ID A0A0A7DW42_LYCBA Unreviewed; 604 AA. AC A0A0A7DW42; DT 04-MAR-2015, integrated into UniProtKB/TrEMBL. DT 04-MAR-2015, sequence version 1. DT 27-MAR-2024, entry version 28. DE RecName: Full=prolycopene isomerase {ECO:0000256|ARBA:ARBA00012419}; DE EC=5.2.1.13 {ECO:0000256|ARBA:ARBA00012419}; GN Name=CRTISO {ECO:0000313|EMBL:AIX87497.1}; OS Lycium barbarum (Barbary matrimony-vine). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Lycieae; Lycium. OX NCBI_TaxID=112863 {ECO:0000313|EMBL:AIX87497.1}; RN [1] {ECO:0000313|EMBL:AIX87497.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25511605; RA Liu Y., Zeng S., Sun W., Wu M., Hu W., Shen X., Wang Y.; RT "Comparative analysis of carotenoid accumulation in two goji ( Lycium RT barbarum L. and L. ruthenicum Murr.) fruits."; RL BMC Plant Biol. 14:269-269(2014). CC -!- CATALYTIC ACTIVITY: CC Reaction=7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene; CC Xref=Rhea:RHEA:30971, ChEBI:CHEBI:15948, ChEBI:CHEBI:62466; CC EC=5.2.1.13; Evidence={ECO:0000256|ARBA:ARBA00000004}; CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|ARBA:ARBA00001974}; CC -!- COFACTOR: CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; CC Evidence={ECO:0000256|ARBA:ARBA00001911}; CC -!- COFACTOR: CC Name=NADP(+); Xref=ChEBI:CHEBI:58349; CC Evidence={ECO:0000256|ARBA:ARBA00001937}; CC -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis. CC {ECO:0000256|ARBA:ARBA00004900}. CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane CC {ECO:0000256|ARBA:ARBA00004258}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004258}. CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family. CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF957684; AIX87497.1; -; mRNA. DR AlphaFoldDB; A0A0A7DW42; -. DR UniPathway; UPA00803; -. DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046608; F:carotenoid isomerase activity; IEA:InterPro. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:InterPro. DR Gene3D; 3.90.660.50; -; 1. DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1. DR InterPro; IPR002937; Amino_oxidase. DR InterPro; IPR014101; CrtISO. DR InterPro; IPR045892; CrtISO-like. DR InterPro; IPR036188; FAD/NAD-bd_sf. DR NCBIfam; TIGR02730; carot_isom; 1. DR PANTHER; PTHR46313; -; 1. DR PANTHER; PTHR46313:SF3; PROLYCOPENE ISOMERASE, CHLOROPLASTIC; 1. DR Pfam; PF01593; Amino_oxidase; 1. DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1. PE 2: Evidence at transcript level; KW FAD {ECO:0000256|ARBA:ARBA00022827}; KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}; KW Isomerase {ECO:0000313|EMBL:AIX87497.1}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857}. FT DOMAIN 96..576 FT /note="Amine oxidase" FT /evidence="ECO:0000259|Pfam:PF01593" SQ SEQUENCE 604 AA; 66326 MW; 6BB215960949BF54 CRC64; MGTLNFMFPN SLLDGTCKIV ALGDNKLRYN KKRSSCFDPL RIGNCTDHQA KGRKGGSVLK LKAVVDVDKR VESYGSSDVE GNESGSYDAI VIGSGIGGLV AATQLAVKGA KVLVLEKYVI PGGSSGFYQK DGYTFDVGSS VMFGFSDKGN LNLITQALAA VGCKLEVIPD PTTVHFHLPN DLSVRIHREY DDFIEELVSK FPHEKEGINK FYSECWKIFN SLNSLELKSL EEPIYLFGQF FKKPLECLTL AYYLPQNAGD IARKYIRDPG LLSFIDAECF IVSTVNALQT PMINASMVLC DRHFGGINYP VGGVGEIAKS LAKGLVDQGS QILYRANVTS IILDNGKAVG VKLSDGRKFY AKTIVSNATR WDTFGKLLKA ENLPKEEENF QKAYVKAPSF LSIHMGVKAD VLPPDTDCHH FILEDNWTNL EKPYGSIFLS IPTVLDSSLA PEGQHILHIF TTSSIEDWEG LSRKDYEAKK ELVTERIISR LEKTLFPGLK SSIVFKEVGT PKTHRRYLAR DSGTYGPMPR GTPKGLLGMP FNTTAIDGLY CVGDSCFPGQ GVIAVAFSGV MCAHRVAADL GFEKKSDVLD SGLLRLLAWL RTLA //