ID A0A088SII8_PLAFA Unreviewed; 728 AA. AC A0A088SII8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 24-JUL-2024, entry version 38. DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808}; DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808}; OS Plasmodium falciparum (malaria parasite P. falciparum). OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Laverania). OX NCBI_TaxID=5833 {ECO:0000313|EMBL:AIO11217.1}; RN [1] {ECO:0000313|EMBL:AIO11217.1} RP NUCLEOTIDE SEQUENCE. RA Tuteja R., Rahman F.; RT "Isolation and characterization of Bloom homologue from Plasmodium RT falciparum."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by CC translocating in the 3'-5' direction.; EC=5.6.2.4; CC Evidence={ECO:0000256|ARBA:ARBA00034617}; CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily. CC {ECO:0000256|ARBA:ARBA00005446}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KM030269; AIO11217.1; -; Genomic_DNA. DR AlphaFoldDB; A0A088SII8; -. DR SMR; A0A088SII8; -. DR VEuPathDB; PlasmoDB:PF3D7_0918600; -. DR VEuPathDB; PlasmoDB:Pf7G8-2_000266600; -. DR VEuPathDB; PlasmoDB:Pf7G8_090023400; -. DR VEuPathDB; PlasmoDB:PfCD01_090022900; -. DR VEuPathDB; PlasmoDB:PfDd2_090023600; -. DR VEuPathDB; PlasmoDB:PfGA01_090022800; -. DR VEuPathDB; PlasmoDB:PfGB4_090023500; -. DR VEuPathDB; PlasmoDB:PfGN01_090023400; -. DR VEuPathDB; PlasmoDB:PfHB3_090023200; -. DR VEuPathDB; PlasmoDB:PfIT_090023100; -. DR VEuPathDB; PlasmoDB:PfKE01_090022900; -. DR VEuPathDB; PlasmoDB:PfKH01_090022800; -. DR VEuPathDB; PlasmoDB:PfKH02_090023300; -. DR VEuPathDB; PlasmoDB:PfML01_090023000; -. DR VEuPathDB; PlasmoDB:PfNF135_090022200; -. DR VEuPathDB; PlasmoDB:PfNF166_090022600; -. DR VEuPathDB; PlasmoDB:PfNF54_090023700; -. DR VEuPathDB; PlasmoDB:PfSD01_090023500; -. DR VEuPathDB; PlasmoDB:PfSN01_090023100; -. DR VEuPathDB; PlasmoDB:PfTG01_090022900; -. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0030894; C:replisome; IEA:TreeGrafter. DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0009378; F:four-way junction helicase activity; IEA:TreeGrafter. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:TreeGrafter. DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter. DR GO; GO:0044806; P:G-quadruplex DNA unwinding; IEA:TreeGrafter. DR GO; GO:0000723; P:telomere maintenance; IEA:TreeGrafter. DR CDD; cd17920; DEXHc_RecQ; 1. DR CDD; cd18794; SF2_C_RecQ; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C-like. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR032284; RecQ_Zn-bd. DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1. DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF16124; RecQ_Zn_bind; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}. FT DOMAIN 64..239 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51192" FT DOMAIN 289..456 FT /note="Helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51194" SQ SEQUENCE 728 AA; 85412 MW; 9596B816E78971AC CRC64; MNEDAMKILN KCSGEKKKGE DLNSCNLLEY YKTKYSSIDI EKAKLILKEQ FLIPDFREKQ LECLNSIKRF EHVLNIMPTG GGKSLIYQVL PLIIEGISIV ISPLISLIQD QIISLRNKKI VAETINSSLN KKENERILDI LKSQDLGNLK VLYITPETAT SGYFIDILYE LYINKKISLI SIDEVHCIST WGSDFRKSYR NLNKILDICP YVRTYCCTAT ATKFVEKDII RNLNFYIFNK DCDNNINNNN INNNNNIHNN NKYDDHNNNC KVLNIVRTSF NRPNLKYIII YSDLIKDEKK NTVCDIINGK RNKGKIGIIY CFKRNTCDEI SKYLREKGIQ ALSYHAGLTN NTRKRIQQKW ISGKTNILVA TIAFGMGIDR KDVSFIIHYN LPKSIENYYQ ESGRCGGSGR ISFCYLFYSK EDVEKLSYII KTSFAHLDMH DVNIEKKYEK EIYNLECVHN LCINEKCIRS QILSYFGETY PNKNLQTNNT SDHNKQTYKN QTHVEKYNFD TANMYHPSDQ NKDNLTDEHF CCSFCYDTKG SRIKIQKVIN LYENKKGSNI SQFYSKGETH EYNYLYTNNG KHKLYDDDTY YSPSGEEPRE KRSTNYYNKY GDKYGDKYDD KYDDKYDEKY DDKYGDRKLL EGIYKLNNKK IKGYIPFQSA SSIIPRQIRD KGIIEVMKEL EKREEELNEK TKNDQEKHKV NKMNLFRSNS MNVKRKHVFS SFKIPRKI //