ID A0A099YT33_TINGU Unreviewed; 852 AA. AC A0A099YT33; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 12-AUG-2020, entry version 24. DE RecName: Full=Alpha-actinin cytoskeletal isoform {ECO:0000256|ARBA:ARBA00015114}; DE AltName: Full=Alpha-actinin-1 {ECO:0000256|ARBA:ARBA00018384}; DE AltName: Full=F-actin cross-linking protein {ECO:0000256|ARBA:ARBA00018289}; DE AltName: Full=Non-muscle alpha-actinin-1 {ECO:0000256|ARBA:ARBA00019895}; DE Flags: Fragment; GN ORFNames=N309_08045 {ECO:0000313|EMBL:KGL73434.1}; OS Tinamus guttatus (White-throated tinamou). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus. OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL73434.1, ECO:0000313|Proteomes:UP000053641}; RN [1] {ECO:0000313|EMBL:KGL73434.1, ECO:0000313|Proteomes:UP000053641} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL73434.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}. CC Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cell projection, ruffle CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, myofibril, sarcomere, Z CC line {ECO:0000256|ARBA:ARBA00004216}. Membrane CC {ECO:0000256|ARBA:ARBA00004370}. CC -!- SIMILARITY: Belongs to the alpha-actinin family. CC {ECO:0000256|ARBA:ARBA00010255}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KL885931; KGL73434.1; -; Genomic_DNA. DR Proteomes; UP000053641; Unassembled WGS sequence. DR GO; GO:0005923; C:bicellular tight junction; ISS:AgBase. DR GO; GO:0031252; C:cell leading edge; ISS:AgBase. DR GO; GO:0097433; C:dense body; ISS:AgBase. DR GO; GO:0005925; C:focal adhesion; ISS:AgBase. DR GO; GO:0090637; C:inner dense plaque of desmosome; ISS:AgBase. DR GO; GO:0030027; C:lamellipodium; ISS:AgBase. DR GO; GO:0016328; C:lateral plasma membrane; ISS:AgBase. DR GO; GO:0090636; C:outer dense plaque of desmosome; ISS:AgBase. DR GO; GO:0042383; C:sarcolemma; ISS:AgBase. DR GO; GO:0030486; C:smooth muscle dense body; ISS:AgBase. DR GO; GO:0001725; C:stress fiber; ISS:AgBase. DR GO; GO:1990357; C:terminal web; ISS:AgBase. DR GO; GO:0005915; C:zonula adherens; ISS:AgBase. DR GO; GO:0051015; F:actin filament binding; IEA:InterPro. DR GO; GO:0051393; F:alpha-actinin binding; ISS:AgBase. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0042803; F:protein homodimerization activity; ISS:AgBase. DR GO; GO:0017166; F:vinculin binding; ISS:AgBase. DR GO; GO:0051764; P:actin crosslink formation; IEA:InterPro. DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro. DR GO; GO:0045214; P:sarcomere organization; ISS:AgBase. DR GO; GO:0048741; P:skeletal muscle fiber development; ISS:AgBase. DR CDD; cd00014; CH; 2. DR CDD; cd00051; EFh; 1. DR Gene3D; 1.10.418.10; -; 2. DR InterPro; IPR001589; Actinin_actin-bd_CS. DR InterPro; IPR026921; Alpha-actinin_1. DR InterPro; IPR001715; CH-domain. DR InterPro; IPR036872; CH_dom_sf. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR014837; EF-hand_Ca_insen. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR018159; Spectrin/alpha-actinin. DR InterPro; IPR002017; Spectrin_repeat. DR PANTHER; PTHR11915:SF434; PTHR11915:SF434; 1. DR Pfam; PF00307; CH; 2. DR Pfam; PF08726; EFhand_Ca_insen; 1. DR Pfam; PF00435; Spectrin; 4. DR SMART; SM00033; CH; 2. DR SMART; SM00054; EFh; 2. DR SMART; SM00150; SPEC; 3. DR SUPFAM; SSF47473; SSF47473; 1. DR SUPFAM; SSF47576; SSF47576; 1. DR PROSITE; PS00020; ACTININ_2; 1. DR PROSITE; PS50021; CH; 2. DR PROSITE; PS50222; EF_HAND_2; 2. PE 3: Inferred from homology; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Reference proteome {ECO:0000313|Proteomes:UP000053641}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 1..100 FT /note="Calponin-homology (CH)" FT /evidence="ECO:0000259|PROSITE:PS50021" FT DOMAIN 109..215 FT /note="Calponin-homology (CH)" FT /evidence="ECO:0000259|PROSITE:PS50021" FT DOMAIN 711..746 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 747..782 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT COILED 230..257 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 395..429 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:KGL73434.1" FT NON_TER 852 FT /evidence="ECO:0000313|EMBL:KGL73434.1" SQ SEQUENCE 852 AA; 98405 MW; 47F83CF6625E765C CRC64; TFTAWCNSHL RKAGTQIENI EEDFRDGLKL MLLLEVISGE RLAKPERGKM RVHKISNVNK ALDFIASKGV KLVSIGAEEI VDGNVKMTLG MIWTIILRFA IQDISVEETS AKEGLLLWCQ RKTAPYKNVN IQNFHISWKD GLGFCALIHR HRPELIDYGK LRKDDPLTNL NTAFDVAEKY LDIPKMLDAE DIVGTLRPDE KAVMTYVSCY YHAFSGAQKA ETAANRICKV LAVNQENEQL MEDYEKLASD LLEWIRRTIP WLENRVPENT MQAMQQKLED FRDYRRLHKP PKVQEKCQLE INFNTLQTKL RLSNRPAFMP SEGKMVSDIN NAWGGLEQAE KGYEEWLLNE IRRLERLDHL AEKFRQKASI HESWTDGKEA MLQQKDYEIA TLSEIKALLK KHEAFESDLA AHQDRVEQIA AIAQELNELD YYDSPSVNAR CQKICDQWDN LGALTQKRRE ALERTEKLLE TIDQLYLEYA KRAAPFNNWM EGAMEDLQDT FIVHTIEEIQ GLTTAHEQFK ATLPDADKER QAILGIHNEV SKIVQTYHVN MAGTNPYTTI TPQEINGKWE HVRQLVPRRD QALMEEHARQ QQNERLRKQF GAQANVIGPW IQTKMEEIGR ISIEMHGTLE DQLNHLRQYE KSIVNYKPKI DQLEGDHQQI QEALIFDNKH TNYTMEHIRV GWEQLLTTIA RTINEVENQI LTRDAKGISQ EQMNEFRASF NHFDRKKTGM MDCEDFRACL ISMGYNMGEA EFARIMSIVD PNRMGVVTFQ AFIDFMSRET ADTDTADQVM ASFKILAGDK NYITVDELRR ELPPDQAEYC IARMAPYHGH DAVPGALDYM SFSTALYGES DL //