ID A0A091NPX7_APAVI Unreviewed; 329 AA. AC A0A091NPX7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 27-MAR-2024, entry version 37. DE RecName: Full=Prostaglandin reductase 1 {ECO:0000256|ARBA:ARBA00020651}; DE EC=1.3.1.48 {ECO:0000256|ARBA:ARBA00011981}; DE EC=1.3.1.74 {ECO:0000256|ARBA:ARBA00012410}; DE AltName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00033119}; DE AltName: Full=Dithiolethione-inducible gene 1 protein {ECO:0000256|ARBA:ARBA00032255}; DE AltName: Full=Leukotriene B4 12-hydroxydehydrogenase {ECO:0000256|ARBA:ARBA00031851}; DE AltName: Full=NAD(P)H-dependent alkenal/one oxidoreductase {ECO:0000256|ARBA:ARBA00032297}; GN ORFNames=N311_11777 {ECO:0000313|EMBL:KFP90999.1}; OS Apaloderma vittatum (Bar-tailed trogon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Trogoniformes; Trogonidae; Apaloderma. OX NCBI_TaxID=57397 {ECO:0000313|EMBL:KFP90999.1, ECO:0000313|Proteomes:UP000054244}; RN [1] {ECO:0000313|EMBL:KFP90999.1, ECO:0000313|Proteomes:UP000054244} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N311 {ECO:0000313|EMBL:KFP90999.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + CC NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + CC H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974, CC ChEBI:CHEBI:133975; Evidence={ECO:0000256|ARBA:ARBA00023498}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213; CC Evidence={ECO:0000256|ARBA:ARBA00023498}; CC -!- CATALYTIC ACTIVITY: CC Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin CC F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, CC ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590; CC Evidence={ECO:0000256|ARBA:ARBA00023548}; CC -!- CATALYTIC ACTIVITY: CC Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15- CC oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, CC ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; CC Evidence={ECO:0000256|ARBA:ARBA00023544}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586; CC Evidence={ECO:0000256|ARBA:ARBA00023544}; CC -!- CATALYTIC ACTIVITY: CC Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15- CC oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, CC ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; CC Evidence={ECO:0000256|ARBA:ARBA00023543}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594; CC Evidence={ECO:0000256|ARBA:ARBA00023543}; CC -!- CATALYTIC ACTIVITY: CC Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy- CC leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783, CC ChEBI:CHEBI:58349, ChEBI:CHEBI:133346; CC Evidence={ECO:0000256|ARBA:ARBA00023517}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209; CC Evidence={ECO:0000256|ARBA:ARBA00023517}; CC -!- CATALYTIC ACTIVITY: CC Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + CC NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, CC ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112; CC Evidence={ECO:0000256|ARBA:ARBA00023553}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738; CC Evidence={ECO:0000256|ARBA:ARBA00023553}; CC -!- CATALYTIC ACTIVITY: CC Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy- CC (6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; CC Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, CC ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974; CC Evidence={ECO:0000256|ARBA:ARBA00023496}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205; CC Evidence={ECO:0000256|ARBA:ARBA00023496}; CC -!- CATALYTIC ACTIVITY: CC Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH; CC Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, CC ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457; CC Evidence={ECO:0000256|ARBA:ARBA00023696}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618; CC Evidence={ECO:0000256|ARBA:ARBA00023696}; CC -!- CATALYTIC ACTIVITY: CC Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH; CC Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748; CC Evidence={ECO:0000256|ARBA:ARBA00023504}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782; CC Evidence={ECO:0000256|ARBA:ARBA00023504}; CC -!- CATALYTIC ACTIVITY: CC Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH; CC Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276; CC Evidence={ECO:0000256|ARBA:ARBA00024160}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790; CC Evidence={ECO:0000256|ARBA:ARBA00024160}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; CC Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; CC Evidence={ECO:0000256|ARBA:ARBA00023507}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739; CC Evidence={ECO:0000256|ARBA:ARBA00023507}; CC -!- CATALYTIC ACTIVITY: CC Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH; CC Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455; CC Evidence={ECO:0000256|ARBA:ARBA00023691}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614; CC Evidence={ECO:0000256|ARBA:ARBA00023691}; CC -!- CATALYTIC ACTIVITY: CC Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH; CC Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741; CC Evidence={ECO:0000256|ARBA:ARBA00023530}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786; CC Evidence={ECO:0000256|ARBA:ARBA00023530}; CC -!- CATALYTIC ACTIVITY: CC Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH; CC Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; CC Evidence={ECO:0000256|ARBA:ARBA00034052}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778; CC Evidence={ECO:0000256|ARBA:ARBA00034052}; CC -!- CATALYTIC ACTIVITY: CC Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + CC NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309; CC Evidence={ECO:0000256|ARBA:ARBA00023545}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609; CC Evidence={ECO:0000256|ARBA:ARBA00023545}; CC -!- SUBUNIT: Monomer or homodimer. {ECO:0000256|ARBA:ARBA00011852}. CC -!- SIMILARITY: Belongs to the NADP-dependent oxidoreductase L4BD family. CC {ECO:0000256|ARBA:ARBA00010460}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KL389160; KFP90999.1; -; Genomic_DNA. DR RefSeq; XP_009872079.1; XM_009873777.1. DR AlphaFoldDB; A0A091NPX7; -. DR GeneID; 104277204; -. DR KEGG; avit:104277204; -. DR CTD; 22949; -. DR OrthoDB; 179761at2759; -. DR Proteomes; UP000054244; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0036132; F:13-prostaglandin reductase activity; IEA:UniProtKB-EC. DR GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0032440; F:2-alkenal reductase [NAD(P)+] activity; IEA:UniProtKB-EC. DR CDD; cd08294; leukotriene_B4_DH_like; 1. DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR InterPro; IPR013149; ADH-like_C. DR InterPro; IPR041694; ADH_N_2. DR InterPro; IPR011032; GroES-like_sf. DR InterPro; IPR045010; MDR_fam. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR020843; PKS_ER. DR InterPro; IPR014190; PTGR1. DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1. DR PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1. DR Pfam; PF16884; ADH_N_2; 1. DR Pfam; PF00107; ADH_zinc_N; 1. DR SMART; SM00829; PKS_ER; 1. DR SUPFAM; SSF50129; GroES-like; 2. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. PE 3: Inferred from homology; KW Acetylation {ECO:0000256|ARBA:ARBA00022990}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022501}; KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022501}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}; KW Prostaglandin metabolism {ECO:0000256|ARBA:ARBA00022501}; KW Reference proteome {ECO:0000313|Proteomes:UP000054244}. FT DOMAIN 15..327 FT /note="Enoyl reductase (ER)" FT /evidence="ECO:0000259|SMART:SM00829" SQ SEQUENCE 329 AA; 36227 MW; 9B6277F0A5E0D7DC CRC64; MVTAKVWVLK KHFQGFPKLS DFDLKQIELP NLKDGELLLE SVFLSVDPYM RPYSQRDMKE GDIMIGTQVA RIVESKNPAF KVGAFVVGRS GWRTHFISDG KDLQFLPSSW PESLPRSLAL GTVGMPGLTA YFGLLDVCKM KPGETVLVNA AAGAVGSVVG QLAKIGGCKV VGCAGSDDKV AYLKKIGFDE AFNYKTVTSL DEALRKASPD GYDCFFDNVG GEFTSIAINQ MKKYGRIAVC GAISQYNDSV PQKGPYIQIP LIFKELRVEG FIVSRWSNRW EEGMKALLKW VVEGKVKYHE QVTEGFENMP AAFIGMLKGE NLGKAIVKV //