ID A0A0A6YW07_MOUSE Unreviewed; 208 AA. AC A0A0A6YW07; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 12-OCT-2022, entry version 46. DE RecName: Full=Inositol-1-monophosphatase {ECO:0000256|RuleBase:RU364068}; DE EC=3.1.3.25 {ECO:0000256|RuleBase:RU364068}; GN Name=Impa1 {ECO:0000313|Ensembl:ENSMUSP00000141345, GN ECO:0000313|MGI:MGI:1933158}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000141345, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000141345, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141345, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000141345} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141345}; RG Ensembl; RL Submitted (DEC-2014) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate; CC Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25; CC Evidence={ECO:0000256|ARBA:ARBA00001033, CC ECO:0000256|RuleBase:RU364068}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946, CC ECO:0000256|RuleBase:RU364068}; CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol CC from D-glucose 6-phosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005152, CC ECO:0000256|RuleBase:RU364068}. CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily. CC {ECO:0000256|ARBA:ARBA00009759, ECO:0000256|RuleBase:RU364068}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001297362.1; NM_001310433.1. DR SMR; A0A0A6YW07; -. DR jPOST; A0A0A6YW07; -. DR ProteomicsDB; 351040; -. DR Antibodypedia; 25334; 157 antibodies from 26 providers. DR DNASU; 55980; -. DR Ensembl; ENSMUST00000191670.6; ENSMUSP00000141345.2; ENSMUSG00000027531.17. DR GeneID; 55980; -. DR KEGG; mmu:55980; -. DR CTD; 3612; -. DR MGI; MGI:1933158; Impa1. DR VEuPathDB; HostDB:ENSMUSG00000027531; -. DR GeneTree; ENSGT00940000154634; -. DR HOGENOM; CLU_044118_7_2_1; -. DR OrthoDB; 915621at2759; -. DR UniPathway; UPA00823; UER00788. DR BioGRID-ORCS; 55980; 3 hits in 77 CRISPR screens. DR ChiTaRS; Impa1; mouse. DR Proteomes; UP000000589; Chromosome 3. DR Bgee; ENSMUSG00000027531; Expressed in motor neuron and 255 other tissues. DR ExpressionAtlas; A0A0A6YW07; baseline and differential. DR GO; GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:InterPro. DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro. DR CDD; cd01639; IMPase; 1. DR InterPro; IPR033942; IMPase. DR InterPro; IPR020583; Inositol_monoP_metal-BS. DR InterPro; IPR020552; Inositol_monoPase_Li-sen. DR InterPro; IPR000760; Inositol_monophosphatase-like. DR Pfam; PF00459; Inositol_P; 1. DR PRINTS; PR00377; IMPHPHTASES. DR PRINTS; PR00378; LIIMPHPHTASE. DR PROSITE; PS00629; IMP_1; 1. PE 1: Evidence at protein level; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364068}; KW Lithium {ECO:0000256|ARBA:ARBA00022671}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU364068}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|RuleBase:RU364068}; KW Proteomics identification {ECO:0007829|EPD:A0A0A6YW07, KW ECO:0007829|MaxQB:A0A0A6YW07}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 208 AA; 23649 MW; CC3141F194F77F64 CRC64; MADPWQECMD YAVILARQAG EMIREALKNE MDVMIKSSPA DLVTVTDQKV EKMLMSSIKE KYPCHSFIGE ESVAAGEKTV FTEQPTWVID PIDGTTNFVH RFPFVAVSIG FLVNKEMEFG IVYSCVEDKM YTGRKGKGAF CNGQKLQVSQ QEESGVLEQL LLICALWQRE EQMPIMRWES TAGTWRELAS LSPRQAECSW MSRVDRSI //