ID A0A0A0RKV3_SIV Unreviewed; 887 AA. AC A0A0A0RKV3; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 18-JUL-2018, entry version 29. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095}; DE Short=SU {ECO:0000256|RuleBase:RU363095}; DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095}; DE Short=gp120 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095}; DE Short=TM {ECO:0000256|RuleBase:RU363095}; GN Name=env {ECO:0000313|EMBL:AIW01352.1}; OS Simian immunodeficiency virus (SIV). OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AIW01352.1}; OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] {ECO:0000313|EMBL:AIW01352.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SIVsmE660.TU.SGA7 {ECO:0000313|EMBL:AIW01352.1}; RX PubMed=25360552; RA Gambhira R., Keele B.F., Schell J.B., Hunter M.J., Dufour J.P., RA Montefiori D.C., Tang H., Rose J.K., Rose N., Marx P.A.; RT "Transmitted/Founder Simian Immunodeficiency Virus Envelope Sequences RT in Vesicular Stomatitis and Semliki Forest Virus Vector Immunized RT Rhesus Macaques."; RL PLoS ONE 9:E109678-E109678(2014). CC -!- SUBUNIT: The mature envelope protein (Env) consists of a CC homotrimer of non-covalently associated gp120-gp41 heterodimers. CC The resulting complex protrudes from the virus surface as a spike. CC {ECO:0000256|RuleBase:RU363095}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS01060237}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS01060237}. Host cell membrane CC {ECO:0000256|SAAS:SAAS01060091}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS01060091}. Host endosome membrane CC {ECO:0000256|SAAS:SAAS01060316}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS01060316}. Virion membrane CC {ECO:0000256|SAAS:SAAS00796993}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00796993}. CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is CC present in many retroviral envelope proteins. Synthetic peptides CC derived from this relatively conserved sequence inhibit immune CC function in vitro and in vivo. {ECO:0000256|RuleBase:RU363095}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KM496911; AIW01352.1; -; Genomic_RNA. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR CDD; cd09909; HIV-1-like_HR1-HR2; 1. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR036377; Gp120_core_sf. DR InterPro; IPR000328; GP41-like. DR InterPro; IPR000777; HIV1_Gp120. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 3. PE 4: Predicted; KW Apoptosis {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060203}; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU363095}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Disulfide bond {ECO:0000256|SAAS:SAAS01050261}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS01050351}; KW Host cell membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060118}; KW Host endosome {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060155}; KW Host membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060308}; KW Host-virus interaction {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797036}; KW Membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797370}; KW Transmembrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797262}; KW Transmembrane helix {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797734}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797747}; KW Viral envelope protein {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797156, ECO:0000313|EMBL:AIW01352.1}; KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01050355}; KW Virion {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00796948}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797206}. FT TRANSMEM 698 719 Helical. {ECO:0000256|RuleBase:RU363095}. FT DOMAIN 24 533 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 551 744 GP41. {ECO:0000259|Pfam:PF00517}. FT COILED 645 672 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 887 AA; 102212 MW; FB71284E0D716AA3 CRC64; MGCLGNQLLI ALLLVSALEI YCVQYVTVFY GVPAWKNATI PLFCTTRNRD TWGTTQCLPD NDDYSELAIS ITEAFDAWNN TVTEQAIEDV WNLFETSIKP CVKLTPLCIA MRCNKTETDR WGLTRNAGTT TTTTTTTTAA TPSVAENVIN ESNPCIKNNS CAGLEQEPMI GCKFNMTGLK RDKRIEYNET WYSRDLICEQ SANESESKCY MHHCNTSVIQ ESCDKHYWDA IRFRYCAPPG YALLRCNDSN YSGFAPNCSK VVVSSCTRMM ETQTSTWFGF NGTRAENRTY IYWHGKSNRT IISLNKYYNL TMRCRRPGNK TVLPVTIMSG LVFHSQPINE RPKQAWCWFG GSWKEAIQEV KETLVKHPRY TGTNDTKKIN LTAPAGGDPE VTFMWTNCRG EFLYCKMNWF LNWVEDRDQK SSRWRQQNTR ERQKKNYVPC HIRQIINTWH KVGKNVYLLP REGDLTCNST VTSLIAEIDW TNNNETNITM SAEVAELYRL ELGDYKLVEI TPIGLAPTSV RRYTTTGASR NKRGVFVLGF LGFLATAGSA MGAASLTLSA QSRTLLAGIV QQQQQLLDVV KRQQELLRLT VWGTKNLQTR VTAIEKYLKD QAQLNSWGCA FRQVCHTTVP WPNETLVPNW SNMTWQEWER QVDFLEANIT QLLEEAQIQQ EKNMYELQKL NSWDIFGNWF DLTSWIRYIQ YGVLIVLGVV GLRIVIYVVQ MLARLRQGYR PVFSSPPAYV QQIPIHKGQE PPTKEGEEGE GGDRGGNRSW PWQIEYIHFL IRQLIRLLTW LFSSCRDWLL RIYQVLQPVL QSLSTTSQRV REVIRIGIAY LQYGWRYFQE AVQAWWKFAR ETLASAWRDI WETLGRVGRG ILAIPRRVRQ GLELTLL //