ID A0A0A6YW07_MOUSE Unreviewed; 208 AA. AC A0A0A6YW07; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 31-JAN-2018, entry version 24. DE RecName: Full=Inositol-1-monophosphatase {ECO:0000256|RuleBase:RU364068}; DE EC=3.1.3.25 {ECO:0000256|RuleBase:RU364068}; GN Name=Impa1 {ECO:0000313|Ensembl:ENSMUSP00000141345, GN ECO:0000313|MGI:MGI:1933158}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000141345, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000141345, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141345, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000141345} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141345}; RG Ensembl; RL Submitted (DEC-2014) to UniProtKB. CC -!- CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol CC + phosphate. {ECO:0000256|RuleBase:RU364068}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|RuleBase:RU364068}; CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo- CC inositol from D-glucose 6-phosphate: step 2/2. CC {ECO:0000256|RuleBase:RU364068}. CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily. CC {ECO:0000256|RuleBase:RU364068}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000141345}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC123726; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001297362.1; NM_001310433.1. DR UniGene; Mm.183042; -. DR SMR; A0A0A6YW07; -. DR Ensembl; ENSMUST00000191670; ENSMUSP00000141345; ENSMUSG00000027531. DR GeneID; 55980; -. DR KEGG; mmu:55980; -. DR CTD; 3612; -. DR MGI; MGI:1933158; Impa1. DR eggNOG; KOG2951; Eukaryota. DR eggNOG; COG0483; LUCA. DR GeneTree; ENSGT00390000014699; -. DR KO; K01092; -. DR Reactome; R-MMU-1855183; Synthesis of IP2, IP, and Ins in the cytosol. DR UniPathway; UPA00823; UER00788. DR Proteomes; UP000000589; Chromosome 3. DR Bgee; ENSMUSG00000027531; -. DR ExpressionAtlas; A0A0A6YW07; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl. DR GO; GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0031403; F:lithium ion binding; IEA:Ensembl. DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl. DR GO; GO:0030145; F:manganese ion binding; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:Ensembl. DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Ensembl. DR GO; GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:Ensembl. DR CDD; cd01639; IMPase; 1. DR InterPro; IPR033942; IMPase. DR InterPro; IPR020583; Inositol_monoP_metal-BS. DR InterPro; IPR020552; Inositol_monoPase_Li-sen. DR InterPro; IPR000760; Inositol_monophosphatase-like. DR Pfam; PF00459; Inositol_P; 1. DR PRINTS; PR00377; IMPHPHTASES. DR PRINTS; PR00378; LIIMPHPHTASE. DR PROSITE; PS00629; IMP_1; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Hydrolase {ECO:0000256|RuleBase:RU364068}; KW Magnesium {ECO:0000256|RuleBase:RU364068}; KW Metal-binding {ECO:0000256|RuleBase:RU364068}; KW Proteomics identification {ECO:0000213|EPD:A0A0A6YW07, KW ECO:0000213|MaxQB:A0A0A6YW07, ECO:0000213|PeptideAtlas:A0A0A6YW07}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 208 AA; 23649 MW; CC3141F194F77F64 CRC64; MADPWQECMD YAVILARQAG EMIREALKNE MDVMIKSSPA DLVTVTDQKV EKMLMSSIKE KYPCHSFIGE ESVAAGEKTV FTEQPTWVID PIDGTTNFVH RFPFVAVSIG FLVNKEMEFG IVYSCVEDKM YTGRKGKGAF CNGQKLQVSQ QEESGVLEQL LLICALWQRE EQMPIMRWES TAGTWRELAS LSPRQAECSW MSRVDRSI //