ID A0A087WXP2_HUMAN Unreviewed; 188 AA. AC A0A087WXP2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 23-MAY-2018, entry version 29. DE SubName: Full=Nuclear factor 1 B-type {ECO:0000313|Ensembl:ENSP00000481181}; GN Name=NFIB {ECO:0000313|Ensembl:ENSP00000481181}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481181, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000481181, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000481181} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE- CC ProRule:PRU00436, ECO:0000256|SAAS:SAAS00573677}. CC -!- SIMILARITY: Belongs to the CTF/NF-I family. {ECO:0000256|PROSITE- CC ProRule:PRU00436}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL136366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL137017; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL441963; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL449443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WXP2; -. DR PeptideAtlas; A0A087WXP2; -. DR Ensembl; ENST00000622520; ENSP00000481181; ENSG00000147862. DR UCSC; uc064seg.1; human. DR EuPathDB; HostDB:ENSG00000147862.14; -. DR HGNC; HGNC:7785; NFIB. DR OpenTargets; ENSG00000147862; -. DR eggNOG; KOG3663; Eukaryota. DR eggNOG; ENOG410Y16G; LUCA. DR GeneTree; ENSGT00390000009905; -. DR ChiTaRS; NFIB; human. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000147862; -. DR ExpressionAtlas; A0A087WXP2; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule. DR InterPro; IPR000647; CTF/NFI. DR InterPro; IPR020604; CTF/NFI_DNA-bd-dom. DR InterPro; IPR019739; CTF/NFI_DNA-bd_CS. DR InterPro; IPR019548; CTF/NFI_DNA-bd_N. DR InterPro; IPR003619; MAD_homology1_Dwarfin-type. DR PANTHER; PTHR11492; PTHR11492; 1. DR Pfam; PF03165; MH1; 1. DR Pfam; PF10524; NfI_DNAbd_pre-N; 1. DR SMART; SM00523; DWA; 1. DR PROSITE; PS00349; CTF_NFI_1; 1. DR PROSITE; PS51080; CTF_NFI_2; 1. PE 1: Evidence at protein level; KW Activator {ECO:0000256|PROSITE-ProRule:PRU00436}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW DNA replication {ECO:0000256|PROSITE-ProRule:PRU00436}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00436}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00436, KW ECO:0000256|SAAS:SAAS00094706}; KW Proteomics identification {ECO:0000213|EPD:A0A087WXP2, KW ECO:0000213|MaxQB:A0A087WXP2, ECO:0000213|PeptideAtlas:A0A087WXP2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transcription {ECO:0000256|PROSITE-ProRule:PRU00436, KW ECO:0000256|SAAS:SAAS00094735}; KW Transcription regulation {ECO:0000256|PROSITE-ProRule:PRU00436, KW ECO:0000256|SAAS:SAAS00464859}. FT DOMAIN 2 188 CTF/NF-I. {ECO:0000259|PROSITE:PS51080}. FT DNA_BIND 2 188 CTF/NF-I. {ECO:0000256|PROSITE-ProRule: FT PRU00436}. SQ SEQUENCE 188 AA; 22308 MW; C703698597C13336 CRC64; MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL AYYVQEQR //