ID A0A096LP07_HUMAN Unreviewed; 486 AA. AC A0A096LP07; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 05-JUN-2019, entry version 45. DE SubName: Full=COP9 signalosome complex subunit 1 {ECO:0000313|Ensembl:ENSP00000485330}; GN Name=GPS1 {ECO:0000313|Ensembl:ENSP00000485330}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000485330, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000213|PubMed:16964243} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein RT phosphorylation analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000485330, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in RT the human lineage."; RL Nature 440:1045-1049(2006). RN [3] {ECO:0000213|PubMed:17525332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=17525332; DOI=10.1126/science.1140321; RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., Hurov K.E., RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., RA Shiloh Y., Gygi S.P., Elledge S.J.; RT "ATM and ATR substrate analysis reveals extensive protein networks RT responsive to DNA damage."; RL Science 316:1160-1166(2007). RN [4] {ECO:0000213|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [5] {ECO:0000213|PubMed:19413330} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [6] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [7] {ECO:0000213|PubMed:20068231} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., RA Mann M.; RT "Quantitative phosphoproteomics reveals widespread full RT phosphorylation site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [8] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] {ECO:0000213|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., RA Blagoev B.; RT "System-wide temporal characterization of the proteome and RT phosphoproteome of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [10] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [11] {ECO:0000313|Ensembl:ENSP00000485330} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC135056; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001317468.1; NM_001330539.1. DR jPOST; A0A096LP07; -. DR PeptideAtlas; A0A096LP07; -. DR Ensembl; ENST00000623691; ENSP00000485330; ENSG00000169727. DR GeneID; 2873; -. DR UCSC; uc060luz.1; human. DR CTD; 2873; -. DR HGNC; HGNC:4549; GPS1. DR OpenTargets; ENSG00000169727; -. DR eggNOG; KOG0686; Eukaryota. DR eggNOG; ENOG410XRXI; LUCA. DR GeneTree; ENSGT00510000046608; -. DR OrthoDB; 859626at2759; -. DR ChiTaRS; GPS1; human. DR GenomeRNAi; 2873; -. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000169727; Expressed in 207 organ(s), highest expression level in right hemisphere of cerebellum. DR ExpressionAtlas; A0A096LP07; baseline and differential. DR GO; GO:0008180; C:COP9 signalosome; IEA:InterPro. DR GO; GO:0000338; P:protein deneddylation; IEA:InterPro. DR InterPro; IPR033008; CSN1. DR InterPro; IPR000717; PCI_dom. DR InterPro; IPR019585; Rpn7/CSN1. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR14145:SF2; PTHR14145:SF2; 1. DR Pfam; PF01399; PCI; 1. DR Pfam; PF10602; RPN7; 1. DR SMART; SM00088; PINT; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR PROSITE; PS50250; PCI; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A096LP07, KW ECO:0000213|MaxQB:A0A096LP07, ECO:0000213|PeptideAtlas:A0A096LP07}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 264 426 PCI. {ECO:0000259|PROSITE:PS50250}. FT REGION 460 486 Disordered. {ECO:0000256|MobiDB-lite: FT A0A096LP07}. FT COILED 131 151 {ECO:0000256|SAM:Coils}. FT COILED 385 405 {ECO:0000256|SAM:Coils}. FT COMPBIAS 470 486 Polar. {ECO:0000256|MobiDB-lite: FT A0A096LP07}. SQ SEQUENCE 486 AA; 54965 MW; 04D4D1A21556ADCF CRC64; MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP SLDLEQYAAS YSGLMRIERL QFIADHCPTL RVEALKMALS FVQRTFNVDM YEEIHRKLSE ATRELQNAPD AIPESGVEPP ALDTAWVEAT RKKALLKLEK LDTDLKNYKG NSIKESIRRG HDDLGDHYLD CGDLSNALKC YSRARDYCTS AKHVINMCLN VIKVSVYLQN WSHVLSYVSK AESTPEIAER GERDSQTQAI LTKLKCAAGL AELAARKYKQ AAKCLLLASF DHCDFPELLS PSNVAIYGGL CALATFDRQE LQRNVISSSS FKLFLELEPQ VRDIIFKFYE SKYASCLKML DEMKDNLLLD MYLAPHVRTL YTQIRNRALI QYFSPYVSAD MHRMAAAFNT TVAALEDELT QLILEGLISA RVDSHSKILY ARDVDQRSTT FEKSLLMGKE FQRRAKAMML RAAVLRNQIH VKSPPREGSQ GELTPANSQS RMSTNM //