ID A0A087WRG6_MOUSE Unreviewed; 118 AA. AC A0A087WRG6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 15-FEB-2017, entry version 13. DE RecName: Full=Eyes absent homolog {ECO:0000256|RuleBase:RU362036}; DE EC=3.1.3.48 {ECO:0000256|RuleBase:RU362036}; DE Flags: Fragment; GN Name=Eya1 {ECO:0000313|Ensembl:ENSMUSP00000140619, GN ECO:0000313|MGI:MGI:109344}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140619, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000140619} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140619}; RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. {ECO:0000256|RuleBase:RU362036}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|RuleBase:RU362036}; CC Note=Binds 1 Mg(2+) ion per subunit. CC {ECO:0000256|RuleBase:RU362036}; CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. EYA CC family. {ECO:0000256|RuleBase:RU362036}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000140619}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC119875; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC156988; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10090.ENSMUSP00000126383; -. DR PaxDb; A0A087WRG6; -. DR Ensembl; ENSMUST00000189526; ENSMUSP00000140619; ENSMUSG00000025932. DR MGI; MGI:109344; Eya1. DR eggNOG; KOG3107; Eukaryota. DR eggNOG; ENOG410XT12; LUCA. DR GeneTree; ENSGT00390000008860; -. DR Proteomes; UP000000589; Chromosome 1. DR ExpressionAtlas; A0A087WRG6; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0043234; C:protein complex; IEA:Ensembl. DR GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0003723; F:RNA binding; IEA:Ensembl. DR GO; GO:0035909; P:aorta morphogenesis; IEA:Ensembl. DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl. DR GO; GO:0034613; P:cellular protein localization; IEA:Ensembl. DR GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl. DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl. DR GO; GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IEA:Ensembl. DR GO; GO:0060487; P:lung epithelial cell differentiation; IEA:Ensembl. DR GO; GO:0007501; P:mesodermal cell fate specification; IEA:Ensembl. DR GO; GO:0001656; P:metanephros development; IEA:Ensembl. DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl. DR GO; GO:0048665; P:neuron fate specification; IEA:Ensembl. DR GO; GO:0071600; P:otic vesicle morphogenesis; IEA:Ensembl. DR GO; GO:0042473; P:outer ear morphogenesis; IEA:Ensembl. DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl. DR GO; GO:0007389; P:pattern specification process; IEA:Ensembl. DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl. DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl. DR GO; GO:0072513; P:positive regulation of secondary heart field cardioblast proliferation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl. DR GO; GO:0016925; P:protein sumoylation; IEA:Ensembl. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:Ensembl. DR GO; GO:0048752; P:semicircular canal morphogenesis; IEA:Ensembl. DR GO; GO:0014706; P:striated muscle tissue development; IEA:Ensembl. DR InterPro; IPR028472; EYA_fam. DR InterPro; IPR028471; Eyes_absent_h1. DR PANTHER; PTHR10190; PTHR10190; 1. DR PANTHER; PTHR10190:SF18; PTHR10190:SF18; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Hydrolase {ECO:0000256|RuleBase:RU362036}; KW Magnesium {ECO:0000256|RuleBase:RU362036}; KW Metal-binding {ECO:0000256|RuleBase:RU362036}; KW Protein phosphatase {ECO:0000256|RuleBase:RU362036}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transcription {ECO:0000256|RuleBase:RU362036}; KW Transcription regulation {ECO:0000256|RuleBase:RU362036}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000140619}. SQ SEQUENCE 118 AA; 13388 MW; 785E0E60C6942BAD CRC64; XRGSDGKSRG RGRRNNNPSP PPDSDLERVF IWDLDETIIV FHSLLTGSYA NRYGRDPPTS VSLGLRMEEM IFNLADTHLF FNDLEQNAPY LMEEPKSLGK SQRATELKCG LFNICPVF //