ID A0A087WRG6_MOUSE Unreviewed; 118 AA. AC A0A087WRG6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 12-SEP-2018, entry version 21. DE RecName: Full=Eyes absent homolog {ECO:0000256|RuleBase:RU362036}; DE EC=3.1.3.48 {ECO:0000256|RuleBase:RU362036}; DE Flags: Fragment; GN Name=Eya1 {ECO:0000313|Ensembl:ENSMUSP00000140619, GN ECO:0000313|MGI:MGI:109344}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000140619} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619}; RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. {ECO:0000256|RuleBase:RU362036}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|RuleBase:RU362036}; CC Note=Binds 1 Mg(2+) ion per subunit. CC {ECO:0000256|RuleBase:RU362036}; CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. EYA CC family. {ECO:0000256|RuleBase:RU362036}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC119875; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC156988; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMUST00000189526; ENSMUSP00000140619; ENSMUSG00000025932. DR MGI; MGI:109344; Eya1. DR eggNOG; KOG3107; Eukaryota. DR eggNOG; ENOG410XT12; LUCA. DR GeneTree; ENSGT00390000008860; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000025932; Expressed in 242 organ(s), highest expression level in epithelium of cochlear duct. DR ExpressionAtlas; A0A087WRG6; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0003723; F:RNA binding; IEA:Ensembl. DR GO; GO:0035909; P:aorta morphogenesis; IEA:Ensembl. DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl. DR GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl. DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl. DR GO; GO:0007501; P:mesodermal cell fate specification; IEA:Ensembl. DR GO; GO:0001656; P:metanephros development; IEA:Ensembl. DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl. DR GO; GO:0048665; P:neuron fate specification; IEA:Ensembl. DR GO; GO:0071600; P:otic vesicle morphogenesis; IEA:Ensembl. DR GO; GO:0042473; P:outer ear morphogenesis; IEA:Ensembl. DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl. DR GO; GO:0007389; P:pattern specification process; IEA:Ensembl. DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl. DR GO; GO:0072513; P:positive regulation of secondary heart field cardioblast proliferation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0016925; P:protein sumoylation; IEA:Ensembl. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:Ensembl. DR GO; GO:0048752; P:semicircular canal morphogenesis; IEA:Ensembl. DR GO; GO:0014706; P:striated muscle tissue development; IEA:Ensembl. DR Gene3D; 3.40.50.12350; -; 1. DR InterPro; IPR038102; EYA_dom_sf. DR InterPro; IPR028472; EYA_fam. DR InterPro; IPR028471; Eyes_absent_h1. DR PANTHER; PTHR10190; PTHR10190; 1. DR PANTHER; PTHR10190:SF11; PTHR10190:SF11; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Hydrolase {ECO:0000256|RuleBase:RU362036}; KW Magnesium {ECO:0000256|RuleBase:RU362036}; KW Metal-binding {ECO:0000256|RuleBase:RU362036}; KW Protein phosphatase {ECO:0000256|RuleBase:RU362036}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transcription {ECO:0000256|RuleBase:RU362036}; KW Transcription regulation {ECO:0000256|RuleBase:RU362036}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000140619}. SQ SEQUENCE 118 AA; 13388 MW; 785E0E60C6942BAD CRC64; XRGSDGKSRG RGRRNNNPSP PPDSDLERVF IWDLDETIIV FHSLLTGSYA NRYGRDPPTS VSLGLRMEEM IFNLADTHLF FNDLEQNAPY LMEEPKSLGK SQRATELKCG LFNICPVF //