ID A0A0A0RKV3_SIV Unreviewed; 887 AA. AC A0A0A0RKV3; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 19-JAN-2022, entry version 42. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095}; DE Short=SU {ECO:0000256|RuleBase:RU363095}; DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095}; DE Short=gp120 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095}; DE Short=TM {ECO:0000256|RuleBase:RU363095}; GN Name=env {ECO:0000313|EMBL:AIW01352.1}; OS Simian immunodeficiency virus (SIV). OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AIW01352.1}; OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] {ECO:0000313|EMBL:AIW01352.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SIVsmE660.TU.SGA7 {ECO:0000313|EMBL:AIW01352.1}; RX PubMed=25360552; RA Gambhira R., Keele B.F., Schell J.B., Hunter M.J., Dufour J.P., RA Montefiori D.C., Tang H., Rose J.K., Rose N., Marx P.A.; RT "Transmitted/Founder Simian Immunodeficiency Virus Envelope Sequences in RT Vesicular Stomatitis and Semliki Forest Virus Vector Immunized Rhesus RT Macaques."; RL PLoS ONE 9:E109678-E109678(2014). CC -!- SUBUNIT: The mature envelope protein (Env) consists of a homotrimer of CC non-covalently associated gp120-gp41 heterodimers. The resulting CC complex protrudes from the virus surface as a spike. CC {ECO:0000256|RuleBase:RU363095}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004578}. Membrane CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004170}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004563}. CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is present in CC many retroviral envelope proteins. Synthetic peptides derived from this CC relatively conserved sequence inhibit immune function in vitro and in CC vivo. {ECO:0000256|RuleBase:RU363095}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KM496911; AIW01352.1; -; Genomic_RNA. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; IEA:UniProt. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR CDD; cd09909; HIV-1-like_HR1-HR2; 1. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR036377; Gp120_core_sf. DR InterPro; IPR000328; GP41-like. DR InterPro; IPR000777; HIV1_Gp120. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 1. PE 4: Predicted; KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|RuleBase:RU363095}; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685, KW ECO:0000256|RuleBase:RU363095}; Coiled coil {ECO:0000256|SAM:Coils}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|RuleBase:RU363095}; KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511, KW ECO:0000256|RuleBase:RU363095}; KW Host endosome {ECO:0000256|ARBA:ARBA00023046, KW ECO:0000256|RuleBase:RU363095}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870, KW ECO:0000256|RuleBase:RU363095}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581, KW ECO:0000256|RuleBase:RU363095}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363095}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU363095}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU363095}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095}; KW Viral envelope protein {ECO:0000256|RuleBase:RU363095, KW ECO:0000313|EMBL:AIW01352.1}; KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095}; KW Virion {ECO:0000256|RuleBase:RU363095}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095}. FT TRANSMEM 698..719 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363095" FT DOMAIN 24..533 FT /note="GP120" FT /evidence="ECO:0000259|Pfam:PF00516" FT DOMAIN 551..746 FT /note="GP41" FT /evidence="ECO:0000259|Pfam:PF00517" FT REGION 745..766 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 645..672 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 750..764 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 887 AA; 102212 MW; FB71284E0D716AA3 CRC64; MGCLGNQLLI ALLLVSALEI YCVQYVTVFY GVPAWKNATI PLFCTTRNRD TWGTTQCLPD NDDYSELAIS ITEAFDAWNN TVTEQAIEDV WNLFETSIKP CVKLTPLCIA MRCNKTETDR WGLTRNAGTT TTTTTTTTAA TPSVAENVIN ESNPCIKNNS CAGLEQEPMI GCKFNMTGLK RDKRIEYNET WYSRDLICEQ SANESESKCY MHHCNTSVIQ ESCDKHYWDA IRFRYCAPPG YALLRCNDSN YSGFAPNCSK VVVSSCTRMM ETQTSTWFGF NGTRAENRTY IYWHGKSNRT IISLNKYYNL TMRCRRPGNK TVLPVTIMSG LVFHSQPINE RPKQAWCWFG GSWKEAIQEV KETLVKHPRY TGTNDTKKIN LTAPAGGDPE VTFMWTNCRG EFLYCKMNWF LNWVEDRDQK SSRWRQQNTR ERQKKNYVPC HIRQIINTWH KVGKNVYLLP REGDLTCNST VTSLIAEIDW TNNNETNITM SAEVAELYRL ELGDYKLVEI TPIGLAPTSV RRYTTTGASR NKRGVFVLGF LGFLATAGSA MGAASLTLSA QSRTLLAGIV QQQQQLLDVV KRQQELLRLT VWGTKNLQTR VTAIEKYLKD QAQLNSWGCA FRQVCHTTVP WPNETLVPNW SNMTWQEWER QVDFLEANIT QLLEEAQIQQ EKNMYELQKL NSWDIFGNWF DLTSWIRYIQ YGVLIVLGVV GLRIVIYVVQ MLARLRQGYR PVFSSPPAYV QQIPIHKGQE PPTKEGEEGE GGDRGGNRSW PWQIEYIHFL IRQLIRLLTW LFSSCRDWLL RIYQVLQPVL QSLSTTSQRV REVIRIGIAY LQYGWRYFQE AVQAWWKFAR ETLASAWRDI WETLGRVGRG ILAIPRRVRQ GLELTLL //