ID A0A0B1YCZ5_9BACI Unreviewed; 263 AA. AC A0A0B1YCZ5; DT 04-MAR-2015, integrated into UniProtKB/TrEMBL. DT 04-MAR-2015, sequence version 1. DT 19-JAN-2022, entry version 32. DE RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|ARBA:ARBA00018080, ECO:0000256|HAMAP-Rule:MF_00134}; DE Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362, ECO:0000256|HAMAP-Rule:MF_00134}; GN Name=trpC {ECO:0000256|HAMAP-Rule:MF_00134}; GN ORFNames=PI85_04750 {ECO:0000313|EMBL:KHK54626.1}; OS Lysinibacillus sp. A1. OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus; OC unclassified Lysinibacillus. OX NCBI_TaxID=1571920 {ECO:0000313|EMBL:KHK54626.1, ECO:0000313|Proteomes:UP000030963}; RN [1] {ECO:0000313|EMBL:KHK54626.1, ECO:0000313|Proteomes:UP000030963} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A1 {ECO:0000313|EMBL:KHK54626.1, RC ECO:0000313|Proteomes:UP000030963}; RA Chen J.W., Yin W.F., Chan K.G.; RT "Draft Genome of Lysinibacillus A1."; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O; CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48; CC Evidence={ECO:0000256|ARBA:ARBA00001633, ECO:0000256|HAMAP- CC Rule:MF_00134}; CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L- CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696, CC ECO:0000256|HAMAP-Rule:MF_00134}. CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000256|ARBA:ARBA00008737, CC ECO:0000256|HAMAP-Rule:MF_00134}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KHK54626.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JSZM01000007; KHK54626.1; -; Genomic_DNA. DR RefSeq; WP_036119186.1; NZ_JSZM01000007.1. DR EnsemblBacteria; KHK54626; KHK54626; PI85_04750. DR GeneID; 29441205; -. DR UniPathway; UPA00035; UER00043. DR Proteomes; UP000030963; Unassembled WGS sequence. DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule. DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule. DR CDD; cd00331; IGPS; 1. DR Gene3D; 3.20.20.70; -; 1. DR HAMAP; MF_00134_A; IGPS_A; 1. DR HAMAP; MF_00134_B; IGPS_B; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR045186; Indole-3-glycerol_P_synth. DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom. DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS. DR InterPro; IPR011060; RibuloseP-bd_barrel. DR PANTHER; PTHR22854; PTHR22854; 1. DR Pfam; PF00218; IGPS; 1. DR SUPFAM; SSF51366; SSF51366; 1. DR PROSITE; PS00614; IGPS; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605, ECO:0000256|HAMAP- KW Rule:MF_00134}; KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141, KW ECO:0000256|HAMAP-Rule:MF_00134}; KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793, ECO:0000256|HAMAP- KW Rule:MF_00134}; KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00134}; KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822, ECO:0000256|HAMAP- KW Rule:MF_00134}. FT DOMAIN 4..254 FT /note="IGPS" FT /evidence="ECO:0000259|Pfam:PF00218" SQ SEQUENCE 263 AA; 28663 MW; E1DC952B39BD0F57 CRC64; MNILQKILQQ KRIEVGALLE QPDPLANFSE QQRPSLFQSL RQANTLQVIA EMKRASPSKG LIAGGADPVA QAKVYAQAGA AAISVLTEKE FFKGSFEDLA AVARAVDKPL LCKDFMVDRV QIRFAKAAGA SIILLIVAAL TDEALRDLYS YATSLGLEVL VEVHDSEELK RALAVDAKLI GVNNRDLRTF EVNLQRTKEI AEAFPFDEEH LLISESGIWS QDDAKQVAAM GASGVLVGEA LMRSEDVGLA LRRLQVQTEE TSV //