ID A0A0A6YWR5_MOUSE Unreviewed; 224 AA. AC A0A0A6YWR5; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 4. DT 16-MAR-2016, entry version 14. DE SubName: Full=LIM/homeobox protein Lhx4 {ECO:0000313|Ensembl:ENSMUSP00000141662}; DE Flags: Fragment; GN Name=Lhx4 {ECO:0000313|Ensembl:ENSMUSP00000141662, GN ECO:0000313|MGI:MGI:101776}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000141662, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000141662, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141662, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000141662} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141662}; RG Ensembl; RL Submitted (DEC-2014) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000682}. CC -!- SIMILARITY: Contains 1 LIM zinc-binding domain. CC {ECO:0000256|RuleBase:RU000350}. CC -!- SIMILARITY: Contains LIM zinc-binding domains. CC {ECO:0000256|SAAS:SAAS00113226}. CC -!- SIMILARITY: Contains homeobox DNA-binding domain. CC {ECO:0000256|SAAS:SAAS00113315}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000141662}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC117598; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC121314; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10090.ENSMUSP00000027740; -. DR PaxDb; A0A0A6YWR5; -. DR Ensembl; ENSMUST00000195275; ENSMUSP00000141662; ENSMUSG00000026468. DR MGI; MGI:101776; Lhx4. DR eggNOG; KOG4577; Eukaryota. DR eggNOG; ENOG410XPDC; LUCA. DR GeneTree; ENSGT00760000118921; -. DR Proteomes; UP000000589; Chromosome 1. DR ExpressionAtlas; A0A0A6YWR5; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR Gene3D; 1.10.10.60; -; 1. DR Gene3D; 2.10.110.10; -; 2. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR009057; Homeodomain-like. DR InterPro; IPR001781; Znf_LIM. DR Pfam; PF00046; Homeobox; 1. DR Pfam; PF00412; LIM; 1. DR SMART; SM00389; HOX; 1. DR SMART; SM00132; LIM; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 1. DR PROSITE; PS50023; LIM_DOMAIN_2; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW DNA-binding {ECO:0000256|RuleBase:RU000682, KW ECO:0000256|SAAS:SAAS00474877}; KW Homeobox {ECO:0000256|RuleBase:RU000682, KW ECO:0000256|SAAS:SAAS00474775}; KW LIM domain {ECO:0000256|RuleBase:RU000350, KW ECO:0000256|SAAS:SAAS00474985}; KW Metal-binding {ECO:0000256|RuleBase:RU000350, KW ECO:0000256|SAAS:SAAS00516478}; KW Nucleus {ECO:0000256|RuleBase:RU000682, KW ECO:0000256|SAAS:SAAS00474951}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Zinc {ECO:0000256|RuleBase:RU000350, ECO:0000256|SAAS:SAAS00516446}. FT DOMAIN 26 89 LIM zinc-binding. {ECO:0000259|PROSITE: FT PS50023}. FT DOMAIN 94 154 Homeobox DNA-binding. FT {ECO:0000259|PROSITE:PS50071}. FT NON_TER 224 224 {ECO:0000313|Ensembl:ENSMUSP00000141662}. SQ SEQUENCE 224 AA; 25432 MW; 0FBA7890001AF5F5 CRC64; MQLADRCFSR AGSVYCKEDF FKRFGTKCTA CQQGIPPTQV VRKAQDFVYH LHCFACIICN RQLATGDEFY LMEDGRLVCK EDYETAKQND DSEAGAKRPR TTITAKQLET LKNAYKNSPK PARHVREQLS SETGLDMRVV QVWFQNRRAK EKRLKKDAGR HRWGQFYKSV KRSRGGSKQE KESSAEDCGV SDSELSFRGE QGWRGEAEAL GETLGDTNPG PQEG //