ID A0A087WRG6_MOUSE Unreviewed; 118 AA. AC A0A087WRG6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 26-FEB-2020, entry version 30. DE RecName: Full=Eyes absent homolog {ECO:0000256|RuleBase:RU362036}; DE EC=3.1.3.48 {ECO:0000256|RuleBase:RU362036}; DE Flags: Fragment; GN Name=Eya1 {ECO:0000313|Ensembl:ENSMUSP00000140619, GN ECO:0000313|MGI:MGI:109344}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000140619} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619}; RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620; EC=3.1.3.48; CC Evidence={ECO:0000256|RuleBase:RU362036}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|RuleBase:RU362036}; CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|RuleBase:RU362036}; CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. EYA family. CC {ECO:0000256|RuleBase:RU362036}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC119875; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC156988; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMUST00000189526; ENSMUSP00000140619; ENSMUSG00000025932. DR MGI; MGI:109344; Eya1. DR eggNOG; KOG3107; Eukaryota. DR eggNOG; ENOG410XT12; LUCA. DR GeneTree; ENSGT00950000182978; -. DR HOGENOM; CLU_2090298_0_0_1; -. DR ChiTaRS; Eya1; mouse. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000025932; Expressed in epithelium of cochlear duct and 241 other tissues. DR ExpressionAtlas; A0A087WRG6; baseline and differential. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0042471; P:ear morphogenesis; IEA:InterPro. DR Gene3D; 3.40.50.12350; -; 1. DR InterPro; IPR038102; EYA_dom_sf. DR InterPro; IPR028472; EYA_fam. DR InterPro; IPR028471; Eyes_absent_h1. DR PANTHER; PTHR10190; PTHR10190; 1. DR PANTHER; PTHR10190:SF11; PTHR10190:SF11; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|RuleBase:RU362036}; KW Magnesium {ECO:0000256|RuleBase:RU362036}; KW Metal-binding {ECO:0000256|RuleBase:RU362036}; KW Protein phosphatase {ECO:0000256|RuleBase:RU362036}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transcription {ECO:0000256|RuleBase:RU362036}; KW Transcription regulation {ECO:0000256|RuleBase:RU362036}. FT REGION 1..26 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000140619" SQ SEQUENCE 118 AA; 13388 MW; 785E0E60C6942BAD CRC64; XRGSDGKSRG RGRRNNNPSP PPDSDLERVF IWDLDETIIV FHSLLTGSYA NRYGRDPPTS VSLGLRMEEM IFNLADTHLF FNDLEQNAPY LMEEPKSLGK SQRATELKCG LFNICPVF //