ID A0A0A0L3W8_CUCSA Unreviewed; 336 AA. AC A0A0A0L3W8; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 29-MAY-2024, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KGN56645.1}; GN ORFNames=Csa_3G127080 {ECO:0000313|EMBL:KGN56645.1}; OS Cucumis sativus (Cucumber). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis. OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN56645.1, ECO:0000313|Proteomes:UP000029981}; RN [1] {ECO:0000313|EMBL:KGN56645.1, ECO:0000313|Proteomes:UP000029981} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981}; RX PubMed=19881527; DOI=10.1038/ng.475; RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X., RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G., RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z., RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B., RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B., RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y., RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H., RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G., RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X., RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G., RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H., RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.; RT "The genome of the cucumber, Cucumis sativus L."; RL Nat. Genet. 41:1275-1281(2009). CC -!- CATALYTIC ACTIVITY: CC Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5- CC carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526, CC ChEBI:CHEBI:58639; EC=4.1.1.97; CC Evidence={ECO:0000256|ARBA:ARBA00001163}; CC -!- CATALYTIC ACTIVITY: CC Reaction=5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5- CC dihydro-1H-imidazole-5-carboxylate + H(+); Xref=Rhea:RHEA:23736, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18072, CC ChEBI:CHEBI:58639; EC=3.5.2.17; CC Evidence={ECO:0000256|ARBA:ARBA00001043}; CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from CC urate: step 3/3. {ECO:0000256|ARBA:ARBA00004754}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CM002924; KGN56645.1; -; Genomic_DNA. DR RefSeq; XP_004133944.1; XM_004133896.2. DR AlphaFoldDB; A0A0A0L3W8; -. DR STRING; 3659.A0A0A0L3W8; -. DR EnsemblPlants; KGN56645; KGN56645; Csa_3G127080. DR GeneID; 101221191; -. DR Gramene; KGN56645; KGN56645; Csa_3G127080. DR KEGG; csv:101221191; -. DR eggNOG; KOG3006; Eukaryota. DR OMA; EPEGHYH; -. DR OrthoDB; 324942at2759; -. DR Proteomes; UP000029981; Chromosome 3. DR GO; GO:0005777; C:peroxisome; IEA:TreeGrafter. DR GO; GO:0051997; F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity; IEA:TreeGrafter. DR GO; GO:0033971; F:hydroxyisourate hydrolase activity; IEA:UniProtKB-EC. DR GO; GO:0006144; P:purine nucleobase metabolic process; IBA:GO_Central. DR GO; GO:0019628; P:urate catabolic process; IEA:TreeGrafter. DR CDD; cd05822; TLP_HIUase; 1. DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1. DR Gene3D; 2.60.40.180; Transthyretin/hydroxyisourate hydrolase domain; 1. DR InterPro; IPR014306; Hydroxyisourate_hydrolase. DR InterPro; IPR018020; OHCU_decarboxylase. DR InterPro; IPR036778; OHCU_decarboxylase_sf. DR InterPro; IPR023418; Thyroxine_BS. DR InterPro; IPR023416; Transthyretin/HIU_hydrolase_d. DR InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf. DR InterPro; IPR023419; Transthyretin_CS. DR NCBIfam; TIGR02962; hdxy_isourate; 1. DR PANTHER; PTHR43466; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1. DR PANTHER; PTHR43466:SF1; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1. DR Pfam; PF09349; OHCU_decarbox; 1. DR Pfam; PF00576; Transthyretin; 1. DR SUPFAM; SSF49472; Transthyretin (synonym: prealbumin); 1. DR SUPFAM; SSF158694; UraD-Like; 1. DR PROSITE; PS00768; TRANSTHYRETIN_1; 1. DR PROSITE; PS00769; TRANSTHYRETIN_2; 1. PE 4: Predicted; KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Lyase {ECO:0000256|ARBA:ARBA00023239}; KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631}; KW Reference proteome {ECO:0000313|Proteomes:UP000029981}. FT DOMAIN 8..158 FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline FT decarboxylase" FT /evidence="ECO:0000259|Pfam:PF09349" FT DOMAIN 217..335 FT /note="Transthyretin/hydroxyisourate hydrolase" FT /evidence="ECO:0000259|Pfam:PF00576" SQ SEQUENCE 336 AA; 37110 MW; 4CC88EF861F96FD4 CRC64; MASNYDFVEE EFQACCGSSK FAKEMVSASP FFSLEQAIAA ARHIWFNQVD VSGWLEAFSA HPRIGGQVSK SSNQTSAQWS KGEQSTAMAT ATGSSLQELA EWNIQYQQKF GFVFLICASG RSTSEILAEL KKRYPSRPIV EFEIAAQEQM KITELRLAKL FSTKQNTSST RESHPPPDFA RKVEEDRVNV IGGHLGATSE ASTGKTSQIL TRTRPPITTH VLDVARGSPA TGIDVRLERW IGTQPRPLFG EADVGGWALE GTSATDKDGR SGQLLSMVEA INPGIYRISF NTGKYFPAGF FPYVSIVFEI RESQKLEHFH VPLLLSPFSF STYRGS //