ID A0A096MJX7_RAT Unreviewed; 457 AA. AC A0A096MJX7; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 29-MAY-2024, entry version 12. DE RecName: Full=Platelet glycoprotein 4 {ECO:0000256|ARBA:ARBA00020772}; DE AltName: Full=Glycoprotein IIIb {ECO:0000256|ARBA:ARBA00032780}; DE AltName: Full=PAS IV {ECO:0000256|ARBA:ARBA00031821}; DE AltName: Full=PAS-4 {ECO:0000256|ARBA:ARBA00032188}; DE AltName: Full=Platelet glycoprotein IV {ECO:0000256|ARBA:ARBA00029966}; GN Name=Cd36 {ECO:0000313|RGD:2301}; GN Synonyms=Cd36-ps1 {ECO:0000313|Ensembl:ENSRNOP00000068300.2, GN ECO:0000313|RGD:41249586}, Cd36l1 {ECO:0000313|RGD:1565355}, GN RGD1565355 {ECO:0000313|RGD:1565355}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000068300.2, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000068300.2, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000068300.2, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000068300.2} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000068300.2}; RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); CC Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; CC Evidence={ECO:0000256|ARBA:ARBA00000626}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33656; CC Evidence={ECO:0000256|ARBA:ARBA00000626}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)- CC octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; CC Evidence={ECO:0000256|ARBA:ARBA00000542}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45265; CC Evidence={ECO:0000256|ARBA:ARBA00000542}; CC -!- CATALYTIC ACTIVITY: CC Reaction=butanoate(out) = butanoate(in); Xref=Rhea:RHEA:45248, CC ChEBI:CHEBI:17968; Evidence={ECO:0000256|ARBA:ARBA00001892}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45249; CC Evidence={ECO:0000256|ARBA:ARBA00001892}; CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, CC ChEBI:CHEBI:7896; Evidence={ECO:0000256|ARBA:ARBA00000934}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45257; CC Evidence={ECO:0000256|ARBA:ARBA00000934}; CC -!- CATALYTIC ACTIVITY: CC Reaction=tetracosanoate(out) = tetracosanoate(in); CC Xref=Rhea:RHEA:45260, ChEBI:CHEBI:31014; CC Evidence={ECO:0000256|ARBA:ARBA00023949}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45261; CC Evidence={ECO:0000256|ARBA:ARBA00023949}; CC -!- CATALYTIC ACTIVITY: CC Reaction=tetradecanoate(out) = tetradecanoate(in); CC Xref=Rhea:RHEA:45252, ChEBI:CHEBI:30807; CC Evidence={ECO:0000256|ARBA:ARBA00000996}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45253; CC Evidence={ECO:0000256|ARBA:ARBA00000996}; CC -!- SUBCELLULAR LOCATION: Apical cell membrane CC {ECO:0000256|ARBA:ARBA00004221}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004236}. Golgi apparatus CC {ECO:0000256|ARBA:ARBA00004555}. Membrane raft CC {ECO:0000256|ARBA:ARBA00004285}. CC -!- SIMILARITY: Belongs to the CD36 family. CC {ECO:0000256|ARBA:ARBA00010532}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSRNOT00000076946.3; ENSRNOP00000068300.2; ENSRNOG00000005906.9. DR AGR; RGD:1565355; -. DR AGR; RGD:41249586; -. DR RGD; 2301; Cd36. DR RGD; 41249586; Cd36-ps1. DR RGD; 1565355; Cd36l1. DR eggNOG; KOG3776; Eukaryota. DR GeneTree; ENSGT00940000153372; -. DR HOGENOM; CLU_019853_0_0_1; -. DR Proteomes; UP000002494; Chromosome 4. DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005901; C:caveola; IEA:TreeGrafter. DR GO; GO:0009986; C:cell surface; IEA:TreeGrafter. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:TreeGrafter. DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:TreeGrafter. DR GO; GO:0005044; F:scavenger receptor activity; IEA:TreeGrafter. DR GO; GO:0150094; P:amyloid-beta clearance by cellular catabolic process; IEA:TreeGrafter. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR GO; GO:0019915; P:lipid storage; IEA:TreeGrafter. DR GO; GO:0042953; P:lipoprotein transport; IEA:TreeGrafter. DR GO; GO:0044539; P:long-chain fatty acid import into cell; IEA:TreeGrafter. DR GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:TreeGrafter. DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:TreeGrafter. DR InterPro; IPR005428; CD36/SCARB1/SNMP1. DR InterPro; IPR002159; CD36_fam. DR PANTHER; PTHR11923:SF12; PLATELET GLYCOPROTEIN 4; 1. DR PANTHER; PTHR11923; SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1; 1. DR Pfam; PF01130; CD36; 1. DR PRINTS; PR01610; CD36ANTIGEN. DR PRINTS; PR01609; CD36FAMILY. PE 1: Evidence at protein level; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR605428-52}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499, KW ECO:0000256|PIRSR:PIRSR605428-51}; KW Lipid transport {ECO:0000256|ARBA:ARBA00023055}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A096MJX7}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843, KW ECO:0000256|PIRSR:PIRSR605428-51}. FT TRANSMEM 7..30 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 425..451 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT SITE 448 FT /note="Critical for TLR4-TLR6 dimerization and signaling" FT /evidence="ECO:0000256|PIRSR:PIRSR605428-50" FT DISULFID 243..311 FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52" FT DISULFID 272..333 FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52" FT DISULFID 313..322 FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52" FT CROSSLNK 454 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in ubiquitin)" FT /evidence="ECO:0000256|PIRSR:PIRSR605428-51" FT CROSSLNK 457 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in ubiquitin)" FT /evidence="ECO:0000256|PIRSR:PIRSR605428-51" SQ SEQUENCE 457 AA; 50933 MW; 4D20180AB7615422 CRC64; MGCDRNCGLI TGAVIGAVLA VFGGILMPVG DLLIEKTIKR EVVLEEGTIA FKNWVKTGTT VYRQFWIFDV QNPEEVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPKDS TVSFVQPNGA IFEPSLSVGT ENDNFTVLNL AVAAAPHIYT NSFVQGVLNS LIKKSKSSMF QTRSLKELLW GYKDPFLSLV PYPISTTVGV FYPYNNTVDG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SYCDMINGTD AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEVNLKGIPV YRFVLPANAF ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL NPNEDEHRTY LDVEPVSHYL TDLINILLMK LSRRIKLISS YSDTGTIGDE KAEMFRNQVT GKIKLLGLVE MVLLGVGVVM FVAFMISYCA CRSKNGK //