ID A0A087X199_HUMAN Unreviewed; 396 AA. AC A0A087X199; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 07-APR-2021, entry version 47. DE SubName: Full=Tripartite motif-containing protein 15 {ECO:0000313|Ensembl:ENSP00000484001}; GN Name=TRIM15 {ECO:0000313|Ensembl:ENSP00000484001}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484001, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000484001, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000484001} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL669914; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671855; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671859; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844220; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL845450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR388382; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR788282; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Antibodypedia; 26243; 173 antibodies. DR Ensembl; ENST00000548653; ENSP00000447232; ENSG00000233599. DR Ensembl; ENST00000548732; ENSP00000449583; ENSG00000227147. DR Ensembl; ENST00000550694; ENSP00000450011; ENSG00000235960. DR Ensembl; ENST00000550969; ENSP00000447725; ENSG00000137384. DR Ensembl; ENST00000552062; ENSP00000448307; ENSG00000235259. DR Ensembl; ENST00000619857; ENSP00000484001; ENSG00000204610. DR UCSC; uc063mqi.1; human. DR HGNC; HGNC:16284; TRIM15. DR OpenTargets; ENSG00000204610; -. DR VEuPathDB; HostDB:ENSG00000204610.12; -. DR GeneTree; ENSGT00940000162589; -. DR ChiTaRS; TRIM15; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204610; Expressed in duodenum and 100 other tissues. DR ExpressionAtlas; A0A087X199; baseline and differential. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR Gene3D; 2.60.120.920; -; 1. DR InterPro; IPR001870; B30.2/SPRY. DR InterPro; IPR043136; B30.2/SPRY_sf. DR InterPro; IPR003879; Butyrophylin_SPRY. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR006574; PRY. DR InterPro; IPR003877; SPRY_dom. DR InterPro; IPR000315; Znf_B-box. DR Pfam; PF13765; PRY; 1. DR Pfam; PF00622; SPRY; 1. DR Pfam; PF00643; zf-B_box; 1. DR PRINTS; PR01407; BUTYPHLNCDUF. DR SMART; SM00336; BBOX; 1. DR SMART; SM00589; PRY; 1. DR SMART; SM00449; SPRY; 1. DR SUPFAM; SSF49899; SSF49899; 1. DR PROSITE; PS50188; B302_SPRY; 1. DR PROSITE; PS50119; ZF_BBOX; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00024}; KW Proteomics identification {ECO:0007829|EPD:A0A087X199, KW ECO:0007829|PeptideAtlas:A0A087X199, ECO:0007829|ProteomicsDB:A0A087X199}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00024}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024}. FT DOMAIN 9..50 FT /note="B box-type" FT /evidence="ECO:0000259|PROSITE:PS50119" FT DOMAIN 207..396 FT /note="B30.2/SPRY" FT /evidence="ECO:0000259|PROSITE:PS50188" FT COILED 58..78 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 90..117 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 137..157 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 396 AA; 44767 MW; 6B2B85235520BDB4 CRC64; MAPVPLGPLG ETYCEEHGEK IYFFCENDAE FLCVFCREGP THQAHTVGFL DEAIQPYRDR LRSRLEALST ERDEIEDVKC QEDQKLQVLL TQIESKKHQV ETAFERLQQE LEQQRCLLLA RLRELEQQIW KERDEYITKV SEEVTRLGAQ VKELEEKCQQ PASELLQDVR GTIVTCEMKT FVSPEAISPD LVKKIRDFHR KILTLPEMMR MFSENLAHHL EIDSGVITLD PQTASRSLVL SEDRKSVRYT RQKKSLPDSP LRFDGLPAVL GFPGFSSGRH RWQVDLQLGD GGGCTVGVAG EGVRRKGEMG LSAEDGVWAV IISHQQCWAS TSPGTDLPLS EIPRGVRVAL DYEAGQVTLH NAQTQEPIFT FTASFSGKVF PFFAVWKKGS CLTLKG //