ID A0A087WQ20_MOUSE Unreviewed; 128 AA. AC A0A087WQ20; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 27-NOV-2024, entry version 46. DE SubName: Full=Transformed mouse 3T3 cell double minute 4 {ECO:0000313|Ensembl:ENSMUSP00000140006.2}; GN Name=Mdm4 {ECO:0000313|Ensembl:ENSMUSP00000140006.2, GN ECO:0000313|MGI:MGI:107934}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000140006.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140006.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140006.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000140006.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140006.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000140006.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140006.2}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A087WQ20; -. DR SMR; A0A087WQ20; -. DR Antibodypedia; 20673; 767 antibodies from 37 providers. DR Ensembl; ENSMUST00000191212.7; ENSMUSP00000140006.2; ENSMUSG00000054387.14. DR AGR; MGI:107934; -. DR MGI; MGI:107934; Mdm4. DR VEuPathDB; HostDB:ENSMUSG00000054387; -. DR GeneTree; ENSGT00530000063539; -. DR ChiTaRS; Mdm4; mouse. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000054387; Expressed in secondary oocyte and 246 other cell types or tissues. DR ExpressionAtlas; A0A087WQ20; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro. DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro. DR CDD; cd17673; MDM4; 1. DR FunFam; 1.10.245.10:FF:000002; E3 ubiquitin-protein ligase Mdm2; 1. DR Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1. DR InterPro; IPR051652; MDM2_MDM4_MUL1. DR InterPro; IPR016495; p53_neg-reg_MDM_2/4. DR InterPro; IPR036885; SWIB_MDM2_dom_sf. DR InterPro; IPR003121; SWIB_MDM2_domain. DR PANTHER; PTHR12183; MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1; 1. DR PANTHER; PTHR12183:SF37; PROTEIN MDM4; 1. DR Pfam; PF02201; SWIB; 1. DR PIRSF; PIRSF006748; p53_MDM_2/4; 1. DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1. DR PROSITE; PS51925; SWIB_MDM2; 1. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Proteomics identification {ECO:0007829|ProteomicsDB:A0A087WQ20}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}. FT DOMAIN 23..109 FT /note="DM2" FT /evidence="ECO:0000259|PROSITE:PS51925" SQ SEQUENCE 128 AA; 14271 MW; 5D7CF148D782818D CRC64; MTSHSTSAQC SASDSACRIS SEQISQQVRP KLQLLKILHA AGAQGEVFTM KEVMHYLGQY IMVKQLYDQQ EQHMVYCGGD LLGDLLGCQS FSVKDPSPLY DMLRKNLVTS ASINTARCNR ILQSQKKN //