ID A0A091NPX7_APAVI Unreviewed; 329 AA. AC A0A091NPX7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 12-AUG-2020, entry version 21. DE RecName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00013509}; DE EC=1.3.1.48 {ECO:0000256|ARBA:ARBA00011981}; DE EC=1.3.1.74 {ECO:0000256|ARBA:ARBA00012410}; DE AltName: Full=NADP-dependent leukotriene B4 12-hydroxydehydrogenase {ECO:0000256|ARBA:ARBA00018667}; DE AltName: Full=Prostaglandin reductase 1 {ECO:0000256|ARBA:ARBA00020651}; GN ORFNames=N311_11777 {ECO:0000313|EMBL:KFP90999.1}; OS Apaloderma vittatum (Bar-tailed trogon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Trogoniformes; Trogonidae; Apaloderma. OX NCBI_TaxID=57397 {ECO:0000313|EMBL:KFP90999.1, ECO:0000313|Proteomes:UP000054244}; RN [1] {ECO:0000313|EMBL:KFP90999.1, ECO:0000313|Proteomes:UP000054244} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N311 {ECO:0000313|EMBL:KFP90999.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15- CC oxoprostaglandin E2 + H(+) + NADH; Xref=Rhea:RHEA:11916, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.48; CC Evidence={ECO:0000256|ARBA:ARBA00000916}; CC -!- CATALYTIC ACTIVITY: CC Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15- CC oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48; CC Evidence={ECO:0000256|ARBA:ARBA00001800}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH; CC Xref=Rhea:RHEA:13733, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.74; CC Evidence={ECO:0000256|ARBA:ARBA00001474}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; CC Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; CC Evidence={ECO:0000256|ARBA:ARBA00000199}; CC -!- SUBUNIT: Monomer or homodimer. {ECO:0000256|ARBA:ARBA00011852}. CC -!- SIMILARITY: Belongs to the NADP-dependent oxidoreductase L4BD family. CC {ECO:0000256|ARBA:ARBA00010460}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KL389160; KFP90999.1; -; Genomic_DNA. DR RefSeq; XP_009872079.1; XM_009873777.1. DR GeneID; 104277204; -. DR CTD; 22949; -. DR OrthoDB; 884151at2759; -. DR Proteomes; UP000054244; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:InterPro. DR GO; GO:0032440; F:2-alkenal reductase [NAD(P)+] activity; IEA:InterPro. DR CDD; cd08294; leukotriene_B4_DH_like; 1. DR InterPro; IPR013149; ADH_C. DR InterPro; IPR041694; ADH_N_2. DR InterPro; IPR011032; GroES-like_sf. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR020843; PKS_ER. DR InterPro; IPR014190; PTGR1. DR Pfam; PF16884; ADH_N_2; 1. DR Pfam; PF00107; ADH_zinc_N; 1. DR SMART; SM00829; PKS_ER; 1. DR SUPFAM; SSF50129; SSF50129; 2. DR SUPFAM; SSF51735; SSF51735; 1. PE 3: Inferred from homology; KW Acetylation {ECO:0000256|ARBA:ARBA00022990}; KW Reference proteome {ECO:0000313|Proteomes:UP000054244}. FT DOMAIN 15..327 FT /note="PKS_ER" FT /evidence="ECO:0000259|SMART:SM00829" SQ SEQUENCE 329 AA; 36227 MW; 9B6277F0A5E0D7DC CRC64; MVTAKVWVLK KHFQGFPKLS DFDLKQIELP NLKDGELLLE SVFLSVDPYM RPYSQRDMKE GDIMIGTQVA RIVESKNPAF KVGAFVVGRS GWRTHFISDG KDLQFLPSSW PESLPRSLAL GTVGMPGLTA YFGLLDVCKM KPGETVLVNA AAGAVGSVVG QLAKIGGCKV VGCAGSDDKV AYLKKIGFDE AFNYKTVTSL DEALRKASPD GYDCFFDNVG GEFTSIAINQ MKKYGRIAVC GAISQYNDSV PQKGPYIQIP LIFKELRVEG FIVSRWSNRW EEGMKALLKW VVEGKVKYHE QVTEGFENMP AAFIGMLKGE NLGKAIVKV //