ID A0A087WT21_HUMAN Unreviewed; 1442 AA. AC A0A087WT21; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 22-FEB-2023, entry version 59. DE SubName: Full=CECR2 histone acetyl-lysine reader {ECO:0000313|Ensembl:ENSP00000477529.1}; GN Name=CECR2 {ECO:0000313|Ensembl:ENSP00000477529.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477529.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000477529.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [2] {ECO:0007829|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000477529.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2022) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC007666; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FO681548; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A087WT21; -. DR PeptideAtlas; A0A087WT21; -. DR Antibodypedia; 283; 67 antibodies from 22 providers. DR Ensembl; ENST00000612582.1; ENSP00000477529.1; ENSG00000099954.19. DR UCSC; uc062bgl.1; human. DR HGNC; HGNC:1840; CECR2. DR VEuPathDB; HostDB:ENSG00000099954; -. DR GeneTree; ENSGT00940000160360; -. DR HOGENOM; CLU_006327_0_0_1; -. DR ChiTaRS; CECR2; human. DR Proteomes; UP000005640; Chromosome 22. DR Bgee; ENSG00000099954; Expressed in tibialis anterior and 146 other tissues. DR ExpressionAtlas; A0A087WT21; baseline and differential. DR GO; GO:0090537; C:CERF complex; IEA:InterPro. DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro. DR CDD; cd05509; Bromo_gcn5_like; 1. DR Gene3D; 1.20.920.10; Bromodomain-like; 1. DR InterPro; IPR001487; Bromodomain. DR InterPro; IPR036427; Bromodomain-like_sf. DR InterPro; IPR018359; Bromodomain_CS. DR InterPro; IPR029614; CECR2. DR PANTHER; PTHR47092; CAT EYE SYNDROME CRITICAL REGION PROTEIN 2; 1. DR PANTHER; PTHR47092:SF1; CAT EYE SYNDROME CRITICAL REGION PROTEIN 2; 1. DR Pfam; PF00439; Bromodomain; 1. DR PRINTS; PR00503; BROMODOMAIN. DR SMART; SM00297; BROMO; 1. DR SUPFAM; SSF47370; Bromodomain; 1. DR PROSITE; PS00633; BROMODOMAIN_1; 1. DR PROSITE; PS50014; BROMODOMAIN_2; 1. PE 1: Evidence at protein level; KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE- KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A087WT21, KW ECO:0007829|ProteomicsDB:A0A087WT21}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 409..479 FT /note="Bromo" FT /evidence="ECO:0000259|PROSITE:PS50014" FT REGION 148..219 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 514..662 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 754..783 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 877..1011 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1123..1217 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1245..1278 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1400..1442 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 304..356 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 152..172 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 198..219 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 561..581 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 878..895 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 958..994 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1181..1195 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1197..1211 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1253..1278 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1406..1426 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1442 AA; 159682 MW; 2FD9F3C11417F411 CRC64; MPFKIQWFFK AVADGLSLEK ELEAALHRDD VEFISDLIAC LLQGCYQRRD ITPQTFHSYL EDIINYRWEL EEGKPNPLRE ASFQDLPLRT RVEILHRLCD YRLDADDVFD LLKGLDADSL RVEPLGEDNS GALYWYFYGT RMYKEDPVQG KSNGELSLSR ESEGQKNVSS IPGKTGKRRG RPPKRKKLQE EILLSEKQEE NSLASEPQTR HGSQGPGQGT WWLLCQTEEE WRQVTESFRE RTSLRERQLY KLLSEDFLPE ICNMIAQKGK RPQRTKAELH PRWMSDHLSI KPVKQEETPV LTRIEKQKRK EEEEERQILL AVQKKEQEQM LKEERKRELE EKVKAVEDRA KRRKLREERA WLLAQGKELP PELSHLDPNS PMREEKKTKD LFELDDDFTA MYKVLDVVKA HKDSWPFLEP VDESYAPNYY QIIKAPMDIS SMEKKLNGGL YCTKEEFVND MKTMFRNCRK YNGESSEYTK MSDNLERCFH RAMMKHFPGE DGDTDEEFWI REDEKREKRR SRAGRSGGSH VWTRSRDPEG SSRKQQPMEN GGKSLPPTRR APSSGDDQSS SSTQPPREVG TSNGRGFSHP LHCGGTPSQA PFLNQMRPAV PGTFGPLRGS DPATLYGSSG VPEPHPGEPV QQRQPFTMQP PVGINSLRGP RLGTPEEKQM CGGLTHLSNM GPHPGSLQLG QISGPSQDGS MYAPAQFQPG FIPPRHGGAP ARPPDFPESS EIPPSHMYRS YKYLNRVHSA VWNGNHGATN QGPLGPDEKP HLGPGPSHQP RTLGHVMDSR VMRPPVPPNQ WTEQSGFLPH GVPSSGYMRP PCKSAGHRLQ PPPVPAPSSL FGAPAQALRG VQGGDSMMDS PEMIAMQQLS SRVCPPGVPY HPHQPAHPRL PGPFPQVAHP MSVTVSAPKP ALGNPGRAPE NSEAQEPEND QAEPLPGLEE KPPGVGTSEG VYLTQLPHPT PPLQTDCTRQ SSPQERETVG PELKSSSSES ADNCKAMKGK NPWPSDSSYP GPAAQGCVRD LSTVADRGAL SENGVIGEAS PCGSEGKGLG SSGSEKLLCP RGRTLQETMP CTGQNAATPP STDPGLTGGT VSQFPPLYMP GLEYPNSAAH YHISPGLQGV GPVMGGKSPA SHPQHFPPRG FQSNHPHSGG FPRYRPPQGM RYSYHPPPQP SYHHYQRTPY YACPQSFSDW QRPLHPQGSP SGPPASQPPP PRSLFSDKNA MASLQGCETL NAALTSPTRM DAVAAKVPND GQNPGPEEEK LDESMERPES PKEFLDLDNH NAATKRQSSL SASEYLYGTP PPLSSGMGFG SSAFPPHSVM LQTGPPYTPQ RPASHFQPRA YSSPVAALPP HHPGATQPNG LSQEGPIYRC QEEGLGHFQA VMMEQIGTRS GIRGPFQEMY RPSGMQMHPV QSQASFPKTP TAATSQEEVP PHKPPTLPLD QS //