ID A0A090PFJ0_9FLAO Unreviewed; 572 AA. AC A0A090PFJ0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 15. DE RecName: Full=Urocanate hydratase {ECO:0000256|SAAS:SAAS00693702}; DE EC=4.2.1.49 {ECO:0000256|SAAS:SAAS00693702}; GN ORFNames=JCM19297_1268 {ECO:0000313|EMBL:GAK89440.1}; OS Nonlabens ulvanivorans. OC Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales; OC Flavobacteriaceae; Nonlabens. OX NCBI_TaxID=906888 {ECO:0000313|EMBL:GAK89440.1, ECO:0000313|Proteomes:UP000029220}; RN [1] {ECO:0000313|EMBL:GAK89440.1, ECO:0000313|Proteomes:UP000029220} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JCM19297 {ECO:0000313|Proteomes:UP000029220}; RA Nakanishi M., Meirelles P., Suzuki R., Takatani N., Mino S., Suda W., RA Oshima K., Hattori M., Ohkuma M., Hosokawa M., Miyashita K., RA Thompson F.L., Niwa A., Sawabe T., Sawabe T.; RT "Draft Genome Sequences of Marine Flavobacterium Nonlabens Strains RT NR17, NR24, NR27, NR32, NR33, and Ara13."; RL Genome Announc. 2:e01165-14(2014). CC -!- CATALYTIC ACTIVITY: 3-(5-oxo-4,5-dihydro-3H-imidazol-4- CC yl)propanoate = urocanate + H(2)O. CC {ECO:0000256|SAAS:SAAS00693674}. CC -!- COFACTOR: CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; CC Evidence={ECO:0000256|SAAS:SAAS00693694}; CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L- CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3. CC {ECO:0000256|SAAS:SAAS00693692}. CC -!- SIMILARITY: Belongs to the urocanase family. CC {ECO:0000256|SAAS:SAAS00693689}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:GAK89440.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BBMJ01000003; GAK89440.1; -; Genomic_DNA. DR UniPathway; UPA00379; UER00550. DR Proteomes; UP000029220; Unassembled WGS sequence. DR GO; GO:0016153; F:urocanate hydratase activity; IEA:UniProtKB-EC. DR GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway. DR GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. DR InterPro; IPR023637; Urocanase. DR InterPro; IPR035401; Urocanase_C. DR InterPro; IPR035400; Urocanase_N. DR InterPro; IPR035085; Urocanase_Rossmann-like. DR InterPro; IPR036190; Urocanase_sf. DR PANTHER; PTHR12216; PTHR12216; 1. DR Pfam; PF01175; Urocanase; 1. DR Pfam; PF17392; Urocanase_C; 1. DR Pfam; PF17391; Urocanase_N; 1. DR PIRSF; PIRSF001423; Urocanate_hydrat; 1. DR SUPFAM; SSF111326; SSF111326; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029220}; KW Histidine metabolism {ECO:0000256|SAAS:SAAS00693681}; KW Lyase {ECO:0000256|SAAS:SAAS00693676, ECO:0000313|EMBL:GAK89440.1}; KW NAD {ECO:0000256|SAAS:SAAS00693683}. FT DOMAIN 93 219 Urocanase_N. {ECO:0000259|Pfam:PF17391}. FT DOMAIN 222 435 Urocanase. {ECO:0000259|Pfam:PF01175}. FT DOMAIN 440 539 Urocanase_C. {ECO:0000259|Pfam:PF17392}. SQ SEQUENCE 572 AA; 64762 MW; B6817CA5ACE92FEB CRC64; MQTAVDNSLV RFRESIKQGI PETLPAPHIY NTNVNHAPKR KKILSADEEE LALRNALRYF EPQHHAVLLP EFKKELNDYG RIYMYRFMPD YEIKARNIED YPYRSKQAAA IMLMIQNNLD HAVAQHPHEL ITYGGNGGVF SNWAQYLLTM KYLSEMTDEQ TLAMYSGHPM GLFPSHKGAP RCVVTNGMMI PNYSQPDDWE KFNALGVTQY GQMTAGSYMY IGPQGIVHGT TITVLNAFRK IKQKPTGNIF VTSGLGGMSG AQPKAGNIAG CITICAEMNP KAVHIRHTQG WVDVVIKSTG DLITRVKEAQ IDKETVSIAF EGNIVHVWEA LYEADIHISI GSDQTSLHNP WAGGYYPVDL SFKESNEMMS NRPDEFKKEV QRSLRRHVEA INKHTEKGTY FFDYGNAFLL ESSRADANIA GKDKEFRYPS YVQDIMGPMC FDYGFGPFRW VCASNDPEDL KKTDQIATDV LEQLSQDAPE RIQQQMQDNI KWIKGAQENK LVVGSQARIL YADAQGRIEI ARAFNKAIAD GSIGPVILGL TITMSPEQIL LIEKRLIYMM VHVLPQIWRY RM //