ID A0A0A1EI90_DROME Unreviewed; 2082 AA. AC A0A0A1EI90; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 31-JAN-2018, entry version 28. DE SubName: Full=MIP31562p1 {ECO:0000313|EMBL:AIY29188.1}; DE SubName: Full=Myosin 81F {ECO:0000313|EMBL:ALI30523.1}; DE EC=3.6.1.3 {ECO:0000313|EMBL:ALI30523.1}; GN Name=Myo81F {ECO:0000313|EMBL:ALI30523.1, GN ECO:0000313|FlyBase:FBgn0267431}; GN Synonyms=CG15831 {ECO:0000313|EMBL:ALI30523.1}, CG40155 GN {ECO:0000313|EMBL:ALI30523.1}, CG40204 {ECO:0000313|EMBL:ALI30523.1}, GN CG41281 {ECO:0000313|EMBL:ALI30523.1}, CG41518 GN {ECO:0000313|EMBL:ALI30523.1}, CG41527 {ECO:0000313|EMBL:ALI30523.1}, GN CG42621 {ECO:0000313|EMBL:ALI30523.1}, CG42622 GN {ECO:0000313|EMBL:ALI30523.1}, CG42623 {ECO:0000313|EMBL:ALI30523.1}, GN CG42624 {ECO:0000313|EMBL:ALI30523.1}, CG45784-RA GN {ECO:0000313|EMBL:AIY29188.1}, Dmel\CG45784 GN {ECO:0000313|EMBL:ALI30523.1}; GN ORFNames=CG45784 {ECO:0000313|EMBL:ALI30523.1, GN ECO:0000313|FlyBase:FBgn0267431}, Dmel_CG45784 GN {ECO:0000313|EMBL:ALI30523.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AIY29188.1}; RN [1] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ALI30523.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:ALI30523.1} RP NUCLEOTIDE SEQUENCE. RA Qian G., Yu M.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:ALI30523.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AIY29188.1} RP NUCLEOTIDE SEQUENCE. RA Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., RA Celniker S.; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:ALI30523.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase CC superfamily. Myosin family. {ECO:0000256|PROSITE- CC ProRule:PRU00782}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT150454; AIY29188.1; -; mRNA. DR EMBL; AE014297; ALI30523.1; -; Genomic_DNA. DR RefSeq; NP_001303492.1; NM_001316563.1. DR SMR; A0A0A1EI90; -. DR STRING; 7227.FBpp0291459; -. DR PaxDb; A0A0A1EI90; -. DR GeneID; 26067052; -. DR KEGG; dme:Dmel_CG45784; -. DR CTD; 26067052; -. DR FlyBase; FBgn0267431; Myo81F. DR eggNOG; KOG4229; Eukaryota. DR eggNOG; COG5022; LUCA. DR Proteomes; UP000000803; Chromosome 3R. DR ExpressionAtlas; A0A0A1EI90; differential. DR GO; GO:0016459; C:myosin complex; ISS:FlyBase. DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0042623; F:ATPase activity, coupled; ISS:FlyBase. DR GO; GO:0003774; F:motor activity; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd14473; FERM_B-lobe; 2. DR Gene3D; 1.20.80.10; -; 2. DR Gene3D; 2.30.29.30; -; 2. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR000048; IQ_motif_EF-hand-BS. DR InterPro; IPR001609; Myosin_head_motor_dom. DR InterPro; IPR000857; MyTH4_dom. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR000159; RA_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR Pfam; PF00373; FERM_M; 2. DR Pfam; PF00063; Myosin_head; 1. DR Pfam; PF00784; MyTH4; 2. DR Pfam; PF00788; RA; 2. DR PRINTS; PR00193; MYOSINHEAVY. DR SMART; SM00295; B41; 2. DR SMART; SM00015; IQ; 3. DR SMART; SM00242; MYSc; 1. DR SMART; SM00139; MyTH4; 2. DR SMART; SM00314; RA; 1. DR SUPFAM; SSF47031; SSF47031; 2. DR SUPFAM; SSF50729; SSF50729; 2. