ID A0A0A6YWR5_MOUSE Unreviewed; 223 AA. AC A0A0A6YWR5; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 5. DT 02-JUN-2021, entry version 45. DE SubName: Full=LIM/homeobox protein Lhx4 {ECO:0000313|Ensembl:ENSMUSP00000141662}; DE Flags: Fragment; GN Name=Lhx4 {ECO:0000313|Ensembl:ENSMUSP00000141662, GN ECO:0000313|MGI:MGI:101776}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000141662, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000141662, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141662, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000141662} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141662}; RG Ensembl; RL Submitted (DEC-2014) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR SMR; A0A0A6YWR5; -. DR ProteomicsDB; 310133; -. DR Antibodypedia; 20587; 374 antibodies. DR Ensembl; ENSMUST00000195275; ENSMUSP00000141662; ENSMUSG00000026468. DR MGI; MGI:101776; Lhx4. DR GeneTree; ENSGT00940000157906; -. DR HOGENOM; CLU_027802_5_1_1; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000026468; Expressed in head and 118 other tissues. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR001781; Znf_LIM. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00412; LIM; 1. DR SMART; SM00389; HOX; 1. DR SMART; SM00132; LIM; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 1. DR PROSITE; PS50023; LIM_DOMAIN_2; 1. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE- KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}. FT DOMAIN 26..89 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 94..154 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 96..155 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 166..223 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 173..188 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 223 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000141662" SQ SEQUENCE 223 AA; 25374 MW; EA7890001AF5F54C CRC64; MQLADRCFSR AGSVYCKEDF FKRFGTKCTA CQQGIPPTQV VRKAQDFVYH LHCFACIICN RQLATGDEFY LMEDGRLVCK EDYETAKQND DSEAGAKRPR TTITAKQLET LKNAYKNSPK PARHVREQLS SETGLDMRVV QVWFQNRRAK EKRLKKDAGR HRWGQFYKSV KRSRGGSKQE KESSAEDCGV SDSELSFRGE QGWRGEAEAL GETLGDTNPG PQE //