ID A0A091EJH1_FUKDA Unreviewed; 904 AA. AC A0A091EJH1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 14-DEC-2022, entry version 17. DE RecName: Full=alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase {ECO:0000256|ARBA:ARBA00012671}; DE EC=2.4.1.155 {ECO:0000256|ARBA:ARBA00012671}; GN ORFNames=H920_02880 {ECO:0000313|EMBL:KFO35651.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; OC Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO35651.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO35651.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO35651.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man- CC (1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)- CC beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N- CC acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta- CC D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D- CC GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc- CC (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP; CC Xref=Rhea:RHEA:16921, Rhea:RHEA-COMP:14374, Rhea:RHEA-COMP:14377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, CC ChEBI:CHEBI:139507, ChEBI:CHEBI:139510; EC=2.4.1.155; CC Evidence={ECO:0000256|ARBA:ARBA00000454}; CC -!- PATHWAY: Protein modification; protein glycosylation. CC {ECO:0000256|ARBA:ARBA00004922}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004323}. Membrane CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004606}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 18 family. CC {ECO:0000256|ARBA:ARBA00007477}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KN121670; KFO35651.1; -; Genomic_DNA. DR AlphaFoldDB; A0A091EJH1; -. DR STRING; 885580.XP_010616772.1; -. DR eggNOG; ENOG502QWJG; Eukaryota. DR UniPathway; UPA00378; -. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030144; F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0006487; P:protein N-linked glycosylation; IEA:InterPro. DR InterPro; IPR026116; GlyclTrfase_18. DR Pfam; PF15024; Glyco_transf_18; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, KW ECO:0000313|EMBL:KFO35651.1}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFO35651.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 110..131 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 904 AA; 101087 MW; 0E0DF7B48E4EB419 CRC64; MPGPHLASLS PGGLLHADLE EGPPLRALLY IVSPGRVKVP EHLPPLTAPK AALPAQFSSS GLSLSVEDQE PELGLGVVLC LVPCCLPGSL TSLPTRVAAH VLLRHSMSRL FVLGIGFFTL CFLMTSLGGQ FSARRLGDSP FTIRTEVLGG AESRGVLRKM SDLLELMVKR VDMLARLENS SELHRAAASG SSGESKFAIF AWENIIREAD CCKQHHIMDP KAKWFSPGAG LMERIQAIAQ NVSDIAVKVD QILRHSLLLH SKVSEGRQDQ CEAPSDPKFP DCPGKVEWMR ARWTSDPCYA FFGVDGTECS FLIYLSEVEW FCPPLPWRNK TRAQMAPKAL PRVQTVFRSN LSHLLELMGS GKESLIFMKK RTKRLTSQWA TAARRLAQKL GDIRREQKQI LVHIGFLTEE SGDVFSPRVL KGGPLGEMVQ WADILAALYV LGHSLRVTVS LKELQSNLGV PPGRGNCPLT MPLPFDLIYT DYHGLQQMKQ HMGLSFKKYR CRIRVIDTFG TEPAYNHEEY ATLHGYRTNW GYWNLNPKQF MTMFPHTPDN SFMGFVSEEL NETEKQLIKG GKASNMAVVY GKEASIWKGK EKFLAILNKY MEIHGTVYYE SQRPPEVPAF VKNHGLLPQP EFQQLLRKAK LFIGFGFPYE GPAPLEAIAN GCVFLQSRFS PPHSSLNHEF FRGKPTSREV FSQHPYAENF IGKPHVWTVD YNNSEEFEAA IKTIMKTQVD PYLPYEYTCE GMLERIHAYI QHQDFCAAPG PTLPGAHAAQ SPFVLAPNAT HLEWARNASL APGAWPPTRS LRAWLAAPGR ACTDACLDHG LICEPSFFPF LNSRDAFLKL QVPCDSTEWE MHHLYPALAQ PGQECYLQKE PLLFSCAGAS TKYQRLCPCR DFRKGQVALC QGCL //