ID A0A087WT21_HUMAN Unreviewed; 1442 AA. AC A0A087WT21; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-APR-2018, entry version 34. DE SubName: Full=Cat eye syndrome critical region protein 2 {ECO:0000313|Ensembl:ENSP00000477529}; GN Name=CECR2 {ECO:0000313|Ensembl:ENSP00000477529}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477529, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000477529, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., RA Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., RA Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J., RA Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., RA Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., RA Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., RA Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., RA Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., RA Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., RA Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., RA Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., RA Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., RA Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., RA Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., RA Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., RA Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., RA Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., RA Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., RA Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., RA Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., RA Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., RA Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., RA Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., RA Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., RA Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., RA Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., RA Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., RA Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., RA Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., RA Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., RA Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., RA Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., RA O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., RA Khan A.S., Lane L., Tilahun Y., Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [2] {ECO:0000213|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., RA Blagoev B.; RT "System-wide temporal characterization of the proteome and RT phosphoproteome of human embryonic stem cell differentiation."; RL Sci. Signal. 4:rs3-RS3(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000477529} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC007666; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FO681548; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WT21; -. DR EPD; A0A087WT21; -. DR PeptideAtlas; A0A087WT21; -. DR Ensembl; ENST00000612582; ENSP00000477529; ENSG00000099954. DR UCSC; uc062bgl.1; human. DR EuPathDB; HostDB:ENSG00000099954.18; -. DR HGNC; HGNC:1840; CECR2. DR OpenTargets; ENSG00000099954; -. DR eggNOG; KOG1472; Eukaryota. DR eggNOG; COG5076; LUCA. DR GeneTree; ENSGT00760000119099; -. DR ChiTaRS; CECR2; human. DR Proteomes; UP000005640; Chromosome 22. DR Bgee; ENSG00000099954; -. DR ExpressionAtlas; A0A087WT21; baseline and differential. DR GO; GO:0090537; C:CERF complex; IEA:InterPro. DR GO; GO:0043044; P:ATP-dependent chromatin remodeling; IEA:InterPro. DR GO; GO:0021915; P:neural tube development; IEA:InterPro. DR Gene3D; 1.20.920.10; -; 1. DR InterPro; IPR001487; Bromodomain. DR InterPro; IPR036427; Bromodomain-like_sf. DR InterPro; IPR018359; Bromodomain_CS. DR InterPro; IPR029614; CECR2. DR PANTHER; PTHR22880:SF123; PTHR22880:SF123; 1. DR Pfam; PF00439; Bromodomain; 1. DR PRINTS; PR00503; BROMODOMAIN. DR SMART; SM00297; BROMO; 1. DR SUPFAM; SSF47370; SSF47370; 1. DR PROSITE; PS00633; BROMODOMAIN_1; 1. DR PROSITE; PS50014; BROMODOMAIN_2; 1. PE 1: Evidence at protein level; KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035, KW ECO:0000256|SAAS:SAAS00979529}; Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WT21}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 409 479 Bromo. {ECO:0000259|PROSITE:PS50014}. FT COILED 304 356 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1442 AA; 159682 MW; 2FD9F3C11417F411 CRC64; MPFKIQWFFK AVADGLSLEK ELEAALHRDD VEFISDLIAC LLQGCYQRRD ITPQTFHSYL EDIINYRWEL EEGKPNPLRE ASFQDLPLRT RVEILHRLCD YRLDADDVFD LLKGLDADSL RVEPLGEDNS GALYWYFYGT RMYKEDPVQG KSNGELSLSR ESEGQKNVSS IPGKTGKRRG RPPKRKKLQE EILLSEKQEE NSLASEPQTR HGSQGPGQGT WWLLCQTEEE WRQVTESFRE RTSLRERQLY KLLSEDFLPE ICNMIAQKGK RPQRTKAELH PRWMSDHLSI KPVKQEETPV LTRIEKQKRK EEEEERQILL AVQKKEQEQM LKEERKRELE EKVKAVEDRA KRRKLREERA WLLAQGKELP PELSHLDPNS PMREEKKTKD LFELDDDFTA MYKVLDVVKA HKDSWPFLEP VDESYAPNYY QIIKAPMDIS SMEKKLNGGL YCTKEEFVND MKTMFRNCRK YNGESSEYTK MSDNLERCFH RAMMKHFPGE DGDTDEEFWI REDEKREKRR SRAGRSGGSH VWTRSRDPEG SSRKQQPMEN GGKSLPPTRR APSSGDDQSS SSTQPPREVG TSNGRGFSHP LHCGGTPSQA PFLNQMRPAV PGTFGPLRGS DPATLYGSSG VPEPHPGEPV QQRQPFTMQP PVGINSLRGP RLGTPEEKQM CGGLTHLSNM GPHPGSLQLG QISGPSQDGS MYAPAQFQPG FIPPRHGGAP ARPPDFPESS EIPPSHMYRS YKYLNRVHSA VWNGNHGATN QGPLGPDEKP HLGPGPSHQP RTLGHVMDSR VMRPPVPPNQ WTEQSGFLPH GVPSSGYMRP PCKSAGHRLQ PPPVPAPSSL FGAPAQALRG VQGGDSMMDS PEMIAMQQLS SRVCPPGVPY HPHQPAHPRL PGPFPQVAHP MSVTVSAPKP ALGNPGRAPE NSEAQEPEND QAEPLPGLEE KPPGVGTSEG VYLTQLPHPT PPLQTDCTRQ SSPQERETVG PELKSSSSES ADNCKAMKGK NPWPSDSSYP GPAAQGCVRD LSTVADRGAL SENGVIGEAS PCGSEGKGLG SSGSEKLLCP RGRTLQETMP CTGQNAATPP STDPGLTGGT VSQFPPLYMP GLEYPNSAAH YHISPGLQGV GPVMGGKSPA SHPQHFPPRG FQSNHPHSGG FPRYRPPQGM RYSYHPPPQP SYHHYQRTPY YACPQSFSDW QRPLHPQGSP SGPPASQPPP PRSLFSDKNA MASLQGCETL NAALTSPTRM DAVAAKVPND GQNPGPEEEK LDESMERPES PKEFLDLDNH NAATKRQSSL SASEYLYGTP PPLSSGMGFG SSAFPPHSVM LQTGPPYTPQ RPASHFQPRA YSSPVAALPP HHPGATQPNG LSQEGPIYRC QEEGLGHFQA VMMEQIGTRS GIRGPFQEMY RPSGMQMHPV QSQASFPKTP TAATSQEEVP PHKPPTLPLD QS //