ID A0A088RI92_9TRYP Unreviewed; 845 AA. AC A0A088RI92; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 07-OCT-2020, entry version 27. DE RecName: Full=Flavodoxin-like domain-containing protein {ECO:0000259|PROSITE:PS50902}; GN ORFNames=LPMP_050730 {ECO:0000313|EMBL:AIN95515.1}; OS Leishmania panamensis. OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania; OC Leishmania guyanensis species complex. OX NCBI_TaxID=5679 {ECO:0000313|EMBL:AIN95515.1, ECO:0000313|Proteomes:UP000063063}; RN [1] {ECO:0000313|EMBL:AIN95515.1, ECO:0000313|Proteomes:UP000063063} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MHOM/PA/94/PSC-1 {ECO:0000313|EMBL:AIN95515.1, RC ECO:0000313|Proteomes:UP000063063}; RX PubMed=25707621; DOI=10.1038/srep08550; RA Llanes A., Restrepo C.M., Vecchio G.D., Anguizola F.J., Lleonart R.; RT "The genome of Leishmania panamensis: insights into genomics of the L. RT (Viannia) subgenus."; RL Sci. Rep. 5:8550-8550(2015). CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|ARBA:ARBA00001966}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP009374; AIN95515.1; -; Genomic_DNA. DR RefSeq; XP_010703837.1; XM_010705535.1. DR STRING; 5679.XP_010703837.1; -. DR EnsemblProtists; AIN95515; AIN95515; LPMP_050730. DR GeneID; 22572151; -. DR KEGG; lpan:LPMP_050730; -. DR eggNOG; KOG1160; Eukaryota. DR KO; K15449; -. DR OrthoDB; 731783at2759; -. DR Proteomes; UP000063063; Chromosome 5 sequence. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0010181; F:FMN binding; IEA:InterPro. DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW. DR GO; GO:0008033; P:tRNA processing; IEA:InterPro. DR InterPro; IPR008254; Flavodoxin/NO_synth. DR InterPro; IPR029039; Flavoprotein-like_sf. DR InterPro; IPR007197; rSAM. DR InterPro; IPR013917; tRNA_wybutosine-synth. DR InterPro; IPR034556; tRNA_wybutosine-synthase. DR Pfam; PF00258; Flavodoxin_1; 1. DR Pfam; PF04055; Radical_SAM; 1. DR Pfam; PF08608; Wyosine_form; 1. DR SFLD; SFLDS00029; Radical_SAM; 1. DR SFLD; SFLDF00284; tRNA_wybutosine-synthesizing; 1. DR SUPFAM; SSF52218; SSF52218; 1. DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1. PE 4: Predicted; KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485}; KW Iron {ECO:0000256|ARBA:ARBA00022485}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485}; KW Lyase {ECO:0000256|ARBA:ARBA00023239}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..29 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 30..845 FT /note="Flavodoxin-like domain-containing protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5001838969" FT DOMAIN 93..287 FT /note="Flavodoxin-like" FT /evidence="ECO:0000259|PROSITE:PS50902" FT REGION 56..85 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 382..410 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 64..85 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 386..410 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 845 AA; 93761 MW; 742926487FCE4D06 CRC64; MMIAFLFQLL VSVGLPLVAL LLYNHLADSI HARGSVNVDD VNAFSQRVRA ELEQLNVPPA LPEAAPGQAA PPPAPMRSSP AVTAPPPPEA AEILIAYATQ SQNSLALAHK LFSLITAQLH TAPPSTTDDA VCPLVRVMEM REEEDSSASV AAASAAGGRV SRTNVCRVDT LLEQSQYALI IFIASTYTNG VAPPRSQAFE ALLKDSFEDH RIPRNTLARK RFAVFGLGDI AYGEERFNAF AKNLHEWCRG LGAPPFVVPP VYTTEAKTQS LFRIFSTALL KWVSRATFHR DGTVTVKKKS EMGTTGPAAA SATGMLSHKA GGITAAPAGE TCGSEGASCA CQQSTQQQQQ QRQPCGNSTG PDGDDNCGCC KTDSIANCVA ASKRDDDDEA DDDDEEEEVN GENDGMDDVE DLVWDGTEDT DFDINKDPSE LPELLYPKLR QNLEKQGYRL VGTHSGVKLC RWTKSMLRGR GGCYKHTFYN INSSQCMEMT PSLACANKCV FCWRHHTNPV SRHFRWKQDP PELLIAQGMA GHYQMIKQMR GVPGVTPERL ATAMQIRHCA LSLVGEPIMY PQINGFCELL HQHHISSFMV TNAQFPEQLR DLKPVVQLYL SIDAPTPEEL KRIDRPLFED YWERCLSCVK ELAKKQQRTV FRLTLVNQYN TENVKAYADL VEMGQPDFIE VKGVTYCGTS TSSTLTMKDN VPRHDEVISF CKALCTEMAS RHPHYSTLQM NTEEKGGDDG DDDEVIVIPA EERNRPYHVA CEHEHSCCVL IALDKFFFEG HWHTWIDYER FYHLVESGRT DFTSLDYAAV TPAWATYNSK EKGFDPEQTR VVRKNARPTV VTASC //