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF54236; SSF54236; 2. DR PROSITE; PS50057; FERM_3; 2. DR PROSITE; PS50096; IQ; 2. DR PROSITE; PS51456; MYOSIN_MOTOR; 1. DR PROSITE; PS51016; MYTH4; 2. DR PROSITE; PS50200; RA; 1. PE 2: Evidence at transcript level; KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782}; KW ATP-binding {ECO:0000256|SAAS:SAAS00941533}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Hydrolase {ECO:0000313|EMBL:ALI30523.1}; KW Motor protein {ECO:0000256|SAAS:SAAS00941000}; KW Myosin {ECO:0000256|PROSITE-ProRule:PRU00782, KW ECO:0000256|SAAS:SAAS00941546}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00941057}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 8 685 Myosin motor. {ECO:0000259|PROSITE: FT PS51456}. FT DOMAIN 1046 1196 MyTH4. {ECO:0000259|PROSITE:PS51016}. FT DOMAIN 1201 1525 FERM. {ECO:0000259|PROSITE:PS50057}. FT DOMAIN 1613 1773 MyTH4. {ECO:0000259|PROSITE:PS51016}. FT DOMAIN 1776 1879 Ras-associating. {ECO:0000259|PROSITE: FT PS50200}. FT DOMAIN 1778 2082 FERM. {ECO:0000259|PROSITE:PS50057}. FT NP_BIND 101 108 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00782}. FT REGION 566 588 Actin-binding. {ECO:0000256|PROSITE- FT ProRule:PRU00782}. SQ SEQUENCE 2082 AA; 240761 MW; 24B725AC35BDA78E CRC64; MMSIGRRVGF ADMTEMSEID EIGINQNLNV RYNSDIIYTY TGSILLAVNP YKTINIFNKQ TISEYHTCKL GDLSPHVFAV AEAAYTSIVD DNINQACVIS GESGAGKTES TKFILQYLCT ITSNVSSWVQ QQILEANTIL EAFGNAKTTR NDNSSRFGKF MQVCFDDNNC IKGCVILDYL LEQSRITFQS EGERNYHIMY QLVAQGQKNI GIANTFHLRP AEFYKYLNTS NSEKINMNLE SKKFDAVTMA FTVLQIPQFV IDGVFKVISS ILWLGNIEFI DVDGEVTDLT RSDQEAISII SMLLGLSRCD FKKVLLIRQI NVRGNITEIP LKIKEALENR HALAKALYSK MFTWLVSKIN NCTNPGQDDA KFLGVLDIFG FENFSHNSFE QLCINYTNEK LHKFFNHYVF ALEQSIYEHE GIYFNHVEFT DNTPCLEILE KPPRCVFKLL TEQCHMPQGS DLAFLSNMHT EFESHPNYIK GSDRRHWETE FGIKHYAGLV IYAVGGFVEK NRDVQQDVMF EYMSYSKDVF IKDLSTYQDI QFINSSYPRG SSKSKCTVSD NFRNQLQSLI DVLQNTKPWY VRCIKPNLQK RPNNYNSSLV LDQLKYLGVV DIIRIRREGF PIHLSHKDFI VRYKCLIKNK SFEYPQKYLT NILEKNGMPT TEWQIGKSKI FLRNAAYELL ETNRKDTLYK NAVIIQKNWK KYYIQKSFLR NKQAVLRIQH AYRGWRLRIR FMRMRRSAIV IQSRLRGVFA REVAAALREM KRVDEELKKR DGIYEQLTSI TTKTLADCER SIQEELSVLA HISDNIRASA KPLSDKNDSD SNTARSSIKQ NTVNLDNMFD FLCESKGAFE NALIKEINDN WNNLVKNLDE EIGLCIHTED SFDSQKTGKL FTTKTVRTLP EPTVPPPPPP VSISANLNSE PIYEAINLYK LTTTKEIKKE KYMLLDYKSI KDNSKKPSTS SVFVKYQIDE RENRRKQRVE KKIHELTLID IHKDIHIDNS FYNILEFAEN YFNTHDLSSD CNFISTPTQK GKSSDKTAKH EMTMFSKSDK IPTSHIHMYD PENVVLSCSM FRELCKYMRG ELNAERELQI IQYIVGLGIE REELRDEIFI QCIRQSRNNP NIDWTDRIWI ILCLSIVAFQ PSKLLFRYFV SFIKKSMIEL DGKLRQYSQW CFDNCKSTKV STRMYPPSSV EVAAMRRLGT IVCRFFFLDA RTKAIDVHPT DTAGDAVQKL AEKLNLTTTD GWAIYQNRPD GEEHIKSYDY LYDVISSWEM KQATYAGTKK TTNGSSSGEN QFVFKKRLFK STHELSQDPV EVSMLYSQAV HSVVKKDEFP VSEKVALQLA GLQAQVALGD PSNQPKPEYY SDINSFLPIR ISKTREQQFW IPILAQAHRQ YGSSRNALTA KVLYLSCVMQ YPLYGTTMFK VNYKGYWNLA SNIILGIHYD GIMFINPEDK SVVFQFKYVD IESILLDPSD SFITISLNRS AQLLKTSLYG SSLIESQKCF VFETPQKNDI GSLIISYYPA LSNWILNNLE CSKKYKGTTK EDRLRLYQNV VLCRRHLVDM NIVKKPHDFG GFLRNTLRRL SKHRLEKLRS EVGSNTQEHG ETYKGFSHTF WAFSKQQIPF CISTISDQEE ALMIQVFDSI LTYSGLGSSG ESISRAEDEH IRIIQSIMDK CMKKESLLNE LYLQLIKQTT DHPDANSRVN LKNWALLSVL CSVILPSMKA VRKYLIAHLK RCSSDFLSEE GKYARYAENC FFRTQGTRRR QWTPSREEIL CTTNRRPCYS KFYFMDGQYY SIEFQPSSTA NDVLEIIKKK IGLLDNAKGY SIYEVIGNSE RSLSSEEKVC DVMAKWEKYQ ITSQQGFQKN TTLISQQNQY MFLFKKHLFF DNYINLEDIV EKELLYHQIL HNLRSERYPI TEMEAIMLTA LQSQLERGDC CESITDYRAV ASHCLPPRFV PNIPHEAVAM HHQSLRGMLP IEAKKAFLNL IKSWPLHRAT IFDVMQSFTT NWPRTLWLAI DQKGIHLLEH RSRNVLCTYG YDSIISFSPN LNSLMIFTGT EKKQSKVILT TPQAYQITTL IREYSEAAKD MK //