ID A0A0A2WM79_THEFI Unreviewed; 321 AA. AC A0A0A2WM79; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 09-DEC-2015, entry version 7. DE RecName: Full=Holliday junction ATP-dependent DNA helicase RuvB {ECO:0000256|HAMAP-Rule:MF_00016}; DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_00016}; GN Name=ruvB {ECO:0000256|HAMAP-Rule:MF_00016}; GN ORFNames=THFILI_03480 {ECO:0000313|EMBL:KGQ20923.1}; OS Thermus filiformis. OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; OC Thermus. OX NCBI_TaxID=276 {ECO:0000313|EMBL:KGQ20923.1}; RN [1] {ECO:0000313|EMBL:KGQ20923.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ATCC 43280 {ECO:0000313|EMBL:KGQ20923.1}; RA Mandelli F., Ramires B.O., Paixao D.A., Camilo C.M., Polikarpov I., RA Couger M.B., Prade R., Riano-Pachon D.M., Squina F.M.; RT "Draft Genome Sequence of the thermophile Thermus filiformis ATCC43280 RT producer of carotenoid-(di)glucoside-branched fatty acids RT (di)esters."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The RuvA-RuvB complex in the presence of ATP renatures CC cruciform structure in supercoiled DNA with palindromic sequence, CC indicating that it may promote strand exchange reactions in CC homologous recombination. RuvAB is a helicase that mediates the CC Holliday junction migration by localized denaturation and CC reannealing. {ECO:0000256|HAMAP-Rule:MF_00016}. CC -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. CC {ECO:0000256|HAMAP-Rule:MF_00016}. CC -!- SUBUNIT: Forms a complex with RuvA. {ECO:0000256|HAMAP- CC Rule:MF_00016}. CC -!- SIMILARITY: Belongs to the RuvB family. {ECO:0000256|HAMAP- CC Rule:MF_00016}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KGQ20923.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JPSL02000037; KGQ20923.1; -; Genomic_DNA. DR EnsemblBacteria; KGQ20923; KGQ20923; THFILI_03480. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0009378; F:four-way junction helicase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-HAMAP. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-HAMAP. DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP. DR Gene3D; 1.10.10.10; -; 1. DR Gene3D; 3.40.50.300; -; 1. DR HAMAP; MF_00016; DNA_helic_RuvB; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR004605; DNA_helicase_Holl-junc_RuvB. DR InterPro; IPR008823; DNA_helicase_Holl-junc_RuvB_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR008824; RuvB_N. DR InterPro; IPR011991; WHTH_DNA-bd_dom. DR Pfam; PF05491; RuvB_C; 1. DR Pfam; PF05496; RuvB_N; 1. DR ProDom; PD005323; DNA_helicase_Holl-junc_RuvB_C; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR00635; ruvB; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00016}; KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00016}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_00016}; KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00016}; KW Helicase {ECO:0000256|HAMAP-Rule:MF_00016, KW ECO:0000313|EMBL:KGQ20923.1}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00016}; KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00016}; KW SOS response {ECO:0000256|HAMAP-Rule:MF_00016}. FT DOMAIN 36 168 AAA. {ECO:0000259|SMART:SM00382}. FT NP_BIND 44 51 ATP. {ECO:0000256|HAMAP-Rule:MF_00016}. SQ SEQUENCE 321 AA; 35849 MW; ED15CF062B47F245 CRC64; MEPALRPKTL DEYVGQERLK KKLRVYLEAA KARKEPLDHL LLVGPPGLGK TTLAHIIAYE LGVKIRVTSG PAIEKPGDLA AILTNSLDEG DVLFIDEIHR LSRQAEEHLY PAMEDFKMDI VIGQGPAART LRLDLPRFTL IGATTRPGLL TSPLRSRFGI VEHLEFYTVE ELAQAIRRDA ALLGLEVEEE AAQEMGRRSR GTMRIAKRLF RRVRDFAEVA GERRITLERT LEALRALGLD ELGLEKRDRE ILETLILRFG GGPVGLVTLA TALAEDPGTL EEVYEPYLIQ LGLLKRTPRG RVATEAAYRH LGFALPMDPL L //