ID A0A091UJQ6_PHORB Unreviewed; 393 AA. AC A0A091UJQ6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 29-MAY-2024, entry version 20. DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365}; DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728}; DE Flags: Fragment; GN ORFNames=N337_11537 {ECO:0000313|EMBL:KFQ90412.1}; OS Phoenicopterus ruber ruber. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; Phoenicopteridae; OC Phoenicopterus. OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ90412.1, ECO:0000313|Proteomes:UP000053700}; RN [1] {ECO:0000313|EMBL:KFQ90412.1, ECO:0000313|Proteomes:UP000053700} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ90412.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004265}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the MPEG1 family. CC {ECO:0000256|ARBA:ARBA00007256}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KK436749; KFQ90412.1; -; Genomic_DNA. DR AlphaFoldDB; A0A091UJQ6; -. DR Proteomes; UP000053700; Unassembled WGS sequence. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0042742; P:defense response to bacterium; IEA:TreeGrafter. DR InterPro; IPR020864; MACPF. DR InterPro; IPR039707; MPEG1. DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1. DR Pfam; PF01823; MACPF; 1. DR SMART; SM00457; MACPF; 1. DR PROSITE; PS51412; MACPF_2; 1. PE 3: Inferred from homology; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00023130}; KW Membrane {ECO:0000256|ARBA:ARBA00022989}; KW Reference proteome {ECO:0000313|Proteomes:UP000053700}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT DOMAIN 1..300 FT /note="MACPF" FT /evidence="ECO:0000259|PROSITE:PS51412" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:KFQ90412.1" FT NON_TER 393 FT /evidence="ECO:0000313|EMBL:KFQ90412.1" SQ SEQUENCE 393 AA; 43531 MW; 232F2C46C511A55D CRC64; LPGGGWDNLR NLDMGRVINL GYSLCKTTED GSYIIPDEIF TIPRKQSNLD INSEIIESWK DYQSITSASI NLELSLFSAI NGKFSYDFHR TKTHQVKDRA VTTRVQVRNL VYTAKIDPGA VLDKSFKKQL LLIASHLENN QTRMADFLAE VLVLNYGTHT ITSVDAGASL VQEDQIKATF LKDSLATRTA VTTSAGVAFH SIIGVKNEES LDVSSGFTKQ YMENRTNSRV ESIGGTPFYP GITLKTWQEG IRNQLVALDR SGLPLYFFIN PGTLPELPTP GPPRRYYTFN TYLGCTDATS PNFNFHANAD DGSCEGAMTN FTFGGVFQEC AGLAGPDTSA LCRELEQRNP LTGAFSCPPT YTPVLLGVQE REEGHSHLEC HDKCTLRIFC HRE //