFNL AVLLTNLSEH MPNEPRLARF LETAGSVLNY FEPFLGRIEI LGSSKRIERV YFEIKDSNIE QWEKPQIRES KRAFFYSIVT EGGDKEKLEA FVNFCEDAIF EMTHASGLMA TDDGGGNVKR DTAYSSYMSE EEEERAARDP IRRTITAVKE GLKFGVHMLS PANIKHQIGV MQTKSIPELI VGFFKIIFYI FYYTGYAHFC VVRYIFGILL NLMRGPAPEQ EEEPVVEEET FGRALPPLPL EEPPGTVQAF GLDINKEENG MYKVVVHESP ANSSMEEGGE SSPEDGAAAS GELVEGEPHQ EPISIVDLLG GEAAKKAAQE RQEAQKAQEA AMASIEAEAK KSSSAPQETP AVHQIDFSQY THRAVSFLAR NFYNLKYVAL VLAFSINFML LFYKVTSFTE EADSSAEEEL ILGSGSGGGA DITGSGFGGS GDGGSGDGEM EDEIPELVHV DEDFFYMEHV LRIAACLHSL VSLAMLIAYY HLKVPLAIFK REKEIARRLE FEGLFIAEQP EDDDFKSHWD KLVISAKSFP VNYWDKFVKK KVRQKYSETY DFDSISNLLG MEKSTFAAQE SEETGIFKYI MNIDWRYQVW KAGVTFTDNA FLYSLWYFSF SVMGNFNNFF FAAHLLDVAV GFKTLRTILQ SVTHNGKQLV LTVMLLTIIV YIYTVIAFNF FRKFYIQEED EEVDKKCHDM LTCFVFHLYK GVRAGGGIGD EIGDPDGDDY EVYRIIFDIT FFFFVIIILL AIIQGLIIDA FGELRDQLES VKDNMESNCF ICGMGKDFFD IVPHGFDTHV QKEHNLANYM FFLMHLINKP DTEYTGQETY VWNMYQQRSW DFFPVGDCFR KQYEDELSGG GGGG //