ID   A0A094ZWQ2_SCHHA        Unreviewed;       266 AA.
AC   A0A094ZWQ2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   18-SEP-2019, entry version 18.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KGB39290.1};
GN   ORFNames=MS3_07706 {ECO:0000313|EMBL:KGB39290.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB39290.1, ECO:0000313|Proteomes:UP000054474};
RN   [1] {ECO:0000313|EMBL:KGB39290.1, ECO:0000313|Proteomes:UP000054474}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A.,
RA   Oliveira G., Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E.,
RA   Loukas A., Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J.,
RA   Yang H., Wang J., Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
RN   [2] {ECO:0000213|PDB:5TIV, ECO:0000213|PDB:5TIW, ECO:0000213|PDB:5TIX}
RP   X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) OF 17-266 IN COMPLEX WITH
RP   CALCIUM.
RX   PubMed=28536265; DOI=10.1074/jbc.M116.766527;
RA   Taylor A.B., Roberts K.M., Cao X., Clark N.E., Holloway S.P.,
RA   Donati E., Polcaro C.M., Pica-Mattoccia L., Tarpley R.S.,
RA   McHardy S.F., Cioli D., LoVerde P.T., Fitzpatrick P.F., Hart P.J.;
RT   "Structural and enzymatic insights into species-specific resistance to
RT   schistosome parasite drug therapy.";
RL   J. Biol. Chem. 292:11154-11164(2017).
RN   [3] {ECO:0000213|PDB:6B51, ECO:0000213|PDB:6B52, ECO:0000213|PDB:6B53}
RP   X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 17-266.
RA   LoVerde P.T.;
RT   "Why does oxamniquine kill Schistosoma mansoni and not S. haematobium
RT   and S. japonicum?.";
RL   Submitted (SEP-2017) to the PDB data bank.
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DR   EMBL; KL251171; KGB39290.1; -; Genomic_DNA.
DR   RefSeq; XP_012799050.1; XM_012943596.1.
DR   PDB; 5TIV; X-ray; 1.43 A; A=17-266.
DR   PDB; 5TIW; X-ray; 1.66 A; A/B=17-266.
DR   PDB; 5TIX; X-ray; 1.78 A; A/B=17-266.
DR   PDB; 5TIY; X-ray; 1.76 A; A=17-266.
DR   PDB; 6B51; X-ray; 2.05 A; A=17-266.
DR   PDB; 6B52; X-ray; 1.80 A; A=17-266.
DR   PDB; 6B53; X-ray; 1.60 A; A/B=17-266.
DR   PDB; 6B54; X-ray; 1.80 A; A=17-266.
DR   PDBsum; 5TIV; -.
DR   PDBsum; 5TIW; -.
DR   PDBsum; 5TIX; -.
DR   PDBsum; 5TIY; -.
DR   PDBsum; 6B51; -.
DR   PDBsum; 6B52; -.
DR   PDBsum; 6B53; -.
DR   PDBsum; 6B54; -.
DR   SMR; A0A094ZWQ2; -.
DR   GeneID; 24595004; -.
DR   KEGG; shx:MS3_07706; -.
DR   CTD; 24595004; -.
DR   OrthoDB; 1399085at2759; -.
DR   Proteomes; UP000054474; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR040632; Sulfotransfer_4.
DR   Pfam; PF17784; Sulfotransfer_4; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:5TIV, ECO:0000213|PDB:5TIW,
KW   ECO:0000213|PDB:5TIX, ECO:0000213|PDB:5TIY};
KW   Calcium {ECO:0000213|PDB:5TIW};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054474};
KW   Metal-binding {ECO:0000213|PDB:5TIW}.
FT   METAL        74     74       Calcium 1; via carbonyl oxygen.
FT                                {ECO:0000213|PDB:5TIW}.
FT   METAL        76     76       Calcium 1; via carbonyl oxygen.
FT                                {ECO:0000213|PDB:5TIW}.
FT   METAL        79     79       Calcium 1. {ECO:0000213|PDB:5TIW}.
FT   METAL       157    157       Calcium 2; via carbonyl oxygen.
FT                                {ECO:0000213|PDB:5TIW}.
FT   METAL       159    159       Calcium 2. {ECO:0000213|PDB:5TIW}.
FT   METAL       185    185       Calcium 3. {ECO:0000213|PDB:5TIW}.
FT   METAL       189    189       Calcium 3. {ECO:0000213|PDB:5TIW}.
SQ   SEQUENCE   266 AA;  30773 MW;  FE00E6E6FFA0D295 CRC64;
     MTIDPLVIIM MMETSPSTTS TTIQVIGAGL PRTGTNSMKK ALEIIYSKPC YHMYEIIFKK
     QSDISIWQQL IDETHKTTSD KRKIYNGLNE LLNGYIATTD LPSCSFYKEL MTMYPNAKVL
     LTIRDKYDWL YSLRKVVLPK STDPWKLKIE EGDQVLGIDS NFYKMSEDSL KFAFQKNHIN
     LDDDEILLEC YDEYNRLVQE IVPPERLLIH HLGDGWESLC QFLNVDIPNG ISYPCANSHH
     QMTQLTEQLI KHKSLDDIIH MFPGLI
//