ID A0A090X4L7_9FLAO Unreviewed; 490 AA. AC A0A090X4L7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 16-MAR-2016, entry version 14. DE RecName: Full=Inosine-5'-monophosphate dehydrogenase {ECO:0000256|RuleBase:RU003928}; DE EC=1.1.1.205 {ECO:0000256|RuleBase:RU003928}; GN ORFNames=JCM19274_4501 {ECO:0000313|EMBL:GAL78002.1}; OS Algibacter lectus. OC Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales; OC Flavobacteriaceae; Algibacter. OX NCBI_TaxID=221126 {ECO:0000313|EMBL:GAL78002.1, ECO:0000313|Proteomes:UP000029643}; RN [1] {ECO:0000313|EMBL:GAL78002.1, ECO:0000313|Proteomes:UP000029643} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JCM19274 {ECO:0000313|Proteomes:UP000029643}; RA Takatani N., Nakanishi M., Meirelles P., Mino S., Suda W., Oshima K., RA Hattori M., Ohkuma M., Hosokawa M., Miyashita K., Thompson F.L., RA Niwa A., Sawabe T., Sawabe T.; RT "Draft Genome Sequences of Marine Flavobacterium Algibacter lectus RT Strains SS8 and NR4."; RL Genome Announc. 2:e01168-14(2014). CC -!- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NAD(+) + H(2)O = CC xanthosine 5'-phosphate + NADH. {ECO:0000256|RuleBase:RU003928}. CC -!- PATHWAY: Purine metabolism; XMP biosynthesis via de novo pathway; CC XMP from IMP: step 1/1. {ECO:0000256|RuleBase:RU003928}. CC -!- SIMILARITY: Belongs to the IMPDH/GMPR family. CC {ECO:0000256|RuleBase:RU003927}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:GAL78002.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BBNU01000002; GAL78002.1; -; Genomic_DNA. DR RefSeq; WP_042495518.1; NZ_BBNU01000002.1. DR EnsemblBacteria; GAL78002; GAL78002; JCM19274_4501. DR UniPathway; UPA00601; UER00295. DR Proteomes; UP000029643; Unassembled WGS sequence. DR GO; GO:0003938; F:IMP dehydrogenase activity; IEA:UniProtKB-EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006177; P:GMP biosynthetic process; IEA:UniProtKB-KW. DR Gene3D; 3.20.20.70; -; 1. DR HAMAP; MF_01964; IMPDH; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR000644; CBS_dom. DR InterPro; IPR005990; IMP_DH. DR InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS. DR InterPro; IPR001093; IMP_DH_GMPRt. DR PANTHER; PTHR11911:SF6; PTHR11911:SF6; 2. DR Pfam; PF00571; CBS; 2. DR Pfam; PF00478; IMPDH; 1. DR PIRSF; PIRSF000130; IMPDH; 1. DR SMART; SM00116; CBS; 2. DR TIGRFAMs; TIGR01302; IMP_dehydrog; 1. DR PROSITE; PS51371; CBS; 2. DR PROSITE; PS00487; IMP_DH_GMP_RED; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029643}; KW GMP biosynthesis {ECO:0000256|RuleBase:RU003928}; KW Metal-binding {ECO:0000256|RuleBase:RU003928}; KW NAD {ECO:0000256|PIRSR:PIRSR000130-3, ECO:0000256|RuleBase:RU003928}; KW Oxidoreductase {ECO:0000256|RuleBase:RU003927, KW ECO:0000313|EMBL:GAL78002.1}; KW Potassium {ECO:0000256|PIRSR:PIRSR000130-4, KW ECO:0000256|RuleBase:RU003928}; KW Purine biosynthesis {ECO:0000256|RuleBase:RU003928}. FT DOMAIN 97 153 CBS. {ECO:0000259|PROSITE:PS51371}. FT DOMAIN 157 214 CBS. {ECO:0000259|PROSITE:PS51371}. FT NP_BIND 251 253 NAD. {ECO:0000256|PIRSR:PIRSR000130-3}. FT NP_BIND 301 303 NAD. {ECO:0000256|PIRSR:PIRSR000130-3}. FT REGION 341 343 IMP binding. {ECO:0000256|PIRSR: FT PIRSR000130-2}. FT REGION 364 365 IMP binding. {ECO:0000256|PIRSR: FT PIRSR000130-2}. FT REGION 388 392 IMP binding. {ECO:0000256|PIRSR: FT PIRSR000130-2}. FT ACT_SITE 308 308 Thioimidate intermediate. FT {ECO:0000256|PIRSR:PIRSR000130-1}. FT ACT_SITE 404 404 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR000130-1}. FT METAL 303 303 Potassium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000130-4}. FT METAL 305 305 Potassium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000130-4}. FT METAL 308 308 Potassium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000130-4}. FT BINDING 306 306 IMP. {ECO:0000256|PIRSR:PIRSR000130-2}. FT BINDING 419 419 IMP. {ECO:0000256|PIRSR:PIRSR000130-2}. SQ SEQUENCE 490 AA; 52108 MW; 6875B10DE404887F CRC64; MTAHENKIVG EGLTYDDVLL VPAFSEVLPR EVSIQTKFTR NITINVPIIS AAMDTVTESK MAIAMAQEGG IGVLHKNMSI EAQALKVRRV KRAESGMIID PVTLPVTAVV SDAKKYMAEY SIGGIPIVAE DGTLKGIVTN RDLRFEHNGK RAISEVMTSE KLVTASVGTS LKDAELILQE HKIEKLLIVD DNFKLSGLIT FRDITKLSQK PNANKDQYGR LRVAAALGVT ADAVERAEAL VNAGVDAVVI DTAHGHTKGV VSVLKTIKAK FPNLDVIVGN IATGAAAKYL VEAGADAVKV GIGPGSICTT RVVAGVGFPQ FSAVLEVAAA IKGSGVPVIA DGGIRYTGDI PKAIAAGADT VMLGSLLAGT KESPGETIIY EGRKFKSYRG MGSVEAMKEG SKDRYFQDVE DDIKKLVPEG IVGRVPYKGD LYESIHQFIG GLRAGMGYCG AKDIETLKET GQFVKITASG INESHPHDVT ITKESPNYSR //