ID   A0A096XNG5_9BETC        Unreviewed;       426 AA.
AC   A0A096XNG5;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   01-APR-2015, entry version 2.
DE   SubName: Full=Hemagglutinin-esterase {ECO:0000313|EMBL:AID16648.1};
GN   Name=HE {ECO:0000256|RuleBase:RU361278};
OS   Longquan Rl rat coronavirus.
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Nidovirales;
OC   Coronaviridae; Coronavirinae; Betacoronavirus;
OC   unclassified Betacoronavirus.
OX   NCBI_TaxID=1508223 {ECO:0000313|EMBL:AID16648.1};
RN   [1] {ECO:0000313|EMBL:AID16648.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Longquan-189 {ECO:0000313|EMBL:AID16648.1};
RA   Wang W., Lin X.-D., Zhou R.-H., Guo W.-P., Zhang Y.-Z.;
RT   "Discovery and phylogeny of coronaviruses harbored by birds and
RT   mammals.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May serve as a secondary viral attachment protein for
CC       initiating infection, the spike protein being the major one.
CC       Structural protein that makes short spikes at the surface of the
CC       virus. Contains receptor binding and receptor-destroying
CC       activities. Seems to be a 'luxury' protein that is not absolutely
CC       necessary for virus infection in culture.
CC       {ECO:0000256|RuleBase:RU361278}.
CC   -!- CATALYTIC ACTIVITY: N-acetyl-O-acetylneuraminate + H(2)O = N-
CC       acetylneuraminate + acetate. {ECO:0000256|RuleBase:RU361278}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane
CC       {ECO:0000256|RuleBase:RU361278}; Single-pass type I membrane
CC       protein {ECO:0000256|RuleBase:RU361278}. Host cell membrane
CC       {ECO:0000256|RuleBase:RU361278}; Single-pass type I membrane
CC       protein {ECO:0000256|RuleBase:RU361278}. Note=In infected cells
CC       becomes incorporated into the envelope of virions during virus
CC       assembly at the endoplasmic reticulum and cis Golgi. However, some
CC       may escape incorporation into virions and subsequently migrate to
CC       the cell surface. {ECO:0000256|RuleBase:RU361278}.
CC   -!- SIMILARITY: Belongs to the influenza type C/coronaviruses
CC       hemagglutinin-esterase family. {ECO:0000256|RuleBase:RU361278}.
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DR   EMBL; KF294370; AID16648.1; -; Genomic_RNA.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR   InterPro; IPR008980; Capsid_hemagglutn.
DR   InterPro; IPR007142; Hemagglutn-estrase_core.
DR   InterPro; IPR003860; Hemagglutn-estrase_hemagglutn.
DR   InterPro; IPR013830; SGNH_hydro.
DR   Pfam; PF03996; Hema_esterase; 1.
DR   Pfam; PF02710; Hema_HEFG; 1.
DR   SUPFAM; SSF49818; SSF49818; 1.
DR   SUPFAM; SSF52266; SSF52266; 2.
PE   3: Inferred from homology;
KW   Hemagglutinin {ECO:0000256|RuleBase:RU361278};
KW   Host cell membrane {ECO:0000256|RuleBase:RU361278};
KW   Host membrane {ECO:0000256|RuleBase:RU361278};
KW   Hydrolase {ECO:0000256|RuleBase:RU361278};
KW   Membrane {ECO:0000256|RuleBase:RU361278};
KW   Viral envelope protein {ECO:0000256|RuleBase:RU361278};
KW   Virion {ECO:0000256|RuleBase:RU361278}.
SQ   SEQUENCE   426 AA;  47667 MW;  A36DEC6318C2E119 CRC64;
     MCKNLITLYY LDNMWKLLLL CSVCYGFNDP LNVVSHFNDD WFLFGDSRSD CNHLPNNRSY
     MDLDPSLCDS GKISSKAGNS IFRSFHFTDF YNYTGEGNQI IFYEGVNFTP HHAFKCTASG
     SNVVWIQNKG SFYHKLYNSM SHYRTLTIVN VPYSYGGQAK PTTMCKSGSL TLNNPAFIAK
     EVGVNDYYYK SEANFTLTGC DEYIVPLCIF NGKFLSTGNY YDDSQYYYNM DTGVIYGFNS
     TSSASVGLDL ECKYLNLKSG SYKAISNELL LTIPIKAICL NKAKAFVPVQ VVDSRWNSGR
     VSDNKTAEAC KLPFCYFRNS TGNYLGRYDI NHGDAGFTSI LSGLLYNVPC IAFQGAFYYD
     NVTTVWPSSG SGHCPTASNI IVNIPVCAYD PLPIILLGIL LGIAVLIIVF LMFYFLVDNG
     VRLHEA
//