ID A0A087X199_HUMAN Unreviewed; 396 AA. AC A0A087X199; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 02-NOV-2016, entry version 17. DE SubName: Full=Tripartite motif-containing protein 15 {ECO:0000313|Ensembl:ENSP00000484001}; GN Name=TRIM15 {ECO:0000313|Ensembl:ENSP00000484001}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484001, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000484001, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000484001} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000447232} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Contains B30.2/SPRY domain. CC {ECO:0000256|SAAS:SAAS00512372}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSP00000484001}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL669914; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671855; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671859; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844220; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL845450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX927221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR388382; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR788282; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087X199; -. DR STRING; 9606.ENSP00000365884; -. DR PeptideAtlas; A0A087X199; -. DR Ensembl; ENST00000548653; ENSP00000447232; ENSG00000233599. DR Ensembl; ENST00000548732; ENSP00000449583; ENSG00000227147. DR Ensembl; ENST00000550694; ENSP00000450011; ENSG00000235960. DR Ensembl; ENST00000550969; ENSP00000447725; ENSG00000137384. DR Ensembl; ENST00000552062; ENSP00000448307; ENSG00000235259. DR Ensembl; ENST00000619857; ENSP00000484001; ENSG00000204610. DR UCSC; uc063mqi.1; human. DR HGNC; HGNC:16284; TRIM15. DR OpenTargets; ENSG00000137384; -. DR OpenTargets; ENSG00000204610; -. DR OpenTargets; ENSG00000227147; -. DR OpenTargets; ENSG00000233599; -. DR OpenTargets; ENSG00000235259; -. DR OpenTargets; ENSG00000235960; -. DR eggNOG; KOG2177; Eukaryota. DR eggNOG; ENOG4111G04; LUCA. DR GeneTree; ENSGT00760000118893; -. DR Proteomes; UP000005640; Chromosome 6. DR ExpressionAtlas; A0A087X199; baseline and differential. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR Gene3D; 4.10.45.10; -; 1. DR InterPro; IPR001870; B30.2/SPRY. DR InterPro; IPR003879; Butyrophylin. DR InterPro; IPR013320; ConA-like_dom. DR InterPro; IPR006574; PRY. DR InterPro; IPR003877; SPRY_dom. DR InterPro; IPR000315; Znf_B-box. DR Pfam; PF13765; PRY; 1. DR Pfam; PF00622; SPRY; 1. DR Pfam; PF00643; zf-B_box; 1. DR PRINTS; PR01407; BUTYPHLNCDUF. DR SMART; SM00336; BBOX; 1. DR SMART; SM00589; PRY; 1. DR SMART; SM00449; SPRY; 1. DR SUPFAM; SSF49899; SSF49899; 1. DR PROSITE; PS50188; B302_SPRY; 1. DR PROSITE; PS50119; ZF_BBOX; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:A0A087X199, KW ECO:0000213|MaxQB:A0A087X199, ECO:0000213|PeptideAtlas:A0A087X199}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 9 50 B box-type. {ECO:0000259|PROSITE: FT PS50119}. FT DOMAIN 207 396 B30.2/SPRY. {ECO:0000259|PROSITE: FT PS50188}. FT COILED 90 117 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 396 AA; 44767 MW; 6B2B85235520BDB4 CRC64; MAPVPLGPLG ETYCEEHGEK IYFFCENDAE FLCVFCREGP THQAHTVGFL DEAIQPYRDR LRSRLEALST ERDEIEDVKC QEDQKLQVLL TQIESKKHQV ETAFERLQQE LEQQRCLLLA RLRELEQQIW KERDEYITKV SEEVTRLGAQ VKELEEKCQQ PASELLQDVR GTIVTCEMKT FVSPEAISPD LVKKIRDFHR KILTLPEMMR MFSENLAHHL EIDSGVITLD PQTASRSLVL SEDRKSVRYT RQKKSLPDSP LRFDGLPAVL GFPGFSSGRH RWQVDLQLGD GGGCTVGVAG EGVRRKGEMG LSAEDGVWAV IISHQQCWAS TSPGTDLPLS EIPRGVRVAL DYEAGQVTLH NAQTQEPIFT FTASFSGKVF PFFAVWKKGS CLTLKG //