ID A0A087WYP9_HUMAN Unreviewed; 316 AA. AC A0A087WYP9; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 24-JAN-2024, entry version 65. DE SubName: Full=Dystrobrevin binding protein 1 {ECO:0000313|EMBL:ALQ34260.1, ECO:0000313|Ensembl:ENSP00000481997.1}; GN Name=DTNBP1 {ECO:0000313|EMBL:ALQ34260.1, GN ECO:0000313|Ensembl:ENSP00000481997.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481997.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000481997.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0007829|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [3] {ECO:0007829|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [4] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0007829|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] {ECO:0000313|EMBL:ALQ34260.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26871637; DOI=10.1016/j.cell.2016.01.029; RA Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., RA Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., RA Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., RA Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D., RA Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., RA Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., RA Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.; RT "Widespread Expansion of Protein Interaction Capabilities by Alternative RT Splicing."; RL Cell 164:805-817(2016). RN [7] {ECO:0000313|Ensembl:ENSP00000481997.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic CC vesicle membrane {ECO:0000256|ARBA:ARBA00037838}; Peripheral membrane CC protein {ECO:0000256|ARBA:ARBA00037838}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00037838}. Endoplasmic reticulum CC {ECO:0000256|ARBA:ARBA00004240}. Melanosome membrane CC {ECO:0000256|ARBA:ARBA00037798}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00037798}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00037798}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. Postsynaptic density CC {ECO:0000256|ARBA:ARBA00034105}. CC -!- SIMILARITY: Belongs to the dysbindin family. CC {ECO:0000256|ARBA:ARBA00008686}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL021978; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL022343; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KU178802; ALQ34260.1; -; mRNA. DR RefSeq; NP_001258598.1; NM_001271669.1. DR MassIVE; A0A087WYP9; -. DR Antibodypedia; 25035; 485 antibodies from 35 providers. DR DNASU; 84062; -. DR Ensembl; ENST00000622898.4; ENSP00000481997.1; ENSG00000047579.20. DR GeneID; 84062; -. DR UCSC; uc031smw.2; human. DR CTD; 84062; -. DR HGNC; HGNC:17328; DTNBP1. DR VEuPathDB; HostDB:ENSG00000047579; -. DR GeneTree; ENSGT00940000156479; -. DR OrthoDB; 5396587at2759; -. DR BioGRID-ORCS; 84062; 11 hits in 1155 CRISPR screens. DR ChiTaRS; DTNBP1; human. DR GenomeRNAi; 84062; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000047579; Expressed in tendon of biceps brachii and 180 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA. DR GO; GO:0030496; C:midbody; IDA:HPA. DR InterPro; IPR007531; Dysbindin. DR PANTHER; PTHR16294:SF5; DYSBINDIN; 1. DR PANTHER; PTHR16294; DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN; 1. DR Pfam; PF04440; Dysbindin; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|EPD:A0A087WYP9, KW ECO:0007829|MaxQB:A0A087WYP9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REGION 251..316 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 59..144 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 251..275 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 316 AA; 35566 MW; B0FAF459E3698862 CRC64; MLETLRERLL SVQQDFTSGY EDTWAALHRR AKDCASAGEL VDSEVVMLSA HWEKKKTSLV ELQEQLQQLP ALIADLESMT ANLTHLEASF EEVENNLLHL EDLCGQCELE RCKHMQSQQL ENYKKNKRKE LETFKAELDA EHAQKVLEME HTQQMKLKER QKFFEEAFQQ DMEQYLSTGY LQIAERREPI GSMSSMEVNV DMLEQMDLMD ISDQEALDVF LNSGGEENTV LSPALGPESS TCQNEITLQV PNPSELRAKP PSSSSTCTDS ATRDISEGGE SPVVQSDEEE VQVDTALATS HTDREATPDG GEDSDS //