ID A0A087WRG6_MOUSE Unreviewed; 118 AA. AC A0A087WRG6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 27-MAY-2015, entry version 5. DE RecName: Full=Eyes absent homolog {ECO:0000256|RuleBase:RU362036}; DE EC=3.1.3.48 {ECO:0000256|RuleBase:RU362036}; DE Flags: Fragment; GN Name=Eya1 {ECO:0000313|Ensembl:ENSMUSP00000140619, GN ECO:0000313|MGI:MGI:109344}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000140619} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619}; RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. {ECO:0000256|RuleBase:RU362036}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|RuleBase:RU362036}; CC Note=Binds 1 Mg(2+) ion per subunit. CC {ECO:0000256|RuleBase:RU362036}; CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. EYA CC family. {ECO:0000256|RuleBase:RU362036}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000140619}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC119875; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC156988; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMUST00000189526; ENSMUSP00000140619; ENSMUSG00000025932. DR MGI; MGI:109344; Eya1. DR GeneTree; ENSGT00390000008860; -. DR Proteomes; UP000000589; Chromosome 1. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IDA:MGI. DR GO; GO:0003723; F:RNA binding; IDA:MGI. DR GO; GO:0048856; P:anatomical structure development; IGI:MGI. DR GO; GO:0035909; P:aorta morphogenesis; IMP:MGI. DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IGI:MGI. DR GO; GO:0045165; P:cell fate commitment; IMP:MGI. DR GO; GO:0034613; P:cellular protein localization; IMP:MGI. DR GO; GO:0090103; P:cochlea morphogenesis; IMP:MGI. DR GO; GO:0006302; P:double-strand break repair; ISO:MGI. DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IMP:MGI. DR GO; GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IMP:MGI. DR GO; GO:0016576; P:histone dephosphorylation; ISO:MGI. DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI. DR GO; GO:0060487; P:lung epithelial cell differentiation; IGI:MGI. DR GO; GO:0001656; P:metanephros development; IMP:MGI. DR GO; GO:0042474; P:middle ear morphogenesis; IMP:MGI. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI. DR GO; GO:0048665; P:neuron fate specification; IGI:MGI. DR GO; GO:0009887; P:organ morphogenesis; IMP:MGI. DR GO; GO:0071599; P:otic vesicle development; IGI:MGI. DR GO; GO:0071600; P:otic vesicle morphogenesis; IMP:MGI. DR GO; GO:0042473; P:outer ear morphogenesis; IMP:MGI. DR GO; GO:0003151; P:outflow tract morphogenesis; IMP:MGI. DR GO; GO:0007389; P:pattern specification process; IMP:MGI. DR GO; GO:0035335; P:peptidyl-tyrosine dephosphorylation; IDA:GOC. DR GO; GO:0060037; P:pharyngeal system development; IMP:MGI. DR GO; GO:0045739; P:positive regulation of DNA repair; ISO:MGI. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI. DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:MGI. DR GO; GO:0072513; P:positive regulation of secondary heart field cardioblast proliferation; IGI:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI. DR GO; GO:0006470; P:protein dephosphorylation; IDA:MGI. DR GO; GO:0045664; P:regulation of neuron differentiation; IMP:MGI. DR GO; GO:0010212; P:response to ionizing radiation; ISO:MGI. DR GO; GO:0048752; P:semicircular canal morphogenesis; IMP:MGI. DR GO; GO:0014706; P:striated muscle tissue development; IGI:MGI. DR GO; GO:0001657; P:ureteric bud development; IGI:MGI. DR InterPro; IPR028472; EYA_fam. DR PANTHER; PTHR10190; PTHR10190; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Hydrolase {ECO:0000256|RuleBase:RU362036}; KW Magnesium {ECO:0000256|RuleBase:RU362036}; KW Metal-binding {ECO:0000256|RuleBase:RU362036}; KW Protein phosphatase {ECO:0000256|RuleBase:RU362036}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transcription {ECO:0000256|RuleBase:RU362036}; KW Transcription regulation {ECO:0000256|RuleBase:RU362036}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000140619}. SQ SEQUENCE 118 AA; 13388 MW; 785E0E60C6942BAD CRC64; XRGSDGKSRG RGRRNNNPSP PPDSDLERVF IWDLDETIIV FHSLLTGSYA NRYGRDPPTS VSLGLRMEEM IFNLADTHLF FNDLEQNAPY LMEEPKSLGK SQRATELKCG LFNICPVF //